DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment M1BP and ZNF721

DIOPT Version :9

Sequence 1:	NP_649825.1	Gene:	M1BP / 41042	FlyBaseID:	FBgn0037621	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_597731.2	Gene:	ZNF721 / 170960	HGNCID:	29425	Length:	923	Species:	Homo sapiens

Alignment Length:	446	Identity:	112/446 - (25%)
Similarity:	165/446 - (36%)	Gaps:	114/446 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 CRVCAK-------YASNKR---SPKLFERSNT-KMIDNIEALTGLRLENYGCLPDQICECCSMEL 66
            |:.|.|       :|.:||   ..|.||.... |...:...||..|..:.|..| ..||.|....
Human   475 CKQCGKVITSSSSFAKHKRIHTGEKPFECLECGKAFTSSTTLTKHRRIHTGEKP-YTCEVCGKAF 538

  Fly    67 -ASAVKLRERCIAAQRELLLG---LTEEQ-----RQGISAF-YRAAVMGEDIVQTVKTPDDDEVY 121
             .||:      :...|.:..|   .|.|:     ||..:.: :|....||   :..|..:..:.:
Human   539 RQSAI------LYVHRRIHTGEKPYTCEECGKTFRQSANLYVHRRIHTGE---KPYKCEECGKAF 594

  Fly   122 ATYQEIVLEEPKEEIDDTKVEYDNTYYEVAEGHAGEDDAASLIEEADYDSIMAEDEEQQQTL--- 183
            ..|.::                 |.:.::   |.||  .....||...|.:...|..||:.:
Human   595 GRYTDL-----------------NQHKKI---HTGE--KLYKCEECGKDFVWYTDLNQQKKIYTG 637

  Fly   184 -----------------ELDEDTELIVGDVNDAYVYDSDDEVAVLDNVLDDEYEHENIVV----K 227
                             :|::.|:::.|:  .:|..:...:.......|:   :|:.|..    .
Human   638 EKPYKCEECGKAFAPSTDLNQHTKILTGE--QSYKCEECGKAFGWSIALN---QHKKIHTGEKPY 697

  Fly   228 KCS-------------------LPPKPKVRSDDARRRG------------TGG-VYICEQCGNHI 260
            ||.                   ...||....|..|..|            ||. :|.|::||...
Human   698 KCEECGKAFSRSRNLTTHRRVHTREKPYKCEDRGRSFGWSTNLNEYKKIHTGDKLYKCKECGKVF 762

  Fly   261 KGRMAFELHCRRHRGDKQFGCELCQSRFCTTSELKRHMRKHTGERPFACKYCGRCFTDYTTRVKH 325
            |.......|.:.|.|.|.:.|:.|.....::|...:|.|.||||:||.|..||:.||..||..||
Human   763 KQSSHLNRHEKIHTGKKPYKCKECGKVITSSSSFAKHKRIHTGEKPFKCLECGKAFTSSTTLTKH 827

  Fly   326 ERTHTNERPYVCGTCGKAFTTGYILKNHMLIHSGERAYRCELCDKSFMLPTHLSTH 381
            .|.||.|:||.|..|||||....||..|..||:||:.|.|..|.|:|....:|..|
Human   828 RRIHTGEKPYTCEECGKAFRQSAILYVHRRIHTGEKPYTCGECGKTFRQSANLYAH 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
M1BP	NP_649825.1	zf-AD	13..84	CDD:214871	21/82 (26%)
		C2H2 Zn finger	253..273	CDD:275368	5/19 (26%)
		COG5048	276..>331	CDD:227381	23/54 (43%)
		C2H2 Zn finger	281..301	CDD:275368	5/19 (26%)
		zf-H2C2_2	293..317	CDD:290200	11/23 (48%)
		C2H2 Zn finger	309..329	CDD:275368	10/19 (53%)
		zf-H2C2_2	324..346	CDD:290200	14/21 (67%)
		C2H2 Zn finger	337..357	CDD:275368	9/19 (47%)
		zf-H2C2_2	350..372	CDD:290200	10/21 (48%)
		C2H2 Zn finger	365..383	CDD:275368	6/17 (35%)
ZNF721	NP_597731.2	C2H2 Zn finger	83..103	CDD:275368
		COG5048	93..492	CDD:227381	4/16 (25%)
		C2H2 Zn finger	111..131	CDD:275368
		C2H2 Zn finger	139..159	CDD:275368
		zf-H2C2_2	151..176	CDD:290200
		C2H2 Zn finger	167..187	CDD:275368
		C2H2 Zn finger	223..243	CDD:275368
		zf-H2C2_2	235..257	CDD:290200
		C2H2 Zn finger	251..271	CDD:275368
		C2H2 Zn finger	279..299	CDD:275368
		zf-H2C2_2	292..316	CDD:290200
		C2H2 Zn finger	307..327	CDD:275368
		zf-H2C2_2	319..344	CDD:290200
		C2H2 Zn finger	335..355	CDD:275368
		zf-H2C2_2	347..372	CDD:290200
		C2H2 Zn finger	363..383	CDD:275368
		zf-H2C2_2	375..400	CDD:290200
		C2H2 Zn finger	391..411	CDD:275368
		COG5048	442..885	CDD:227381	112/446 (25%)
		C2H2 Zn finger	447..467	CDD:275368
		C2H2 Zn finger	475..495	CDD:275368	6/19 (32%)
		zf-H2C2_2	487..512	CDD:290200	7/24 (29%)
		C2H2 Zn finger	503..523	CDD:275368	4/19 (21%)
		zf-H2C2_2	516..540	CDD:290200	8/24 (33%)
		C2H2 Zn finger	531..551	CDD:275368	6/25 (24%)
		zf-H2C2_2	544..568	CDD:290200	4/23 (17%)
		C2H2 Zn finger	559..579	CDD:275368	4/19 (21%)
		zf-H2C2_2	571..596	CDD:290200	4/27 (15%)
		C2H2 Zn finger	587..607	CDD:275368	2/39 (5%)
		C2H2 Zn finger	615..634	CDD:275368	6/18 (33%)
		C2H2 Zn finger	643..663	CDD:275368	2/19 (11%)
		C2H2 Zn finger	671..691	CDD:275368	2/22 (9%)
		zf-H2C2_2	683..708	CDD:290200	5/27 (19%)
		C2H2 Zn finger	699..719	CDD:275368	1/19 (5%)
		C2H2 Zn finger	755..775	CDD:275368	5/19 (26%)
		zf-H2C2_2	767..789	CDD:290200	6/21 (29%)
		C2H2 Zn finger	783..803	CDD:275368	5/19 (26%)
		zf-H2C2_2	795..820	CDD:290200	12/24 (50%)
		C2H2 Zn finger	811..831	CDD:275368	10/19 (53%)
		zf-H2C2_2	824..848	CDD:290200	14/23 (61%)
		C2H2 Zn finger	839..859	CDD:275368	9/19 (47%)
		zf-H2C2_2	852..876	CDD:290200	11/23 (48%)
		C2H2 Zn finger	867..887	CDD:275368	6/17 (35%)
		C2H2 Zn finger	895..915	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000