DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and ZNF628

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_149104.3	Gene:	ZNF628 / 89887	HGNCID:	28054	Length:	1059	Species:	Homo sapiens

Alignment Length:	151	Identity:	53/151 - (35%)
Similarity:	79/151 - (52%)	Gaps:	2/151 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 RRNPRD--SNRTFFCEECGNHIKDRISFILHCKRHRGVKEFGCEFCEDRFCTPAELKRHIRKHTG 248
            |.:.||  ..|.:.|.|||...|......:|.:.|.|::.|.|..|...|...:..:.|:|.|:|
Human   470 RYHLRDHTGERPYQCGECGKAFKRSSLLAIHQRVHTGLRAFTCGQCGLTFKWSSHYQYHLRLHSG 534

  Fly   249 EKPFKCRHCSRSFSDYSTRLKHERTHTNERPFVCKECNNAFTTSYILKNHMLVHTGEKAFRCDLC 313
            |:|:.|..|.::|.:.|...:|...||.|||..|..|..:|..:..|:.|..|||||:.|||.||
Human   535 ERPYACGECGKAFRNTSCLRRHRHVHTGERPHACGVCGKSFAQTSNLRQHQRVHTGERPFRCPLC 599

  Fly   314 DKLFSRYTHLTTHYRSNAHRR 334
            .|.|:..::|..|.|:::..|
Human   600 PKTFTHSSNLLLHQRTHSAER 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871
		C2H2 Zn finger	198..218	CDD:275368	6/19 (32%)
		COG5048	222..>276	CDD:227381	16/53 (30%)
		C2H2 Zn finger	226..246	CDD:275368	5/19 (26%)
		zf-H2C2_2	238..262	CDD:290200	8/23 (35%)
		C2H2 Zn finger	254..274	CDD:275368	5/19 (26%)
		zf-H2C2_2	269..291	CDD:290200	9/21 (43%)
		C2H2 Zn finger	282..302	CDD:275368	5/19 (26%)
		zf-H2C2_2	295..319	CDD:290200	14/23 (61%)
		C2H2 Zn finger	310..328	CDD:275368	7/17 (41%)
ZNF628	NP_149104.3	C2H2 Zn finger	38..58	CDD:275368
		COG5048	<43..213	CDD:227381
		C2H2 Zn finger	66..86	CDD:275368
		C2H2 Zn finger	94..114	CDD:275368
		C2H2 Zn finger	122..142	CDD:275368
		C2H2 Zn finger	150..170	CDD:275368
		C2H2 Zn finger	178..198	CDD:275368
		zf-C2H2	204..226	CDD:306579
		C2H2 Zn finger	206..226	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..247
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..280
		C2H2 Zn finger	297..314	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..351
		C2H2 Zn finger	361..378	CDD:275370
		C2H2 Zn finger	388..408	CDD:275368
		COG5048	<453..642	CDD:227381	53/151 (35%)
		C2H2 Zn finger	456..476	CDD:275368	2/5 (40%)
		C2H2 Zn finger	484..504	CDD:275368	6/19 (32%)
		C2H2 Zn finger	512..532	CDD:275368	5/19 (26%)
		C2H2 Zn finger	540..560	CDD:275368	5/19 (26%)
		C2H2 Zn finger	568..588	CDD:275368	5/19 (26%)
		C2H2 Zn finger	596..616	CDD:275368	8/19 (42%)
		C2H2 Zn finger	624..644	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	644..674
		4 X approximate tandem repeats. /evidence=ECO:0000250\|UniProtKB:Q8CJ78	818..864
		Interaction with TAF4B. /evidence=ECO:0000250\|UniProtKB:Q8CJ78	943..1059
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910