DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment M1BP and AZF1

DIOPT Version :9

Sequence 1:	NP_649825.1	Gene:	M1BP / 41042	FlyBaseID:	FBgn0037621	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_014756.3	Gene:	AZF1 / 854280	SGDID:	S000005639	Length:	914	Species:	Saccharomyces cerevisiae

Alignment Length:	339	Identity:	76/339 - (22%)
Similarity:	125/339 - (36%)	Gaps:	69/339 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 EQRQGISAFYRAAVMGEDIVQTVKTPDDDEVYATYQEIVLEEPKEEIDDTKVE------YDNTYY 148
            |..:|::.....:.|..:|::..| .||..||...:....:.|..:.:.|..|      :.....
Yeast   449 EGSEGLNKHIDESGMQPNIIKKRK-KDDSTVYVKNEMPRTDPPMSKDNSTSAEGAAMANFSGKEP 512

  Fly   149 EVAEGHAGEDDAASLIEEADYDSIM----AEDEEQQQTLELDEDTELIVGDVNDAYVYDSDDEVA 209
            .:.:..:..|||.:||.....|.:|    |..:...:.:...:|.:|:.....|.
Yeast   513 PIPDISSVSDDATNLIGATKVDQLMLIIQARKKGFTEKVNTTQDGDLLFNQTMDI---------- 567

  Fly   210 VLDNVLDDEYEHENIVVKKCSLPPKPKVRSDDARRRGTGGVYICEQCGNHIKGRMAFELHCRRHR 274
                                 ||||.::.....:.:||                       :..|
Yeast   568 ---------------------LPPKSELVGGVEKPKGT-----------------------QNTR 588

  Fly   275 GDKQFGCELCQSRFCTTSELKRHMRKHTGERPFACKYCGRCFTDYTTRVKHERTHTNERPYVCGT 339
            ..|:..|..|...|...:.|:.|:|.|.|.:||.|.|||:.||.......|||.||.|:||.|..
Yeast   589 AVKKHECPYCHRLFSQATHLEVHVRSHIGYKPFVCDYCGKRFTQGGNLRTHERLHTGEKPYSCDI 653

  Fly   340 CGKAFTTGYILKNHMLIHSGERAYRCEL--CDKSFMLPTHLSTHFRSGVHKRHLEKAEMKQVLEQ 402
            |.|.|:....|..|::.|...:.:.|:|  |:|:|....::..| ::..||..|.....| :.|.
Yeast   654 CDKKFSRKGNLAAHLVTHQKLKPFVCKLENCNKTFTQLGNMKAH-QNRFHKETLNALTAK-LAEM 716

  Fly   403 EQKRELKEEEEDSL 416
            .....:..||...|
Yeast   717 NPSENIPLEERQLL 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
M1BP	NP_649825.1	zf-AD	13..84	CDD:214871
		C2H2 Zn finger	253..273	CDD:275368	0/19 (0%)
		COG5048	276..>331	CDD:227381	21/54 (39%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
		zf-H2C2_2	293..317	CDD:290200	11/23 (48%)
		C2H2 Zn finger	309..329	CDD:275368	9/19 (47%)
		zf-H2C2_2	324..346	CDD:290200	12/21 (57%)
		C2H2 Zn finger	337..357	CDD:275368	6/19 (32%)
		zf-H2C2_2	350..372	CDD:290200	7/23 (30%)
		C2H2 Zn finger	365..383	CDD:275368	6/19 (32%)
AZF1	NP_014756.3	COG5048	342..768	CDD:227381	76/339 (22%)
		C2H2 Zn finger	595..615	CDD:275368	6/19 (32%)
		C2H2 Zn finger	623..643	CDD:275368	9/19 (47%)
		C2H2 Zn finger	651..671	CDD:275368	6/19 (32%)
		C2H2 Zn finger	679..702	CDD:275368	6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000