DRSC/TRiP Functional Genomics Resources

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Protein Alignment ranshi and ZNF221

DIOPT Version :9

Sequence 1:NP_649824.1 Gene:ranshi / 41041 FlyBaseID:FBgn0037620 Length:346 Species:Drosophila melanogaster
Sequence 2:NP_001284517.1 Gene:ZNF221 / 7638 HGNCID:13014 Length:617 Species:Homo sapiens


Alignment Length:353 Identity:91/353 - (25%)
Similarity:135/353 - (38%) Gaps:72/353 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 CRTCGKRTNAERSLNIFEKRNQTTLEHIKLLTGAVLKNCSTLPNRLCASCQTCLQQAISFRERCL 70
            |..|||..::..:||:          |.||.||....||                      |.| 
Human   256 CGQCGKGFHSRSALNV----------HCKLHTGEKPYNC----------------------EEC- 287

  Fly    71 EVQRELLHSQDDEDFLRI-CQESPKSVLEQEELELDLAEISIEVERLDDLNEGPIQSSGFKVE-- 132
              .:..:|....::..|| ..|.|        .:.|:...|..|.  ..||...:..:|.|..  
Human   288 --GKAFIHDSQLQEHQRIHTGEKP--------FKCDICGKSFRVR--SRLNRHSMVHTGEKPFRC 340

  Fly   133 DILNESKINEDEPNNEDDIDYSEMDY--------LIYESDTEVDAKQELKSDSENPKKRR----- 184
            |...::.......|:...:...|..|        .|...|.   .|.::....|.|...:     
Human   341 DTCGKNFRQRSALNSHSMVHIEEKPYKCEQCGKGFICRRDF---CKHQMVHTGEKPYNCKECGKT 402

  Fly   185 --------NRRNPRDSNRTFFCEECGNHIKDRISFILHCKRHRGVKEFGCEFCEDRFCTPAELKR 241
                    |.:......::|.|||||...........|.:.|.|.|.:.||.|...:....:|:.
Human   403 FRWSSCLLNHQQVHSGQKSFKCEECGKGFYTNSRRSSHQRSHNGEKPYNCEECGKDYKRRLDLEF 467

  Fly   242 HIRKHTGEKPFKCRHCSRSFSDYSTRLKHERTHTNERPFVCKECNNAFTTSYILKNHMLVHTGEK 306
            |.|.||||:|:.|:.|.:||...|..|||:|.|:.|:||.|:||...||.|..|.:|...|||||
Human   468 HQRVHTGERPYNCKECGKSFGWASCLLKHQRLHSGEKPFKCEECGKRFTQSSQLHSHQTCHTGEK 532

  Fly   307 AFRCDLCDKLFSRYTHLTTHYRSNAHRR 334
            .::|:.|:|.::...:|..|.|.:...|
Human   533 LYKCEQCEKGYNSKFNLDMHQRVHGGER 560

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ranshiNP_649824.1 zf-AD 5..77 CDD:214871 15/70 (21%)
C2H2 Zn finger 198..218 CDD:275368 6/19 (32%)
COG5048 222..>276 CDD:227381 22/53 (42%)
C2H2 Zn finger 226..246 CDD:275368 6/19 (32%)
zf-H2C2_2 238..262 CDD:290200 11/23 (48%)
C2H2 Zn finger 254..274 CDD:275368 9/19 (47%)
zf-H2C2_2 269..291 CDD:290200 11/21 (52%)
C2H2 Zn finger 282..302 CDD:275368 8/19 (42%)
zf-H2C2_2 295..319 CDD:290200 10/23 (43%)
C2H2 Zn finger 310..328 CDD:275368 5/17 (29%)
ZNF221NP_001284517.1 KRAB 30..70 CDD:307490
COG5048 166..576 CDD:227381 91/353 (26%)
C2H2 Zn finger 172..192 CDD:275368
C2H2 Zn finger 200..220 CDD:275368
C2H2 Zn finger 228..248 CDD:275368
C2H2 Zn finger 256..276 CDD:275368 8/29 (28%)
C2H2 Zn finger 284..304 CDD:275368 5/44 (11%)
C2H2 Zn finger 312..332 CDD:275368 5/21 (24%)
C2H2 Zn finger 340..360 CDD:275368 2/19 (11%)
C2H2 Zn finger 368..388 CDD:275368 3/22 (14%)
C2H2 Zn finger 396..416 CDD:275368 1/19 (5%)
C2H2 Zn finger 424..444 CDD:275368 6/19 (32%)
C2H2 Zn finger 452..472 CDD:275368 6/19 (32%)
C2H2 Zn finger 480..500 CDD:275368 9/19 (47%)
C2H2 Zn finger 508..528 CDD:275368 8/19 (42%)
C2H2 Zn finger 536..556 CDD:275368 6/19 (32%)
C2H2 Zn finger 564..584 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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