DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and Zfp40

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	XP_038947408.1	Gene:	Zfp40 / 690661	RGDID:	1593410	Length:	828	Species:	Rattus norvegicus

Alignment Length:	390	Identity:	94/390 - (24%)
Similarity:	146/390 - (37%)	Gaps:	103/390 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CRTCGKRTNAERSL-------------------NIFEKRNQTTLEHIKLLTGAVLKNCS------ 45
            |..|||..::...|                   ..|.:::|.. .|.|:.||.....||
  Rat   397 CNECGKSLSSSSGLQRHQRIHRGEKAYICAECDKCFIQKSQLK-THQKIHTGEKSYKCSECEKSF 460

  Fly    46 TLPNRL--------------CASCQTCLQQAISFRE-----------RCLEVQRELLHSQDDEDF 85
            |:.:.|              |:.|..|..|....|.           :|.|.::......|
  Rat   461 TVGSSLRIHQRIHTGEKPYKCSECHKCFIQQAHLRRHQKIHTGEKPYKCSECEKSFTVGSD---- 521

  Fly    86 LRI------------CQESPKSVLEQEELELDLAEISIEVERLDDLNEGPIQSSGFK-----VED 133
            ||:            |.:..|..:::.:|:        :.:|: ...|.|.:.|..:     |.|
  Rat   522 LRMHQKIHTGEKPYKCSDCDKCFIQKAKLK--------KHQRI-HTGEKPYKCSECEKCFTVVSD 577

  Fly   134 ILNESKINEDEPNNEDDIDYSEMDYLIYESDTEVDAKQELKSDSENPKKRRNRRNPRDSNRTFFC 198
            :....||:.           .|..|...|.|.....|..|         ||:.| .....:.:.|
  Rat   578 LRTHQKIHT-----------GEKPYKCSECDKCFIRKANL---------RRHHR-IHTGEKPYKC 621

  Fly   199 EECGNHIKDRISFILHCKRHRGVKEFGCEFCEDRFCTPAELKRHIRKHTGEKPFKCRHCSRSFSD 263
            .:||.....:.:...|.:.|.|.|.:.|| |...|...::|::|.:.||||||:||..|.:.|..
  Rat   622 SDCGKCFIQKANLRTHERIHTGEKPYKCE-CGKSFSVGSDLRKHQKCHTGEKPYKCSECHKCFIR 685

  Fly   264 YSTRLKHERTHTNERPFVCKECNNAFTTSYILKNHMLVHTGEKAFRCDLCDKLFSRYTHLTTHYR 328
            .:...:|:|.||.|:|:.|.:|...|.....|:.|..:|||||.::|..|||.|.:..||.||.|
  Rat   686 KAHLRRHQRIHTGEKPYKCSDCGKCFIQKANLRTHQKIHTGEKPYKCSDCDKCFIQKDHLRTHQR 750

Fly 329 328
Rat 751 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871	22/120 (18%)
		C2H2 Zn finger	198..218	CDD:275368	4/19 (21%)
		COG5048	222..>276	CDD:227381	20/53 (38%)
		C2H2 Zn finger	226..246	CDD:275368	6/19 (32%)
		zf-H2C2_2	238..262	CDD:290200	11/23 (48%)
		C2H2 Zn finger	254..274	CDD:275368	5/19 (26%)
		zf-H2C2_2	269..291	CDD:290200	9/21 (43%)
		C2H2 Zn finger	282..302	CDD:275368	5/19 (26%)
		zf-H2C2_2	295..319	CDD:290200	12/23 (52%)
		C2H2 Zn finger	310..328	CDD:275368	9/17 (53%)
Zfp40	XP_038947408.1	KRAB	73..>115	CDD:214630
		C2H2 Zn finger	257..277	CDD:275368
		C2H2 Zn finger	285..305	CDD:275368
		COG5048	309..709	CDD:227381	76/347 (22%)
		C2H2 Zn finger	313..333	CDD:275368
		C2H2 Zn finger	341..361	CDD:275368
		C2H2 Zn finger	369..389	CDD:275368
		C2H2 Zn finger	397..417	CDD:275368	5/19 (26%)
		C2H2 Zn finger	425..445	CDD:275368	4/20 (20%)
		C2H2 Zn finger	453..473	CDD:275368	4/19 (21%)
		C2H2 Zn finger	481..501	CDD:275368	5/19 (26%)
		C2H2 Zn finger	509..529	CDD:275368	5/23 (22%)
		C2H2 Zn finger	537..557	CDD:275368	4/28 (14%)
		C2H2 Zn finger	565..585	CDD:275368	4/19 (21%)
		C2H2 Zn finger	593..613	CDD:275368	7/29 (24%)
		C2H2 Zn finger	621..641	CDD:275368	4/19 (21%)
		C2H2 Zn finger	650..668	CDD:275368	5/18 (28%)
		C2H2 Zn finger	676..696	CDD:275368	5/19 (26%)
		C2H2 Zn finger	704..724	CDD:275368	5/19 (26%)
		zf-H2C2_2	716..741	CDD:404364	12/24 (50%)
		C2H2 Zn finger	732..752	CDD:275368	10/19 (53%)
		zf-H2C2_2	744..768	CDD:404364	5/7 (71%)
		C2H2 Zn finger	760..780	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11351
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000