DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and ZNF224

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_001308574.1	Gene:	ZNF224 / 7767	HGNCID:	13017	Length:	707	Species:	Homo sapiens

Alignment Length:	413	Identity:	100/413 - (24%)
Similarity:	156/413 - (37%)	Gaps:	95/413 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CRTCGKRTNAERSLNIFEK------------------RNQTTLEHIKLLTGAVLKNCSTLPNRLC 52
            |..|||..:...:||:..|                  .:....||.::.||.....|.......|
Human   234 CVECGKGFSRRSALNVHHKLHTGEKPYNCEECGKAFIHDSQLQEHQRIHTGEKPFKCDICGKSFC 298

  Fly    53 A-----------------SCQTCLQQAISFRERCLEVQRELLHSQDDEDFLRICQESPKSVLEQE 100
            .                 .|.||.:   |||:|.......::|:.:..   ..|:|..|..:.:.
Human   299 GRSRLNRHSMVHTAEKPFRCDTCDK---SFRQRSALNSHRMIHTGEKP---YKCEECGKGFICRR 357

  Fly   101 EL--------------------ELDLAEISIEVERLDDLNEGPIQSSGFKVED----ILNESKIN 141
            :|                    ....|...::.:|:.. .|.|     ||.|:    ....|:..
Human   358 DLYTHHMVHTGEKPYNCKECGKSFRWASCLLKHQRVHS-GEKP-----FKCEECGKGFYTNSQCY 416

  Fly   142 EDEPNNEDDIDYS------------EMDY--LIYESDTEVDAKQELKSDSENPKKRRNRRNPRDS 192
            ..:.::..:..|.            ::|:  .::..:...:.|:..||.|..|...::.| ....
Human   417 SHQRSHSGEKPYKCVECGKGYKRRLDLDFHQRVHTGEKLYNCKECGKSFSRAPCLLKHER-LHSG 480

  Fly   193 NRTFFCEECGNHIKDRISFILHCKRHRGVKEFGCEFCEDRFCTPAELKRHIRKHTGEKPFKCRHC 257
            .:.|.|||||...........|.:.|.|.|.:.||.|...:.:...|..|.:.||||:|:.|:.|
Human   481 EKPFQCEECGKRFTQNSHLHSHQRVHTGEKPYKCEKCGKGYNSKFNLDMHQKVHTGERPYNCKEC 545

  Fly   258 SRSFSDYSTRLKHERTHTNERPFVCKECNNAFTTSYILKNHMLVHTGEKAFRCDLCDKLFS---- 318
            .:||...|..|||:|.|:.|:||.|:||...||.:..|.:|..||||||.::||.|.|.||
Human   546 GKSFGWASCLLKHQRLHSGEKPFKCEECGKRFTQNSQLHSHQRVHTGEKPYKCDECGKGFSWSST 610

  Fly   319 RYTHLTTHYRS-----NAHRRNM 336
            |.||...|.|.     ..|.:|:
Human   611 RLTHQRRHSRETPLKCEQHGKNI 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871	20/105 (19%)
		C2H2 Zn finger	198..218	CDD:275368	6/19 (32%)
		COG5048	222..>276	CDD:227381	21/53 (40%)
		C2H2 Zn finger	226..246	CDD:275368	5/19 (26%)
		zf-H2C2_2	238..262	CDD:290200	10/23 (43%)
		C2H2 Zn finger	254..274	CDD:275368	9/19 (47%)
		zf-H2C2_2	269..291	CDD:290200	11/21 (52%)
		C2H2 Zn finger	282..302	CDD:275368	7/19 (37%)
		zf-H2C2_2	295..319	CDD:290200	14/27 (52%)
		C2H2 Zn finger	310..328	CDD:275368	10/21 (48%)
ZNF224	NP_001308574.1	KRAB	8..67	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	178..198	CDD:275368
		COG5048	202..641	CDD:227381	100/413 (24%)
		C2H2 Zn finger	206..226	CDD:275368
		zf-H2C2_2	218..243	CDD:290200	4/8 (50%)
		C2H2 Zn finger	234..254	CDD:275368	7/19 (37%)
		C2H2 Zn finger	262..282	CDD:275368	2/19 (11%)
		zf-H2C2_2	275..297	CDD:290200	5/21 (24%)
		C2H2 Zn finger	290..310	CDD:275368	2/19 (11%)
		C2H2 Zn finger	318..338	CDD:275368	7/22 (32%)
		C2H2 Zn finger	346..366	CDD:275368	4/19 (21%)
		C2H2 Zn finger	374..394	CDD:275368	2/19 (11%)
		C2H2 Zn finger	402..422	CDD:275368	2/19 (11%)
		C2H2 Zn finger	430..450	CDD:275368	1/19 (5%)
		C2H2 Zn finger	458..478	CDD:275368	6/20 (30%)
		zf-H2C2_2	471..495	CDD:290200	7/24 (29%)
		C2H2 Zn finger	486..506	CDD:275368	6/19 (32%)
		C2H2 Zn finger	514..534	CDD:275368	5/19 (26%)
		zf-H2C2_2	526..549	CDD:290200	9/22 (41%)
		C2H2 Zn finger	542..562	CDD:275368	9/19 (47%)
		zf-H2C2_2	555..579	CDD:290200	12/23 (52%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		zf-H2C2_2	585..606	CDD:290200	11/20 (55%)
		C2H2 Zn finger	598..618	CDD:275368	9/19 (47%)
		C2H2 Zn finger	654..674	CDD:275368
		C2H2 Zn finger	682..702	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910