DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and ZNF674

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_001034980.1	Gene:	ZNF674 / 641339	HGNCID:	17625	Length:	581	Species:	Homo sapiens

Alignment Length:	344	Identity:	86/344 - (25%)
Similarity:	136/344 - (39%)	Gaps:	73/344 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CRTCGK------------RTN-AERSLNIFE-----KRNQTTLEHIKLLTGAVLKNCSTLPNRLC 52
            |..|||            ||: .|:.....|     .:..|.:.|.:..||.....||.     |
Human   226 CTECGKVFIQKANLVVHQRTHTGEKPYECCECAKAFSQKSTLIAHQRTHTGEKPYECSE-----C 285

  Fly    53 ASCQTCLQQAISFRERCLEVQRELLHSQDDEDFLRICQESPKSVLEQEELELDLAEISIEVERLD 117
            ..         :|.::...::.:..|: .::.|  :|.:.||:......|        |..|:..
Human   286 GK---------TFIQKSTLIKHQRTHT-GEKPF--VCDKCPKAFKSSYHL--------IRHEKTH 330

  Fly   118 DLNEGPIQSSGFKVEDILNESKINEDEPNNEDDIDYSEMDYLIYE---SDTEVDAKQELKSDSEN 179
                  |:.:.:|.......|                    |||:   :..:....:..|:..|.
Human   331 ------IRQAFYKGIKCTTSS--------------------LIYQRIHTSEKPQCSEHGKASDEK 369

  Fly   180 PKKRRNRRNPRDSNRTFFCEECGNHIKDRISFILHCKRHRGVKEFGCEFCEDRFCTPAELKRHIR 244
            |...::.|.....| .:.|.:||...:.:....:|.:.|.|.|.:.|..|...|...:.|..|.|
Human   370 PSPTKHWRTHTKEN-IYECSKCGKSFRGKSHLSVHQRIHTGEKPYECSICGKTFSGKSHLSVHHR 433

  Fly   245 KHTGEKPFKCRHCSRSFSDYSTRLKHERTHTNERPFVCKECNNAFTTSYILKNHMLVHTGEKAFR 309
            .||||||::||.|.::|.:.||.:.|:|.||.|:|:.|.||..||:....|..|..:||||:.:.
Human   434 THTGEKPYECRRCGKAFGEKSTLIVHQRMHTGEKPYKCNECGKAFSEKSPLIKHQRIHTGERPYE 498

  Fly   310 CDLCDKLFSRYTHLTTHYR 328
            |..|.|.|||.:.|..|.|
Human   499 CTDCKKAFSRKSTLIKHQR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871	16/88 (18%)
		C2H2 Zn finger	198..218	CDD:275368	4/19 (21%)
		COG5048	222..>276	CDD:227381	22/53 (42%)
		C2H2 Zn finger	226..246	CDD:275368	6/19 (32%)
		zf-H2C2_2	238..262	CDD:290200	12/23 (52%)
		C2H2 Zn finger	254..274	CDD:275368	8/19 (42%)
		zf-H2C2_2	269..291	CDD:290200	11/21 (52%)
		C2H2 Zn finger	282..302	CDD:275368	7/19 (37%)
		zf-H2C2_2	295..319	CDD:290200	10/23 (43%)
		C2H2 Zn finger	310..328	CDD:275368	8/17 (47%)
ZNF674	NP_001034980.1	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		COG5048	190..580	CDD:227381	86/344 (25%)
		C2H2 Zn finger	202..218	CDD:275368
		zf-C2H2	224..246	CDD:278523	5/19 (26%)
		C2H2 Zn finger	226..246	CDD:275368	5/19 (26%)
		zf-H2C2_2	238..263	CDD:290200	4/24 (17%)
		C2H2 Zn finger	254..274	CDD:275368	3/19 (16%)
		zf-C2H2	280..302	CDD:278523	4/35 (11%)
		C2H2 Zn finger	282..302	CDD:275368	4/33 (12%)
		zf-H2C2_2	295..319	CDD:290200	5/26 (19%)
		C2H2 Zn finger	310..330	CDD:275368	6/27 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..377		3/19 (16%)
		C2H2 Zn finger	387..407	CDD:275368	4/19 (21%)
		zf-H2C2_2	399..423	CDD:290200	6/23 (26%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		zf-H2C2_2	427..450	CDD:290200	12/22 (55%)
		C2H2 Zn finger	443..463	CDD:275368	8/19 (42%)
		zf-H2C2_2	456..479	CDD:290200	10/22 (45%)
		C2H2 Zn finger	471..491	CDD:275368	7/19 (37%)
		zf-H2C2_2	484..508	CDD:290200	10/23 (43%)
		C2H2 Zn finger	499..519	CDD:275368	9/19 (47%)
		zf-H2C2_2	512..535	CDD:290200	3/6 (50%)
		C2H2 Zn finger	527..547	CDD:275368
		zf-H2C2_2	540..563	CDD:290200
		C2H2 Zn finger	555..575	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910