DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and ZBTB17

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_001274532.1	Gene:	ZBTB17 / 7709	HGNCID:	12936	Length:	810	Species:	Homo sapiens

Alignment Length:	262	Identity:	76/262 - (29%)
Similarity:	116/262 - (44%)	Gaps:	44/262 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 ESPKSVLEQEELELDLA----EISIEVERLDDLNEGP--IQSSGFKVEDILNESKINEDEPNNED 149
            |:..|...::|:|::.|    |...|.|..::...||  ::..|.::|        |.:.|...:
Human   211 EAALSESSEQEMEVEPARKGEEEQKEQEEQEEEGAGPAEVKEEGSQLE--------NGEAPEENE 267

  Fly   150 DIDYSEMDYLIYESDTEVDAKQELKSDSENPKKRRNRRNPRDSNRT---------FFCEECGNHI 205
            :           |.....|:.|||.|::      |..|:....:||         ..||:||...
Human   268 N-----------EESAGTDSGQELGSEA------RGLRSGTYGDRTESKAYGSVIHKCEDCGKEF 315

  Fly   206 KDRISFILHCKRHRGVKEFGCEFCEDRFCTPAELKRHIRKHTGEKPFKCRHCSRSFSDYSTRLKH 270
            ....:|..|.:.|.|.|.|.|..|...|..||..|.|.:.|:..||:.|..|.:|:...|....|
Human   316 THTGNFKRHIRIHTGEKPFSCRECSKAFSDPAACKAHEKTHSPLKPYGCEECGKSYRLISLLNLH 380

  Fly   271 ERTHTNERPFVCKECNNAFTTSYILKNHMLVHTGEKAFRCDLCDKLF----SRYTHLTTHYRSNA 331
            ::.|:.|..:.|::|...||||..||.|.|||:|||.::||.|.:.|    |:..||.||.....
Human   381 KKRHSGEARYRCEDCGKLFTTSGNLKRHQLVHSGEKPYQCDYCGRSFSDPTSKMRHLETHDTDKE 445

  Fly   332 HR 333
            |:
Human   446 HK 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871
		C2H2 Zn finger	198..218	CDD:275368	6/19 (32%)
		COG5048	222..>276	CDD:227381	18/53 (34%)
		C2H2 Zn finger	226..246	CDD:275368	7/19 (37%)
		zf-H2C2_2	238..262	CDD:290200	8/23 (35%)
		C2H2 Zn finger	254..274	CDD:275368	5/19 (26%)
		zf-H2C2_2	269..291	CDD:290200	6/21 (29%)
		C2H2 Zn finger	282..302	CDD:275368	10/19 (53%)
		zf-H2C2_2	295..319	CDD:290200	13/27 (48%)
		C2H2 Zn finger	310..328	CDD:275368	9/21 (43%)
ZBTB17	NP_001274532.1	BTB	14..109	CDD:279045
		BTB	25..109	CDD:197585
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..295		22/108 (20%)
		Interaction with MYC	269..308		10/44 (23%)
		COG5048	306..637	CDD:227381	52/142 (37%)
		zf-C2H2	306..328	CDD:278523	6/21 (29%)
		C2H2 Zn finger	308..328	CDD:275368	6/19 (32%)
		zf-H2C2_2	320..344	CDD:290200	8/23 (35%)
		C2H2 Zn finger	336..356	CDD:275368	7/19 (37%)
		C2H2 Zn finger	364..384	CDD:275368	5/19 (26%)
		zf-C2H2	390..412	CDD:278523	10/21 (48%)
		C2H2 Zn finger	392..412	CDD:275368	10/19 (53%)
		zf-H2C2_2	404..428	CDD:290200	12/23 (52%)
		C2H2 Zn finger	420..440	CDD:275368	7/19 (37%)
		zf-C2H2	446..468	CDD:278523	1/2 (50%)
		C2H2 Zn finger	448..468	CDD:275368	76/262 (29%)
		zf-C2H2	475..496	CDD:278523
		C2H2 Zn finger	476..496	CDD:275368
		zf-H2C2_2	488..512	CDD:290200
		C2H2 Zn finger	504..524	CDD:275368
		zf-H2C2_2	516..541	CDD:290200
		C2H2 Zn finger	532..552	CDD:275368
		zf-H2C2_2	544..569	CDD:290200
		C2H2 Zn finger	560..580	CDD:275368
		zf-H2C2_2	573..597	CDD:290200
		C2H2 Zn finger	588..608	CDD:275368
		zf-H2C2_2	600..625	CDD:290200
		C2H2 Zn finger	616..635	CDD:275370
		C2H2 Zn finger	726..746	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	786..810
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910