DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and ZNF84

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_001120844.1	Gene:	ZNF84 / 7637	HGNCID:	13159	Length:	738	Species:	Homo sapiens

Alignment Length:	369	Identity:	94/369 - (25%)
Similarity:	143/369 - (38%)	Gaps:	84/369 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CRTCGKRTNAERSLNIFEKRNQTTLEHIKLLTGAVLKNCSTLPNRL------------------- 51
            ||.|||         .|.:::|....| :..||.....||......
Human   349 CRECGK---------AFSRKSQLVTHH-RTHTGTKPFGCSDCRKAFFEKSELIRHQTIHTGEKPY 403

  Fly    52 -CASCQT----------------------CLQQAISFRERCLEVQRELLHSQDDEDFLRICQESP 93
             |:.|:.                      |:|...:|.::...:..::.|: .::.|  ||.:..
Human   404 ECSECRKAFRERSSLINHQRTHTGEKPHGCIQCGKAFSQKSHLISHQMTHT-GEKPF--ICSKCG 465

  Fly    94 KSVLEQEELELDLAEISIEVERLDDLNEGPIQSS--GFKVEDILNESKINEDEPNNEDDIDYSEM 156
            |:...:.:|        :..:| ....|.|.:.|  |....:.|:.:        |...|...|.
Human   466 KAFSRKSQL--------VRHQR-THTGEKPYECSECGKAFSEKLSLT--------NHQRIHTGEK 513

  Fly   157 DYLIYESDTEVDAKQELKSDSENPKKRRNRRNPRDSNRTFFCEECGNHIKDRISFILHCKRHRGV 221
            .|:..|.......|..|.|          .:......:.:.|.|||....::.|...|.:.|.|.
Human   514 PYVCSECGKAFCQKSHLIS----------HQRTHTGEKPYECSECGKAFGEKSSLATHQRTHTGE 568

  Fly   222 KEFGCEFCEDRFCTPAELKRHIRKHTGEKPFKCRHCSRSFSDYSTRLKHERTHTNERPFVCKECN 286
            |.:.|..||..|...::|..|.|.||||||::|..|.::|.:.|..::|.||||.|:|:.|.||.
Human   569 KPYECRDCEKAFSQKSQLNTHQRIHTGEKPYECSLCRKAFFEKSELIRHLRTHTGEKPYECNECR 633

  Fly   287 NAFTTSYILKNHMLVHTGEKAFRCDLCDKLFSRYTHLTTHYRSN 330
            .||.....|.||..:|||||.|.|..|.|.|||.:||..|.|::
Human   634 KAFREKSSLINHQRIHTGEKPFECSECGKAFSRKSHLIPHQRTH 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871	17/112 (15%)
		C2H2 Zn finger	198..218	CDD:275368	6/19 (32%)
		COG5048	222..>276	CDD:227381	22/53 (42%)
		C2H2 Zn finger	226..246	CDD:275368	7/19 (37%)
		zf-H2C2_2	238..262	CDD:290200	11/23 (48%)
		C2H2 Zn finger	254..274	CDD:275368	6/19 (32%)
		zf-H2C2_2	269..291	CDD:290200	12/21 (57%)
		C2H2 Zn finger	282..302	CDD:275368	8/19 (42%)
		zf-H2C2_2	295..319	CDD:290200	13/23 (57%)
		C2H2 Zn finger	310..328	CDD:275368	9/17 (53%)
ZNF84	NP_001120844.1	KRAB	9..68	CDD:214630
		C2H2 Zn finger	209..229	CDD:275368
		C2H2 Zn finger	237..257	CDD:275368
		C2H2 Zn finger	265..285	CDD:275368
		zf-H2C2_2	278..302	CDD:316026
		C2H2 Zn finger	293..313	CDD:275368
		COG5048	317..724	CDD:227381	94/369 (25%)
		C2H2 Zn finger	321..341	CDD:275368
		C2H2 Zn finger	349..369	CDD:275368	8/29 (28%)
		C2H2 Zn finger	377..397	CDD:275368	2/19 (11%)
		C2H2 Zn finger	405..425	CDD:275368	2/19 (11%)
		C2H2 Zn finger	433..453	CDD:275368	3/19 (16%)
		C2H2 Zn finger	461..481	CDD:275368	4/28 (14%)
		C2H2 Zn finger	489..509	CDD:275368	4/27 (15%)
		C2H2 Zn finger	517..537	CDD:275368	4/29 (14%)
		C2H2 Zn finger	545..565	CDD:275368	6/19 (32%)
		C2H2 Zn finger	573..593	CDD:275368	7/19 (37%)
		C2H2 Zn finger	601..621	CDD:275368	6/19 (32%)
		C2H2 Zn finger	629..649	CDD:275368	8/19 (42%)
		C2H2 Zn finger	657..677	CDD:275368	10/19 (53%)
		C2H2 Zn finger	685..705	CDD:275368
		C2H2 Zn finger	713..733	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910