DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment M1BP and ouib

DIOPT Version :9

Sequence 1:	NP_649825.1	Gene:	M1BP / 41042	FlyBaseID:	FBgn0037621	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_649822.2	Gene:	ouib / 41039	FlyBaseID:	FBgn0037618	Length:	312	Species:	Drosophila melanogaster

Alignment Length:	385	Identity:	128/385 - (33%)
Similarity:	190/385 - (49%)	Gaps:	77/385 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LKSTCRVCAKYASNKRSPKLFERSNTKMIDNIEALTGLRLENYGCLPDQICECCSMELASAVKLR 73
            |...||||.:....::|..||:..|.|.:.::..::||||.:...:|..:|.||..||.||:..|
  Fly     2 LNIVCRVCGRQKICEKSLNLFDLVNRKYLKHLHMISGLRLVDLDDVPGFMCLCCQAELRSALAFR 66

  Fly    74 ERCIAAQRELLLGLTEEQRQGISAFYRAAVMGEDIVQTVKTPDDDEVYATYQEIVLEEPKEEIDD 138
            :.||..|.:.|. :.::...|          .||      |.|:.|         ||..|....|
  Fly    67 KLCIKTQTKWLT-IEDDSSSG----------DED------TNDNSE---------LESEKCAFSD 105

  Fly   139 TKVEYDNTYYEVAEGHAGEDDAASLIEEADYDSIMAEDEEQQQTLELDEDTELIVGDVNDAYVYD 203
                            .|:.....|:||.  ..::.|:|...:||..|...:|....:::..|
  Fly   106 ----------------FGKKKEGELVEET--FQVLIEEEPMDKTLNRDAKAQLREDGIDEKCV-- 150

  Fly   204 SDDEVAVLDNVLDDEYEHENIVVKKCSLPPKPKVRSDDARRRGTGGVYICEQCGNHIKGRMAFEL 268
            ...::..:...|||:                               :||||.||.|...:..|:.
  Fly   151 PSQKIIKVSTKLDDQ-------------------------------IYICELCGTHATSKPTFQR 184

  Fly   269 HCRRHRGDKQFGCELCQSRFCTTSELKRHMRKHTGERPFACKYCGRCFTDYTTRVKHERTHTNER 333
            |.|:|||::.|||:.|.:||.:..||:.|.|.||||:||||::|.:.:..|..|:.|||||||:|
  Fly   185 HMRKHRGERPFGCKDCDARFLSAGELRAHHRVHTGEQPFACRFCEKRYVSYMGRLIHERTHTNDR 249

  Fly   334 PYVCGTCGKAFTTGYILKNHMLIHSGERAYRCELCDKSFMLPTHLSTHFRSGVHKRHLEK 393
            ||||..|||.|||.|:|||||:||:|||.:||::||:||....||.||.||.:|.::::|
  Fly   250 PYVCEECGKKFTTAYVLKNHMVIHTGERNFRCDICDRSFQRKAHLVTHTRSMMHLQNVKK 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
M1BP	NP_649825.1	zf-AD	13..84	CDD:214871	25/70 (36%)
		C2H2 Zn finger	253..273	CDD:275368	8/19 (42%)
		COG5048	276..>331	CDD:227381	26/54 (48%)
		C2H2 Zn finger	281..301	CDD:275368	8/19 (42%)
		zf-H2C2_2	293..317	CDD:290200	13/23 (57%)
		C2H2 Zn finger	309..329	CDD:275368	7/19 (37%)
		zf-H2C2_2	324..346	CDD:290200	16/21 (76%)
		C2H2 Zn finger	337..357	CDD:275368	13/19 (68%)
		zf-H2C2_2	350..372	CDD:290200	14/21 (67%)
		C2H2 Zn finger	365..383	CDD:275368	9/17 (53%)
ouib	NP_649822.2	zf-AD	5..78	CDD:214871	25/72 (35%)
		COG5048	<158..300	CDD:227381	76/172 (44%)
		C2H2 Zn finger	169..189	CDD:275368	8/19 (42%)
		C2H2 Zn finger	197..217	CDD:275368	8/19 (42%)
		zf-H2C2_2	209..234	CDD:290200	13/24 (54%)
		C2H2 Zn finger	225..245	CDD:275368	7/19 (37%)
		zf-H2C2_2	241..262	CDD:290200	16/20 (80%)
		C2H2 Zn finger	253..273	CDD:275368	13/19 (68%)
		zf-H2C2_2	266..288	CDD:290200	14/21 (67%)
		C2H2 Zn finger	281..299	CDD:275368	9/17 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447753
Domainoid	1	1.000	48	1.000	Domainoid score	I19075
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I2531
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000724
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_120097
Panther	1	1.100	-	-	P	PTHR24388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.890