DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment M1BP and Zfp12

DIOPT Version :9

Sequence 1:	NP_649825.1	Gene:	M1BP / 41042	FlyBaseID:	FBgn0037621	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_001276518.1	Gene:	Zfp12 / 231866	MGIID:	99157	Length:	686	Species:	Mus musculus

Alignment Length:	379	Identity:	101/379 - (26%)
Similarity:	135/379 - (35%)	Gaps:	117/379 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LPDQICECCSMEL----------ASAVKLRER-CIAAQRELLLGLTEEQRQGISAFYRAAVMGED 107
            ||.  |..|...|          .|..|||.. |....:.|.....||...|..::..:....||
Mouse   131 LPQ--CNSCEKSLMCVSAFIRSDGSYAKLRPNVCAGCGKPLPCSKPEETHPGGESYEFSGDGDED 193

  Fly   108 IVQTVKTPDDDEVYATYQE-IVLEEPKEEIDDTKVEYDNTYYEVAEGHAGEDDAASLIEEADYDS 171
                   |..:|  ..||: ..||||.|.::..|.....|   |...|..|:..
Mouse   194 -------PLGEE--GVYQKGHFLEEPFEYVECQKSFPKGT---VFLNHLEEEPC----------- 235

  Fly   172 IMAEDEEQQQTLELDEDTELIVGDVNDAYVYDSDDEVAVLDNVLDDEYEHENIVVKKCSLPPKPK 236
                                   |.|||       |||.|..  .|...|::.:::.     ||
Mouse   236 -----------------------DWNDA-------EVAFLQT--SDLSAHQDSLMEM-----KP- 262

  Fly   237 VRSDDARRRGTGGVYICEQCGNHIKGRMAFELHCRRHRGDKQFGCELCQSRFCTTSELKRHMRKH 301
                          |.|:|||.....:..|.:|.|.|.|:|.|.|..|...||....|..|.|.|
Mouse   263 --------------YECQQCGKSFCKKSKFVIHQRTHTGEKPFKCSQCGKSFCQKGTLTVHQRTH 313

  Fly   302 TGERPFACK----------------------------YCGRCFTDYTTRVKHERTHTNERPYVCG 338
            |||:|:.|.                            |||:.|...|...:|:|||:.||||||.
Mouse   314 TGEKPYECTECGKTFYQKLHLIQHQRTHSGEKPYKCGYCGKSFCQKTHLTQHQRTHSGERPYVCH 378

  Fly   339 TCGKAFTTGYILKNHMLIHSGERAYRCELCDKSFMLPTHLSTHFRSGVHKRHLE 392
            .|||.|:....|.:|..||:|.:.|:|..|.|.|...:.|:||.|:...::..|
Mouse   379 DCGKTFSQKSALNDHQKIHTGVKLYKCSECGKCFCRKSTLTTHMRTHTGEKPYE 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
M1BP	NP_649825.1	zf-AD	13..84	CDD:214871	10/40 (25%)
		C2H2 Zn finger	253..273	CDD:275368	7/19 (37%)
		COG5048	276..>331	CDD:227381	24/82 (29%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		zf-H2C2_2	293..317	CDD:290200	12/51 (24%)
		C2H2 Zn finger	309..329	CDD:275368	8/47 (17%)
		zf-H2C2_2	324..346	CDD:290200	14/21 (67%)
		C2H2 Zn finger	337..357	CDD:275368	7/19 (37%)
		zf-H2C2_2	350..372	CDD:290200	9/21 (43%)
		C2H2 Zn finger	365..383	CDD:275368	7/17 (41%)
Zfp12	NP_001276518.1	C2H2 Zn finger	489..509	CDD:275368
		C2H2 Zn finger	517..537	CDD:275368
		C2H2 Zn finger	545..565	CDD:275368
		C2H2 Zn finger	573..593	CDD:275368
		C2H2 Zn finger	601..621	CDD:275368
		C2H2 Zn finger	629..649	CDD:275368
		C2H2 Zn finger	657..677	CDD:275368
		KRAB	8..68	CDD:214630
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..129
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..198		6/30 (20%)
		COG5048	251..677	CDD:227381	62/202 (31%)
		C2H2 Zn finger	265..285	CDD:275368	7/19 (37%)
		C2H2 Zn finger	293..313	CDD:275368	7/19 (37%)
		C2H2 Zn finger	321..341	CDD:275368	1/19 (5%)
		C2H2 Zn finger	349..369	CDD:275368	7/19 (37%)
		C2H2 Zn finger	377..397	CDD:275368	7/19 (37%)
		C2H2 Zn finger	405..425	CDD:275368	8/19 (42%)
		C2H2 Zn finger	433..453	CDD:275368	101/379 (27%)
		C2H2 Zn finger	461..481	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000