DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ranshi and ZNF70

DIOPT Version :9

Sequence 1:NP_649824.1 Gene:ranshi / 41041 FlyBaseID:FBgn0037620 Length:346 Species:Drosophila melanogaster
Sequence 2:NP_068735.1 Gene:ZNF70 / 7621 HGNCID:13140 Length:446 Species:Homo sapiens


Alignment Length:329 Identity:82/329 - (24%)
Similarity:113/329 - (34%) Gaps:80/329 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 CRTCGKRTNAERSLNIFEKRNQTTLEHIKLLTGAVLKNCSTLPNRLCASCQTCLQQAISFRERCL 70
            ||.|||..:....|          |.|:.:.||.....|.........|......|.|...|:..
Human   142 CRECGKAFSQSSHL----------LRHLVIHTGEKPYECCECGKAFSQSSHLLRHQIIHTGEKPY 196

  Fly    71 EVQRELLHSQDDEDFLRICQESPKSVLEQEELELDLAEISIEVERLDDLNEGPIQSSGFKVEDIL 135
            |                 |:|..|:..                           |||.......:
Human   197 E-----------------CRECGKAFR---------------------------QSSALTQHQKI 217

  Fly   136 NESKINEDEPNNEDDIDYSEMDYLIYESDTEVDAKQELKSDSENPKKRRNRRNPRDSNRTFFCEE 200
            :..|    .|               ||.       :|...|.......|.........|.:.|:|
Human   218 HTGK----RP---------------YEC-------RECGKDFSRSSSLRKHERIHTGERPYQCKE 256

  Fly   201 CGNHIKDRISFILHCKRHRGVKEFGCEFCEDRFCTPAELKRHIRKHTGEKPFKCRHCSRSFSDYS 265
            ||...........|.|.|...|...|:.|...||..:.|.||.|.|||:||:||..|.::||..|
Human   257 CGKSFNQSSGLSQHRKIHTLKKPHECDLCGKAFCHRSHLIRHQRIHTGKKPYKCDECGKAFSQSS 321

  Fly   266 TRLKHERTHTNERPFVCKECNNAFTTSYILKNHMLVHTGEKAFRCDLCDKLFSRYTHLTTHYRSN 330
            ..::|.:|||.|:|:.|::|..||:.|..|..|..:|||||.:.|..|.|.|...:.|..|.|.:
Human   322 NLIEHRKTHTGEKPYKCQKCGKAFSQSSSLIEHQRIHTGEKPYECCQCGKAFCHSSALIQHQRIH 386

  Fly   331 AHRR 334
            ..::
Human   387 TGKK 390

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ranshiNP_649824.1 zf-AD 5..77 CDD:214871 16/70 (23%)
C2H2 Zn finger 198..218 CDD:275368 6/19 (32%)
COG5048 222..>276 CDD:227381 23/53 (43%)
C2H2 Zn finger 226..246 CDD:275368 8/19 (42%)
zf-H2C2_2 238..262 CDD:290200 12/23 (52%)
C2H2 Zn finger 254..274 CDD:275368 6/19 (32%)
zf-H2C2_2 269..291 CDD:290200 10/21 (48%)
C2H2 Zn finger 282..302 CDD:275368 7/19 (37%)
zf-H2C2_2 295..319 CDD:290200 11/23 (48%)
C2H2 Zn finger 310..328 CDD:275368 6/17 (35%)
ZNF70NP_068735.1 C2H2 Zn finger 92..108 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 114..138
COG5048 138..442 CDD:227381 82/329 (25%)
C2H2 Zn finger 142..162 CDD:275368 8/29 (28%)
C2H2 Zn finger 170..190 CDD:275368 3/19 (16%)
C2H2 Zn finger 198..218 CDD:275368 6/46 (13%)
C2H2 Zn finger 226..246 CDD:275368 3/26 (12%)
C2H2 Zn finger 254..274 CDD:275368 6/19 (32%)
C2H2 Zn finger 282..302 CDD:275368 8/19 (42%)
C2H2 Zn finger 310..330 CDD:275368 6/19 (32%)
C2H2 Zn finger 338..358 CDD:275368 7/19 (37%)
C2H2 Zn finger 366..386 CDD:275368 7/19 (37%)
C2H2 Zn finger 394..413 CDD:275368
C2H2 Zn finger 421..441 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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