DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment M1BP and ZNF850

DIOPT Version :9

Sequence 1:	NP_649825.1	Gene:	M1BP / 41042	FlyBaseID:	FBgn0037621	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_001180481.1	Gene:	ZNF850 / 342892	HGNCID:	27994	Length:	1090	Species:	Homo sapiens

Alignment Length:	136	Identity:	58/136 - (42%)
Similarity:	78/136 - (57%)	Gaps:	8/136 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 YICEQCGNHIKGRMAFELHCRRHRGDKQFGCELCQSRFCTTSELKRHMRKHTGERPFACKYCGRC 315
            |.|::||...........|.|.|.|:|.:.|:.|...|.:.|.|.:|.|.||||:|:.||.||:.
Human   421 YDCKECGKSFTAGSTLIQHQRIHTGEKPYDCKECGKSFASGSALLQHQRIHTGEKPYCCKECGKS 485

  Fly   316 FTDYTTRVKHERTHTNERPYVCGTCGKAFTTGYILKNHMLIHSGERAYRCELCDKSFMLPTHLST 380
            ||..:||.:|:|.||.|:||.|..|||:|.:|..|..|..||:||:.|.|:.|.|||.
Human   486 FTFRSTRNRHQRIHTGEKPYNCKECGKSFASGSALLQHQRIHTGEKPYHCKECGKSFT------- 543

  Fly   381 HFRSGV 386
             ||||:
Human   544 -FRSGL 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
M1BP	NP_649825.1	zf-AD	13..84	CDD:214871
		C2H2 Zn finger	253..273	CDD:275368	5/19 (26%)
		COG5048	276..>331	CDD:227381	24/54 (44%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		zf-H2C2_2	293..317	CDD:290200	12/23 (52%)
		C2H2 Zn finger	309..329	CDD:275368	10/19 (53%)
		zf-H2C2_2	324..346	CDD:290200	12/21 (57%)
		C2H2 Zn finger	337..357	CDD:275368	8/19 (42%)
		zf-H2C2_2	350..372	CDD:290200	10/21 (48%)
		C2H2 Zn finger	365..383	CDD:275368	5/17 (29%)
ZNF850	NP_001180481.1	KRAB	7..67	CDD:214630
		KRAB	7..46	CDD:279668
		C2H2 Zn finger	199..219	CDD:275368
		C2H2 Zn finger	227..244	CDD:275368
		COG5048	243..659	CDD:227381	58/136 (43%)
		C2H2 Zn finger	255..275	CDD:275368
		C2H2 Zn finger	283..303	CDD:275368
		zf-H2C2_2	296..319	CDD:290200
		C2H2 Zn finger	311..331	CDD:275368
		zf-H2C2_2	324..348	CDD:290200
		C2H2 Zn finger	339..359	CDD:275368
		zf-H2C2_2	351..375	CDD:290200
		C2H2 Zn finger	367..387	CDD:275368
		zf-H2C2_2	379..403	CDD:290200
		C2H2 Zn finger	395..415	CDD:275368
		C2H2 Zn finger	423..443	CDD:275368	5/19 (26%)
		zf-H2C2_2	436..460	CDD:290200	8/23 (35%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		zf-H2C2_2	463..487	CDD:290200	12/23 (52%)
		C2H2 Zn finger	479..499	CDD:275368	10/19 (53%)
		zf-H2C2_2	493..516	CDD:290200	12/22 (55%)
		C2H2 Zn finger	507..527	CDD:275368	8/19 (42%)
		zf-H2C2_2	519..543	CDD:290200	11/23 (48%)
		COG5048	531..947	CDD:227381	10/26 (38%)
		C2H2 Zn finger	535..555	CDD:275368	9/22 (41%)
		C2H2 Zn finger	563..583	CDD:275368
		zf-H2C2_2	575..599	CDD:290200
		C2H2 Zn finger	591..611	CDD:275368
		C2H2 Zn finger	619..639	CDD:275368
		zf-H2C2_2	632..656	CDD:290200
		C2H2 Zn finger	647..667	CDD:275368
		zf-H2C2_2	660..684	CDD:290200
		C2H2 Zn finger	675..695	CDD:275368
		zf-H2C2_2	687..711	CDD:290200
		C2H2 Zn finger	703..723	CDD:275368
		C2H2 Zn finger	732..751	CDD:275368
		C2H2 Zn finger	759..779	CDD:275368
		C2H2 Zn finger	787..807	CDD:275368
		C2H2 Zn finger	815..835	CDD:275368
		C2H2 Zn finger	843..863	CDD:275368
		zf-H2C2_2	856..879	CDD:290200
		C2H2 Zn finger	871..891	CDD:275368
		C2H2 Zn finger	899..919	CDD:275368
		zf-H2C2_2	912..936	CDD:290200
		C2H2 Zn finger	927..947	CDD:275368
		C2H2 Zn finger	955..975	CDD:275368
		zf-H2C2_2	967..992	CDD:290200
		C2H2 Zn finger	983..1003	CDD:275368
		zf-H2C2_2	995..1020	CDD:290200
		C2H2 Zn finger	1011..1031	CDD:275368
		zf-H2C2_2	1024..1046	CDD:290200
		C2H2 Zn finger	1039..1059	CDD:275368
		zf-H2C2_2	1052..1076	CDD:290200
		C2H2 Zn finger	1067..1087	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910