DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and ZNF45

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_003416.1	Gene:	ZNF45 / 7596	HGNCID:	13111	Length:	682	Species:	Homo sapiens

Alignment Length:	326	Identity:	89/326 - (27%)
Similarity:	139/326 - (42%)	Gaps:	72/326 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 ELLHSQDDEDFLRICQESPKSVLEQEELELDLAEISIEVERLDDL---NEG-PIQSSGFKVEDIL 135
            ||..||       |.|:..:.:::.::..:::.....::|:.|||   :|| ..|||..:|..:.
Human   101 ELFCSQ-------IWQQITRELIKYQDSVVNIQRTGCQLEKRDDLHYKDEGFSNQSSHLQVHRVH 158

  Fly   136 NESK------------------INE-----DEPNNEDDID----------------------YSE 155
            ...|                  ||:     ::|...:..|                      .::
Human   159 TGEKPYKGEHCVKSFSWSSHLQINQRAHAGEKPYKCEKCDNAFRRFSSLQAHQRVHSRAKSYTND 223

  Fly   156 MDYLIYESDTEVDAKQELKSDSENPKKRRN-RRNPRDSN------------RTFFCEECGNHIKD 207
            ..|..:...:.:...|.:.: .|||.|... .||...|:            :.:.|||||.....
Human   224 ASYRSFSQRSHLPHHQRVPT-GENPYKYEECGRNVGKSSHCQAPLIVHTGEKPYKCEECGVGFSQ 287

  Fly   208 RISFILHCKRHRGVKEFGCEFCEDRFCTPAELKRHIRKHTGEKPFKCRHCSRSFSDYSTRLK-HE 271
            |....:|.|.|.|.|.:.||.|...|...:.|:.|.|.||||||:||..|.:||| ||:.|. |.
Human   288 RSYLQVHLKVHTGKKPYKCEECGKSFSWRSRLQAHERIHTGEKPYKCNACGKSFS-YSSHLNIHC 351

  Fly   272 RTHTNERPFVCKECNNAFTTSYILKNHMLVHTGEKAFRCDLCDKLFSRYTHLTTHYRSNAHRRNM 336
            |.||.|:|:.|:||...|:....|:.|.:.|||||.::|:.|.|.|.|.::|..|.|.:...:..
Human   352 RIHTGEKPYKCEECGKGFSVGSHLQAHQISHTGEKPYKCEECGKGFCRASNLLDHQRGHTGEKPY 416

  Fly   337 Q 337
            |
Human   417 Q 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871	1/1 (100%)
		C2H2 Zn finger	198..218	CDD:275368	8/19 (42%)
		COG5048	222..>276	CDD:227381	26/54 (48%)
		C2H2 Zn finger	226..246	CDD:275368	7/19 (37%)
		zf-H2C2_2	238..262	CDD:290200	13/23 (57%)
		C2H2 Zn finger	254..274	CDD:275368	10/20 (50%)
		zf-H2C2_2	269..291	CDD:290200	10/22 (45%)
		C2H2 Zn finger	282..302	CDD:275368	6/19 (32%)
		zf-H2C2_2	295..319	CDD:290200	11/23 (48%)
		C2H2 Zn finger	310..328	CDD:275368	7/17 (41%)
ZNF45	NP_003416.1	KRAB	8..67	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	166..186	CDD:275368	2/19 (11%)
		COG5048	190..602	CDD:227381	70/230 (30%)
		C2H2 Zn finger	194..214	CDD:275368	1/19 (5%)
		C2H2 Zn finger	251..270	CDD:275368	3/18 (17%)
		C2H2 Zn finger	278..298	CDD:275368	8/19 (42%)
		zf-H2C2_2	290..314	CDD:290200	8/23 (35%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		zf-H2C2_2	319..343	CDD:290200	15/24 (63%)
		C2H2 Zn finger	334..354	CDD:275368	10/20 (50%)
		zf-H2C2_2	346..370	CDD:290200	10/23 (43%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		zf-H2C2_2	374..397	CDD:290200	10/22 (45%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		zf-H2C2_2	402..427	CDD:290200	4/16 (25%)
		C2H2 Zn finger	418..438	CDD:275368	89/326 (27%)
		zf-H2C2_2	430..455	CDD:290200
		C2H2 Zn finger	446..466	CDD:275368
		zf-H2C2_2	458..483	CDD:290200
		C2H2 Zn finger	474..494	CDD:275368
		zf-H2C2_2	486..511	CDD:290200
		C2H2 Zn finger	502..522	CDD:275368
		zf-H2C2_2	514..538	CDD:290200
		C2H2 Zn finger	530..550	CDD:275368
		zf-H2C2_2	543..565	CDD:290200
		C2H2 Zn finger	558..578	CDD:275368
		zf-H2C2_2	570..595	CDD:290200
		zf-C2H2	584..606	CDD:278523
		C2H2 Zn finger	586..606	CDD:275368
		zf-H2C2_2	598..622	CDD:290200
		C2H2 Zn finger	614..634	CDD:275368
		zf-H2C2_2	626..650	CDD:290200
		C2H2 Zn finger	642..662	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	662..682
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910