DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and ZNF559

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_001189335.1	Gene:	ZNF559 / 84527	HGNCID:	28197	Length:	602	Species:	Homo sapiens

Alignment Length:	418	Identity:	104/418 - (24%)
Similarity:	166/418 - (39%)	Gaps:	84/418 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KVCRTCGKRTNAERSLNIFEKRNQTTL---------------EHIKLLTGAVLKNCSTLPNRL-- 51
            |.|. |.:...|.|..:||....:|.:               :|:.|:.....:|...:..:.
Human   181 KTCE-CNQCEKAFRKPSIFTLHKKTDIGEELPNCNQCETAFSQHLHLVCKKTSQNLHLVCKKTHT 244

  Fly    52 ------CASCQTCLQQAISFRERCLEV---QRELLH------------------SQDDEDFLRIC 89
                  |:.|:..|..:...|| |:.:   :|...|                  :||.|.|.. |
Human   245 QEKPYKCSDCEKGLPSSSHLRE-CVRIYGGERPYTHKEYVETFSHSTALFVHMQTQDGEKFYE-C 307

  Fly    90 QESPKSVLEQEELELDLAE----ISIEVERL--------DDLNEGPIQSSGFKVEDILNE----- 137
            :...|...|...|...|..    :.||.::.        |......:::.|  ...:.||
Human   308 KACGKPFTESSYLTQHLRTHSRVLPIEHKKFGKAFAFSPDLAKHIRLRTRG--KHYVCNECGKEF 370

  Fly   138 ---SKIN-------EDEPN--NEDDIDYSEMDYLIYESDTEVDAK----QELKSDSENPKKRRNR 186
               ||:|       .::|.  |:....:::...||....|....|    :|......|.......
Human   371 TCFSKLNIHIRVHTGEKPYECNKCGKAFTDSSGLIKHRRTHTGEKPYECKECGKAFANSSHLTVH 435

  Fly   187 RNPRDSNRTFFCEECGNHIKDRISFILHCKRHRGVKEFGCEFCEDRFCTPAELKRHIRKHTGEKP 251
            .......:.:.|:|||....:..||..|.:.|.|||.:.|:.|...|...:.|.||:|.|:.|:|
Human   436 MRTHTGEKPYQCKECGKAFINSSSFKSHMQTHPGVKPYDCQQCGKAFIRSSFLIRHLRSHSAERP 500

  Fly   252 FKCRHCSRSFSDYSTRL-KHERTHTNERPFVCKECNNAFTTSYILKNHMLVHTGEKAFRCDLCDK 315
            |:|..|.::|. ||:.| :|:|.||.|||:.|::|..||:.|..|..||..||||:.|.|..|.|
Human   501 FECEECGKAFR-YSSHLSQHKRIHTGERPYKCQKCGQAFSISSGLTVHMRTHTGERPFECQECGK 564

  Fly   316 LFSRYTHLTTHYRSNAHRRNMQKADTIF 343
            .|:|.|:|..|.||::..:..::....|
Human   565 AFTRSTYLIRHLRSHSVEKPYKECGQTF 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871	17/97 (18%)
		C2H2 Zn finger	198..218	CDD:275368	7/19 (37%)
		COG5048	222..>276	CDD:227381	21/54 (39%)
		C2H2 Zn finger	226..246	CDD:275368	7/19 (37%)
		zf-H2C2_2	238..262	CDD:290200	10/23 (43%)
		C2H2 Zn finger	254..274	CDD:275368	8/20 (40%)
		zf-H2C2_2	269..291	CDD:290200	11/21 (52%)
		C2H2 Zn finger	282..302	CDD:275368	8/19 (42%)
		zf-H2C2_2	295..319	CDD:290200	12/23 (52%)
		C2H2 Zn finger	310..328	CDD:275368	8/17 (47%)
ZNF559	NP_001189335.1	KRAB	78..>118	CDD:214630
		KRAB	78..117	CDD:279668
		C2H2 Zn finger	158..177	CDD:275368
		C2H2 Zn finger	185..240	CDD:275368	9/54 (17%)
		COG5048	212..601	CDD:227381	96/386 (25%)
		C2H2 Zn finger	213..243	CDD:275368	3/29 (10%)
		C2H2 Zn finger	251..299	CDD:275368	8/48 (17%)
		C2H2 Zn finger	307..327	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		zf-H2C2_2	376..399	CDD:290200	3/22 (14%)
		C2H2 Zn finger	391..411	CDD:275368	3/19 (16%)
		zf-H2C2_2	404..428	CDD:290200	5/23 (22%)
		C2H2 Zn finger	419..439	CDD:275368	2/19 (11%)
		zf-H2C2_2	431..454	CDD:290200	4/22 (18%)
		zf-C2H2	445..467	CDD:278523	7/21 (33%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		zf-H2C2_2	488..512	CDD:290200	11/24 (46%)
		C2H2 Zn finger	503..523	CDD:275368	8/20 (40%)
		zf-H2C2_2	515..539	CDD:290200	11/23 (48%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		zf-H2C2_2	544..568	CDD:290200	12/23 (52%)
		C2H2 Zn finger	559..579	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910