DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and ZNF616

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_848618.2	Gene:	ZNF616 / 90317	HGNCID:	28062	Length:	781	Species:	Homo sapiens

Alignment Length:	397	Identity:	98/397 - (24%)
Similarity:	153/397 - (38%)	Gaps:	79/397 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CRTCGKRTNAERSLNIFEKRNQTTLEHIKLLTGAVLKNCSTLPNRLCASCQTCLQQAI------- 63
            |..|||.         |.:|....| |..:.||.....|:........|....:.|.|
Human   299 CNLCGKS---------FSQRVHLRL-HQTVHTGERPFKCNECGKTFKRSSNLTVHQVIHAGKKPY 353

  Fly    64 -------SFRERCLEVQRELLHSQDDEDFLRICQESPKSVLEQEELELDLAEISIEVERLDDLNE 121
                   :||.|...|....:||.:.:   ..|.|..|...::..|.:.....:  ||:....||
Human   354 KCDVCGKAFRHRSNLVCHRRIHSGEKQ---YKCNECGKVFSKRSSLAVHRRIHT--VEKPCKCNE 413

  Fly   122 -GPIQSSGFKVEDILNESKINEDEPN---NEDDIDYSEMDYL--------------------IYE 162
             |.:.|   |...:....:|:..:..   |:....||:..:|                    ::.
Human   414 CGKVFS---KRSSLAVHQRIHTGQKTYKCNKCGKVYSKHSHLAVHWRIHTGEKAYKCNECGKVFS 475

  Fly   163 SDTEVDAKQELKSDSENPKK---------RRNR----RNPRDSNRTFFCEECGNHIKDRISFILH 214
            ..:.:.|.|.:.: .|.|.|         :.:|    |......:.:.|:|||....||.:|..|
Human   476 IHSRLAAHQRIHT-GEKPYKCNECGKVFSQHSRLAVHRRIHTGEKPYKCKECGKVFSDRSAFARH 539

  Fly   215 CKRHRGVKEFGCEFCEDRFCTPAELKRHIRKHTGEKPFKCRHCSRSFSDYSTRLKHERTHTNERP 279
            .:.|.|.|.:.|:.|...|...:.|..|.|.|:||||:||..|.:.:|.||..:.|.|.||.|:|
Human   540 RRIHTGEKPYKCKECGKVFSQCSRLTVHRRIHSGEKPYKCNECGKVYSQYSHLVGHRRVHTGEKP 604

  Fly   280 FVCKECNNAFTTSYILKNHMLVHTGEKAFRCDLCDKLFSRYTHLTTH---------YRSNAHRRN 335
            :.|.||..||.....|..|..:|||||.::|:.|...||:..||..|         |:.|...:.
Human   605 YKCHECGKAFNQGSTLNRHQRIHTGEKPYKCNQCGNSFSQRVHLRLHQTVHTGDRPYKCNECGKT 669

  Fly   336 MQKADTI 342
            .:::..:
Human   670 FKRSSNL 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871	18/84 (21%)
		C2H2 Zn finger	198..218	CDD:275368	8/19 (42%)
		COG5048	222..>276	CDD:227381	21/53 (40%)
		C2H2 Zn finger	226..246	CDD:275368	6/19 (32%)
		zf-H2C2_2	238..262	CDD:290200	11/23 (48%)
		C2H2 Zn finger	254..274	CDD:275368	7/19 (37%)
		zf-H2C2_2	269..291	CDD:290200	11/21 (52%)
		C2H2 Zn finger	282..302	CDD:275368	7/19 (37%)
		zf-H2C2_2	295..319	CDD:290200	10/23 (43%)
		C2H2 Zn finger	310..328	CDD:275368	7/26 (27%)
ZNF616	NP_848618.2	KRAB	7..61	CDD:214630
		KRAB	7..46	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	105..129
		C2H2 Zn finger	187..207	CDD:275368
		zf-H2C2_2	199..224	CDD:290200
		C2H2 Zn finger	243..263	CDD:275368
		COG5048	266..707	CDD:227381	98/397 (25%)
		C2H2 Zn finger	271..291	CDD:275368
		zf-H2C2_2	283..308	CDD:290200	5/17 (29%)
		C2H2 Zn finger	299..319	CDD:275368	8/29 (28%)
		zf-H2C2_2	311..336	CDD:290200	5/25 (20%)
		C2H2 Zn finger	327..347	CDD:275368	3/19 (16%)
		C2H2 Zn finger	355..375	CDD:275368	4/19 (21%)
		C2H2 Zn finger	383..403	CDD:275368	4/19 (21%)
		C2H2 Zn finger	411..431	CDD:275368	5/22 (23%)
		C2H2 Zn finger	439..459	CDD:275368	4/19 (21%)
		C2H2 Zn finger	467..487	CDD:275368	2/19 (11%)
		zf-H2C2_2	480..504	CDD:290200	5/24 (21%)
		C2H2 Zn finger	495..515	CDD:275368	2/19 (11%)
		zf-H2C2_2	508..531	CDD:290200	5/22 (23%)
		C2H2 Zn finger	523..543	CDD:275368	8/19 (42%)
		zf-H2C2_2	538..560	CDD:290200	7/21 (33%)
		C2H2 Zn finger	551..571	CDD:275368	6/19 (32%)
		C2H2 Zn finger	579..599	CDD:275368	7/19 (37%)
		zf-H2C2_2	591..616	CDD:290200	11/24 (46%)
		C2H2 Zn finger	607..627	CDD:275368	7/19 (37%)
		zf-H2C2_2	620..644	CDD:290200	10/23 (43%)
		C2H2 Zn finger	635..655	CDD:275368	7/19 (37%)
		zf-H2C2_2	647..672	CDD:290200	5/24 (21%)
		C2H2 Zn finger	663..683	CDD:275368	1/14 (7%)
		C2H2 Zn finger	691..711	CDD:275368
		zf-H2C2_2	703..728	CDD:290200
		C2H2 Zn finger	719..739	CDD:275368
		zf-H2C2_2	731..754	CDD:290200
		C2H2 Zn finger	747..767	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910