DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment M1BP and ZNF784

DIOPT Version :9

Sequence 1:	NP_649825.1	Gene:	M1BP / 41042	FlyBaseID:	FBgn0037621	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_976308.1	Gene:	ZNF784 / 147808	HGNCID:	33111	Length:	323	Species:	Homo sapiens

Alignment Length:	174	Identity:	54/174 - (31%)
Similarity:	74/174 - (42%)	Gaps:	39/174 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 CEQCGNHIKGRMAFELHCRRHRGDKQFGCELCQSRFCTTSELKRHMRKHTGE------------- 304
            |..||:...|..:...|...|.|::.:.|.||...|...:.|.||..:|..|
Human   103 CHVCGHSCPGPASLRAHYSLHTGERPYRCALCPRAFKALAPLLRHQHRHGVEPGTSRRPPDTAAV 167

  Fly   305 --------------------------RPFACKYCGRCFTDYTTRVKHERTHTNERPYVCGTCGKA 343
                                      :||||::|.:.|...:....|||.||.||||.||.|||.
Human   168 AEQRPGVAPERAEVVMAAAAAGAAVGKPFACRFCAKPFRRSSDMRDHERVHTGERPYHCGICGKG 232

  Fly   344 FTTGYILKNHMLIHSGERAYRCELCDKSFMLPTHLSTHFRSGVH 387
            ||...:|..|..||:|||.:||.|||::|...::...|.|:..|
Human   233 FTQSSVLSGHARIHTGERPFRCTLCDRTFNNSSNFRKHQRTHFH 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
M1BP	NP_649825.1	zf-AD	13..84	CDD:214871
		C2H2 Zn finger	253..273	CDD:275368	5/19 (26%)
		COG5048	276..>331	CDD:227381	19/93 (20%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		zf-H2C2_2	293..317	CDD:290200	10/62 (16%)
		C2H2 Zn finger	309..329	CDD:275368	6/19 (32%)
		zf-H2C2_2	324..346	CDD:290200	15/21 (71%)
		C2H2 Zn finger	337..357	CDD:275368	9/19 (47%)
		zf-H2C2_2	350..372	CDD:290200	12/21 (57%)
		C2H2 Zn finger	365..383	CDD:275368	6/17 (35%)
ZNF784	NP_976308.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		C2H2 Zn finger	67..87	CDD:275368
		C2H2 Zn finger	103..123	CDD:275368	5/19 (26%)
		C2H2 Zn finger	131..151	CDD:275368	7/19 (37%)
		COG5048	<194..276	CDD:227381	37/81 (46%)
		C2H2 Zn finger	198..218	CDD:275368	6/19 (32%)
		C2H2 Zn finger	226..246	CDD:275368	9/19 (47%)
		C2H2 Zn finger	254..274	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	269..323		3/8 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	118	1.000	Inparanoid score	I4797
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050