DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and ZNF878

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	XP_016882684.1	Gene:	ZNF878 / 729747	HGNCID:	37246	Length:	567	Species:	Homo sapiens

Alignment Length:	328	Identity:	82/328 - (25%)
Similarity:	134/328 - (40%)	Gaps:	58/328 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CRTCGKRTNAERSLNIFEKRNQTTLEHIKLLTGAVLKNCSTLPNRLCASCQTCLQQAISFRERCL 70
            |:.|||..:...|:...|:.:.....:                  .|..|...|...:||:...
Human   209 CKQCGKAFSFPSSVRRHERIHSAKKPY------------------ECKQCGKALSYLVSFQTHM- 254

  Fly    71 EVQRELLHSQDDEDFLRICQE---SPKSVLEQEELELDLAEISIEVERLDDLNEGPIQSSGFKVE 132
                 .:|:.:......||.:   ||.|:...|:..  ..|...:.::.|.....|   |.|:
Human   255 -----RMHTGERPHKCNICGKAFFSPSSLKRHEKSH--TGEKRYKCKQCDKAFNCP---SSFQ-- 307

  Fly   133 DILNESKINEDEPNNEDDIDYSEMDYLIYESDTEVDAKQELKSDSENPKKRRNRRNPRDSNRTFF 197
              .:|...:.::|               ||.       .:.:....:.|..|.........:.:.
Human   308 --YHERTHSGEKP---------------YEC-------TQCRKAFRSVKYLRVHERKHTGEKPYE 348

  Fly   198 CEECGNHIKDRISFILHCKRHRGVKEFGCEFCEDRFCTPAELKRHIRKHTGEKPFKCRHCSRSFS 262
            |:.||.......||..|.|.|.|.|.:.|:.|...|....:|:.|.|.|||||||:|:.|.::|:
Human   349 CKLCGKGFISSTSFRYHEKTHTGEKPYECKKCVKAFSFVKDLRIHERTHTGEKPFECKQCGKTFT 413

  Fly   263 DYSTRLKHERTHTNERPFVCKECNNAFTTSYILKNHMLVHTGEKAFRCDLCDKLFSRYTHLTTHY 327
            ..::...||||||.|:|:.||:|..||.::.:|:.|:..|||||.:.|..|.|:|...:.|..|.
Human   414 SSNSFHYHERTHTGEKPYECKQCGKAFRSASVLQKHIRTHTGEKPYGCKQCGKVFRVASQLKMHE 478

  Fly   328 RSN 330
            |::
Human   479 RTH 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871	11/70 (16%)
		C2H2 Zn finger	198..218	CDD:275368	7/19 (37%)
		COG5048	222..>276	CDD:227381	22/53 (42%)
		C2H2 Zn finger	226..246	CDD:275368	6/19 (32%)
		zf-H2C2_2	238..262	CDD:290200	12/23 (52%)
		C2H2 Zn finger	254..274	CDD:275368	6/19 (32%)
		zf-H2C2_2	269..291	CDD:290200	13/21 (62%)
		C2H2 Zn finger	282..302	CDD:275368	7/19 (37%)
		zf-H2C2_2	295..319	CDD:290200	11/23 (48%)
		C2H2 Zn finger	310..328	CDD:275368	6/17 (35%)
ZNF878	XP_016882684.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	0.118	Domainoid score	I11437
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000