DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ranshi and ZNF8

DIOPT Version :9

Sequence 1:NP_649824.1 Gene:ranshi / 41041 FlyBaseID:FBgn0037620 Length:346 Species:Drosophila melanogaster
Sequence 2:NP_066575.2 Gene:ZNF8 / 7554 HGNCID:13154 Length:575 Species:Homo sapiens


Alignment Length:271 Identity:84/271 - (30%)
Similarity:124/271 - (45%) Gaps:39/271 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    87 RICQESPKSVLEQEEL-ELDLAEISIEVERLDDLNEGPIQSSGFKVEDILNESKINEDEPNNEDD 150
            |.||....::.||..| :|:..           |.|.|:|..|:|... |.|:.:....||...:
Human   141 RECQSQSLALKEQNNLKQLEFG-----------LKEAPVQDQGYKTLR-LRENCVLSSSPNPFPE 193

  Fly   151 IDYSEMDYLIYES---DTEVDA---KQELKSDSENPKKRRNRRNPRDS---------------NR 194
            |...|..| .|:|   |:|.::   .|:..|..:.|.:  |....|||               ::
Human   194 ISRGEYLY-TYDSQITDSEHNSSLVSQQTGSPGKQPGE--NSDCHRDSSQAIPITELTKSQVQDK 255

  Fly   195 TFFCEECGNHIKDRISFILHCKRHRGVKEFGCEFCEDRFCTPAELKRHIRKHTGEKPFKCRHCSR 259
            .:.|.:||..........:|.:.|.|.:.:.|:.|...|...:.|.:|.|.|||:||:||..|.:
Human   256 PYKCTDCGKSFNHNAHLTVHKRIHTGERPYMCKECGKAFSQNSSLVQHERIHTGDKPYKCAECGK 320

  Fly   260 SFSDYSTRLK-HERTHTNERPFVCKECNNAFTTSYILKNHMLVHTGEKAFRCDLCDKLFSRYTHL 323
            ||. :||.|. |.|.||.|:|:.|::|..||..:..|..|...|||||.:.|.:|.|.|||.|.|
Human   321 SFC-HSTHLTVHRRIHTGEKPYECQDCGRAFNQNSSLGRHKRTHTGEKPYTCSVCGKSFSRTTCL 384

  Fly   324 TTHYRSNAHRR 334
            ..|.|::...|
Human   385 FLHLRTHTEER 395

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ranshiNP_649824.1 zf-AD 5..77 CDD:214871
C2H2 Zn finger 198..218 CDD:275368 4/19 (21%)
COG5048 222..>276 CDD:227381 22/54 (41%)
C2H2 Zn finger 226..246 CDD:275368 6/19 (32%)
zf-H2C2_2 238..262 CDD:290200 12/23 (52%)
C2H2 Zn finger 254..274 CDD:275368 9/20 (45%)
zf-H2C2_2 269..291 CDD:290200 10/22 (45%)
C2H2 Zn finger 282..302 CDD:275368 6/19 (32%)
zf-H2C2_2 295..319 CDD:290200 11/23 (48%)
C2H2 Zn finger 310..328 CDD:275368 9/17 (53%)
ZNF8NP_066575.2 KRAB 25..85 CDD:214630
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 92..130
COG5048 <167..404 CDD:227381 75/234 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 210..237 5/28 (18%)
C2H2 Zn finger 259..279 CDD:275368 4/19 (21%)
C2H2 Zn finger 287..307 CDD:275368 6/19 (32%)
C2H2 Zn finger 315..335 CDD:275368 9/20 (45%)
C2H2 Zn finger 343..363 CDD:275368 6/19 (32%)
C2H2 Zn finger 371..391 CDD:275368 10/19 (53%)
zf-C2H2 397..419 CDD:306579
C2H2 Zn finger 399..419 CDD:275368
zf-C2H2 467..489 CDD:306579
C2H2 Zn finger 469..489 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 488..533
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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