DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and Zkscan8

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_631880.2	Gene:	Zkscan8 / 93681	MGIID:	1913815	Length:	588	Species:	Mus musculus

Alignment Length:	325	Identity:	88/325 - (27%)
Similarity:	126/325 - (38%)	Gaps:	84/325 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CRTCGKRTNAERSLNIFEKRNQTTLEHIKLLTGAVLKNCSTLPNRLCASCQTCLQQAISFRERCL 70
            |..|||..          .:|...:.|.::.||.....|:     :|.       :|.|:|.
Mouse   334 CDECGKSF----------AQNSGLVRHWRIHTGEKPYQCT-----VCG-------KAFSYRS--- 373

  Fly    71 EVQRELLHSQDDEDFLR--ICQESPKSVLEQEELELDLAEISIEVERLDDLNEGPIQSSGFKVED 133
                .||..||..:.::  .|:|..|:..:...|.|.        :|: ...|.|.|.
Mouse   374 ----ALLSHQDIHNKVKRYHCKECGKAFSQNTGLILH--------QRI-HTGEKPYQC------- 418

  Fly   134 ILNESKINEDEPNNEDDIDYSEMDYLIYESDTEVDAKQELKSDSENPKKRRNRRNPRDSNRTFFC 198
                         |:....:|:...||..        |.:.|                ..|.:.|
Mouse   419 -------------NQCGKAFSQSAGLILH--------QRIHS----------------GERPYEC 446

  Fly   199 EECGNHIKDRISFILHCKRHRGVKEFGCEFCEDRFCTPAELKRHIRKHTGEKPFKCRHCSRSFSD 263
            .|||.........|.|.:.|.|.|.:.|:.|...|...:.|..|.|.||||||:||..|.|:||.
Mouse   447 NECGKAFSHSSHLIGHQRIHTGEKPYECDECGKTFRRSSHLIGHQRSHTGEKPYKCNECGRAFSQ 511

  Fly   264 YSTRLKHERTHTNERPFVCKECNNAFTTSYILKNHMLVHTGEKAFRCDLCDKLFSRYTHLTTHYR 328
            .|..::|:|.||.|||:.||||..||..:..|..|:.:|||||.::|..|.|.|.:.:.|..|.|
Mouse   512 KSGLIEHQRIHTGERPYKCKECGKAFNGNTGLIQHLRIHTGEKPYQCSECRKAFIQRSSLIRHQR 576

Fly 329 328
Mouse 577 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871	13/70 (19%)
		C2H2 Zn finger	198..218	CDD:275368	6/19 (32%)
		COG5048	222..>276	CDD:227381	23/53 (43%)
		C2H2 Zn finger	226..246	CDD:275368	6/19 (32%)
		zf-H2C2_2	238..262	CDD:290200	13/23 (57%)
		C2H2 Zn finger	254..274	CDD:275368	8/19 (42%)
		zf-H2C2_2	269..291	CDD:290200	13/21 (62%)
		C2H2 Zn finger	282..302	CDD:275368	8/19 (42%)
		zf-H2C2_2	295..319	CDD:290200	11/23 (48%)
		C2H2 Zn finger	310..328	CDD:275368	6/17 (35%)
Zkscan8	NP_631880.2	SCAN	48..158	CDD:128708
		KRAB_A-box	233..268	CDD:143639
		COG5048	<322..574	CDD:227381	86/321 (27%)
		C2H2 Zn finger	334..354	CDD:275368	6/29 (21%)
		C2H2 Zn finger	363..382	CDD:275368	8/37 (22%)
		C2H2 Zn finger	390..410	CDD:275368	6/28 (21%)
		C2H2 Zn finger	418..438	CDD:275368	5/47 (11%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..494	CDD:275368	6/19 (32%)
		C2H2 Zn finger	502..522	CDD:275368	8/19 (42%)
		C2H2 Zn finger	530..550	CDD:275368	8/19 (42%)
		C2H2 Zn finger	558..578	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000