Protein Alignment M1BP and PLAG1

DIOPT Version :10

• Sequence 1: NP_649825.1
• Gene: M1BP / 41042
• FlyBaseID: FBgn0037621
• Length: 418
• Species: Drosophila melanogaster
• Sequence 2: NP_002646.2
• Gene: PLAG1 / 5324
• HGNCID: 9045
• Length: 500
• Species: Homo sapiens
• Alignment Length: 149
• Identity: 47/149 - (31%)
• Similarity: 67/149 - (44%)
• Gaps: 27/149 - (18%)

  Fly   271 RRHRGD----KQFGCELCQSRFCTTSELKRHMRKHTGERPFAC--KYCGRCFTDYTTRVKHERTH 329
            :|.||:    |.|.|:||...|.:..:||.|...||||||:.|  :.|.:.|.......:|..||
Human    22 KRKRGETKPRKNFPCQLCDKAFNSVEKLKVHSYSHTGERPYKCIQQDCTKAFVSKYKLQRHMATH 86

  Fly   330 TNERPYVCGTCGKAFTTGYILKNHMLIHS-GERAYRCELCDKSFM----LPTHLSTH-------- 381
            :.|:.:.|..|.|.|.....||||:..|. .:..::||.|.|::.    ...||:.|
Human    87 SPEKTHKCNYCEKMFHRKDHLKNHLHTHDPNKETFKCEECGKNYNTKLGFKRHLALHAATSGDLT 151

  Fly   382 -------FRS-GVHKRHLE 392
                   |.| ||...||:
Human   152 CKVCLQTFESTGVLLEHLK 170

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
M1BP	NP_649825.1	zf-AD	13..84	CDD:214871
		C2H2 Zn finger	253..273	CDD:275368	0/1 (0%)
		COG5048	276..>331	CDD:227381	21/60 (35%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		zf-H2C2_2	293..317	CDD:463886	11/25 (44%)
		C2H2 Zn finger	309..329	CDD:275368	4/21 (19%)
		zf-H2C2_2	324..346	CDD:463886	8/21 (38%)
		C2H2 Zn finger	337..357	CDD:275368	8/19 (42%)
		zf-H2C2_2	350..372	CDD:463886	9/22 (41%)
		C2H2 Zn finger	365..383	CDD:275368	7/36 (19%)
PLAG1	NP_002646.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		3/7 (43%)
		Interaction with KPNA2. /evidence=ECO:0000269|PubMed:11882654	2..84		22/61 (36%)
		Nuclear localization signal	22..25		1/2 (50%)
		C2H2 Zn finger	36..56	CDD:275368	7/19 (37%)
		Decreased nuclear import with localization in the nucleus but also in the cytoplasm	41..242		39/130 (30%)
		SFP1	<58..139	CDD:227516	24/80 (30%)
		C2H2 Zn finger	64..86	CDD:275368	4/21 (19%)
		zf-H2C2_2	79..101	CDD:463886	7/21 (33%)
		C2H2 Zn finger	94..114	CDD:275368	8/19 (42%)
		C2H2 Zn finger	123..143	CDD:275368	6/19 (32%)
		C2H2 Zn finger	152..172	CDD:275368	6/19 (32%)
		C2H2 Zn finger	187..207	CDD:275368
		C2H2 Zn finger	215..233	CDD:275368
		Activates transcription, Inhibition of nuclear import due to lack of NLS and KPNA2 interaction	243..500
		Repression domain, contains 3 sumoylation motifs and massively decrease transcription activity	243..384
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	365..388
		Massively activates transcription	385..500