DRSC/TRiP Functional Genomics Resources

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Protein Alignment M1BP and ZNF527

DIOPT Version :9

Sequence 1:NP_649825.1 Gene:M1BP / 41042 FlyBaseID:FBgn0037621 Length:418 Species:Drosophila melanogaster
Sequence 2:NP_115829.1 Gene:ZNF527 / 84503 HGNCID:29385 Length:609 Species:Homo sapiens


Alignment Length:204 Identity:72/204 - (35%)
Similarity:92/204 - (45%) Gaps:38/204 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   220 EHENI-------VVKKCSLPPKPKVRSDDARRRGTG-GVYICEQCGNHIKGRMAFELHCRRHRGD 276
            ||:.|       ..|:|:...:.....:..:|..|| ..|.|.|||.....|:|..||.|.|.|:
Human   375 EHQRIHTGEKPYECKECNKAFRQSAHLNQHQRIHTGEKPYECNQCGKAFSRRIALTLHQRIHTGE 439

  Fly   277 KQFGCELCQSRF-----------------------C-----TTSELKRHMRKHTGERPFACKYCG 313
            |.|.|..|...|                       |     |.|:|.||.|.|||||||.|..||
Human   440 KPFKCSECGKTFGYRSHLNQHQRIHTGEKPYECIKCGKFFRTDSQLNRHHRIHTGERPFECSKCG 504

  Fly   314 RCFTDYTTRVKHERTHTNERPYVCGTCGKAFTTGYILKNHMLIHSGERAYRCELCDKSFMLPTHL 378
            :.|:|....:.|:|:|..|:||.|..|||||:.|..|..|..||:||:.|.|..|.|:|.....|
Human   505 KAFSDALVLIHHKRSHAGEKPYECNKCGKAFSCGSYLNQHQRIHTGEKPYECSECGKAFHQILSL 569

  Fly   379 STHFRSGVH 387
            ..|.|  :|
Human   570 RLHQR--IH 576

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
M1BPNP_649825.1 zf-AD 13..84 CDD:214871
C2H2 Zn finger 253..273 CDD:275368 9/19 (47%)
COG5048 276..>331 CDD:227381 27/82 (33%)
C2H2 Zn finger 281..301 CDD:275368 10/47 (21%)
zf-H2C2_2 293..317 CDD:290200 14/23 (61%)
C2H2 Zn finger 309..329 CDD:275368 7/19 (37%)
zf-H2C2_2 324..346 CDD:290200 12/21 (57%)
C2H2 Zn finger 337..357 CDD:275368 9/19 (47%)
zf-H2C2_2 350..372 CDD:290200 10/21 (48%)
C2H2 Zn finger 365..383 CDD:275368 6/17 (35%)
ZNF527NP_115829.1 KRAB 14..53 CDD:279668
C2H2 Zn finger 222..240 CDD:275368
C2H2 Zn finger 252..268 CDD:275368
C2H2 Zn finger 277..296 CDD:275368
C2H2 Zn finger 304..324 CDD:275368
zf-H2C2_2 317..341 CDD:290200
COG5048 <328..490 CDD:227381 31/114 (27%)
C2H2 Zn finger 332..352 CDD:275368
zf-H2C2_2 344..369 CDD:290200
C2H2 Zn finger 360..380 CDD:275368 2/4 (50%)
zf-H2C2_2 373..397 CDD:290200 5/21 (24%)
C2H2 Zn finger 388..408 CDD:275368 3/19 (16%)
zf-H2C2_2 400..425 CDD:290200 8/24 (33%)
C2H2 Zn finger 416..436 CDD:275368 9/19 (47%)
zf-H2C2_2 428..453 CDD:290200 11/24 (46%)
C2H2 Zn finger 444..464 CDD:275368 3/19 (16%)
zf-H2C2_2 456..481 CDD:290200 1/24 (4%)
C2H2 Zn finger 472..492 CDD:275368 7/19 (37%)
zf-H2C2_2 485..508 CDD:290200 14/22 (64%)
C2H2 Zn finger 500..520 CDD:275368 7/19 (37%)
zf-H2C2_2 516..537 CDD:290200 12/20 (60%)
C2H2 Zn finger 528..548 CDD:275368 9/19 (47%)
zf-H2C2_2 540..565 CDD:290200 11/24 (46%)
C2H2 Zn finger 556..576 CDD:275368 7/21 (33%)
zf-H2C2_2 568..593 CDD:290200 4/11 (36%)
C2H2 Zn finger 584..604 CDD:275368
KRAB 14..74 CDD:214630
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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