DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and ZNF527

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_115829.1	Gene:	ZNF527 / 84503	HGNCID:	29385	Length:	609	Species:	Homo sapiens

Alignment Length:	408	Identity:	99/408 - (24%)
Similarity:	147/408 - (36%)	Gaps:	144/408 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 ISFRERCLE---VQRELL--HSQDDEDFLRICQESPKSVLEQEELELDLAEISIEVERLDDLNEG 122
            ||..|:..|   |:|::.  |..|.|.:..|.:.|||..::::|:..::.     :|||  .:.|
Human    63 ISLLEQGKEPWMVERKMSQGHCADWESWCEIEELSPKWFIDEDEISQEMV-----MERL--ASHG 120

  Fly   123 PIQSSGFK-------------------------VEDILNESKINE-------------------- 142
             ::.|.|:                         |::|....:.||
Human   121 -LECSSFREAWKYKGEFELHQGNAERHFMQVTAVKEISTGKRDNEFSNSGRSIPLKSVFLTQQKV 184

  Fly   143 ------------DE--PNNEDDIDY----SEMDYLIYESDTEVDAKQELKSD-----SENPKKRR 184
                        |:  |.|...|:|    :|.:.||.....|.:....|..|     .|.|.:..
Human   185 PTIQQVHKFDIYDKLFPQNSVIIEYKRLHAEKESLIGNECEEFNQSTYLSKDIGIPPGEKPYESH 249

  Fly   185 N-----------------------------------------RRNPRDSNRTFFCEECGNHIKDR 208
            :                                         .:......:.:.|.:||......
Human   250 DFSKLLSFHSLFTQHQTTHFGKLPHGYDECGDAFSCYSFFTQPQRIHSGEKPYACNDCGKAFSHD 314

  Fly   209 ISFILHCKRHRGVKEFGCEFCEDRFCTPAELKRHIRKHTGEKPFKCRHCSRSFSDYSTRLKHERT 273
            .....|.:.|.|.|.:.|:.|...|...|.|.:|.|.|||||||.|..|.::||.|:..::|:|.
Human   315 FFLSEHQRTHIGEKPYECKECNKAFRQSAHLAQHQRIHTGEKPFACNECGKAFSRYAFLVEHQRI 379

  Fly   274 HTNERPFVCKECNNAFTTSYILKNHMLVHTGEKAFRCDLCDKLFSRYTHLTTH------------ 326
            ||.|:|:.|||||.||..|..|..|..:|||||.:.|:.|.|.|||...||.|
Human   380 HTGEKPYECKECNKAFRQSAHLNQHQRIHTGEKPYECNQCGKAFSRRIALTLHQRIHTGEKPFKC 444

  Fly   327 --------YRS--NAHRR 334
                    |||  |.|:|
Human   445 SECGKTFGYRSHLNQHQR 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871	6/16 (38%)
		C2H2 Zn finger	198..218	CDD:275368	4/19 (21%)
		COG5048	222..>276	CDD:227381	23/53 (43%)
		C2H2 Zn finger	226..246	CDD:275368	7/19 (37%)
		zf-H2C2_2	238..262	CDD:290200	12/23 (52%)
		C2H2 Zn finger	254..274	CDD:275368	7/19 (37%)
		zf-H2C2_2	269..291	CDD:290200	13/21 (62%)
		C2H2 Zn finger	282..302	CDD:275368	10/19 (53%)
		zf-H2C2_2	295..319	CDD:290200	11/23 (48%)
		C2H2 Zn finger	310..328	CDD:275368	9/37 (24%)
ZNF527	NP_115829.1	KRAB	14..53	CDD:279668
		C2H2 Zn finger	222..240	CDD:275368	3/17 (18%)
		C2H2 Zn finger	252..268	CDD:275368	0/15 (0%)
		C2H2 Zn finger	277..296	CDD:275368	0/18 (0%)
		C2H2 Zn finger	304..324	CDD:275368	4/19 (21%)
		zf-H2C2_2	317..341	CDD:290200	7/23 (30%)
		COG5048	<328..490	CDD:227381	56/135 (41%)
		C2H2 Zn finger	332..352	CDD:275368	7/19 (37%)
		zf-H2C2_2	344..369	CDD:290200	13/24 (54%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		zf-H2C2_2	373..397	CDD:290200	13/23 (57%)
		C2H2 Zn finger	388..408	CDD:275368	10/19 (53%)
		zf-H2C2_2	400..425	CDD:290200	11/24 (46%)
		C2H2 Zn finger	416..436	CDD:275368	9/19 (47%)
		zf-H2C2_2	428..453	CDD:290200	3/24 (13%)
		C2H2 Zn finger	444..464	CDD:275368	6/19 (32%)
		zf-H2C2_2	456..481	CDD:290200	3/7 (43%)
		C2H2 Zn finger	472..492	CDD:275368
		zf-H2C2_2	485..508	CDD:290200
		C2H2 Zn finger	500..520	CDD:275368
		zf-H2C2_2	516..537	CDD:290200
		C2H2 Zn finger	528..548	CDD:275368
		zf-H2C2_2	540..565	CDD:290200
		C2H2 Zn finger	556..576	CDD:275368
		zf-H2C2_2	568..593	CDD:290200
		C2H2 Zn finger	584..604	CDD:275368
		KRAB	14..74	CDD:214630	4/10 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000