DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and fezf2

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_001016305.1	Gene:	fezf2 / 549059	XenbaseID:	XB-GENE-1006432	Length:	435	Species:	Xenopus tropicalis

Alignment Length:	364	Identity:	92/364 - (25%)
Similarity:	142/364 - (39%)	Gaps:	52/364 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GKRTNAERSLNI--------------FEKRNQTTLEHIKL----LTGAVLKNCSTLPNRLCAS-C 55
            |....|::.||:              ::..::..|.:.:|    |.|:|   ||  |:.||.| |
Frog    52 GLDPGAKKMLNLCSPLPCMIPIQSLAYDVHSKALLNYSELWKSSLRGSV---CS--PSGLCKSNC 111

  Fly    56 QTCLQQAISFRERCLEVQREL----------LHSQDDEDFLRICQES--PKSVLEQEELELDLAE 108
            ..|.:..::.....|...|.:          |.:.....:......|  |..:|..:.|...|
Frog   112 GICCKNDLNMGHTVLPGSRVIKPQVINQTVGLPTNGSLYYFNYLDSSFHPPEILSGQLLSSSL-- 174

  Fly   109 ISIEVERLDDLNEGPIQSSGFKVEDILNESKINEDEPNNEDDIDYSEMDYLIYESDTEVDAKQEL 173
              |..:....|:   .|...|    :|..:|::...|....:..|...:.|..:.|..:.....|
Frog   175 --INAQSQATLS---AQQKLF----LLENAKLSGLAPEKFPNPQYPHKERLPGQLDQVMKENSAL 230

  Fly   174 KSDSENPKKRRNRRNPRDSN-RTFFCEECGNHIKDRISFILHCKRHRGVKEFGCEFCEDRFCTPA 237
            .:|.......:...|..:.. :.|.||.||.......:...|...|.|.:.|.|:.|...|...:
Frog   231 SADRSGKIHSKLGANSAEGKPKIFTCEVCGKVFNAHYNLTRHMPVHTGARPFVCKVCGKGFRQAS 295

  Fly   238 ELKRHIRKHTGEKPFKCRHCSRSFSDYSTRLKHERTHTNERPFVCKECNNAFTTSYILKNHMLVH 302
            .|.||...||.|||.||..|.::|:..||...|.|.|...:||||:.|...|......|||.|.|
Frog   296 TLCRHKIIHTQEKPHKCNQCGKAFNRSSTLNTHIRIHAGYKPFVCEFCGKGFHQKGNYKNHKLTH 360

  Fly   303 TGEKAFRCDLCDKLFSRYTHLTTHYRSNAHRRNMQKADT 341
            :|||.::|.:|:|.|.:..:||.|    .|..|.:|..|
Frog   361 SGEKQYKCTICNKAFHQIYNLTFH----MHTHNDKKPFT 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871	19/95 (20%)
		C2H2 Zn finger	198..218	CDD:275368	5/19 (26%)
		COG5048	222..>276	CDD:227381	21/53 (40%)
		C2H2 Zn finger	226..246	CDD:275368	6/19 (32%)
		zf-H2C2_2	238..262	CDD:290200	11/23 (48%)
		C2H2 Zn finger	254..274	CDD:275368	7/19 (37%)
		zf-H2C2_2	269..291	CDD:290200	9/21 (43%)
		C2H2 Zn finger	282..302	CDD:275368	7/19 (37%)
		zf-H2C2_2	295..319	CDD:290200	12/23 (52%)
		C2H2 Zn finger	310..328	CDD:275368	7/17 (41%)
fezf2	NP_001016305.1	Engrailed homology 1 repressor. /evidence=ECO:0000250	27..42
		COG5048	<239..401	CDD:227381	55/161 (34%)
		C2H2 Zn finger	256..276	CDD:275368	5/19 (26%)
		C2H2 Zn finger	284..304	CDD:275368	6/19 (32%)
		C2H2 Zn finger	312..332	CDD:275368	7/19 (37%)
		C2H2 Zn finger	340..360	CDD:275368	7/19 (37%)
		C2H2 Zn finger	368..388	CDD:275368	8/23 (35%)
		C2H2 Zn finger	396..414	CDD:275368	92/364 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	108	1.000	Inparanoid score	I4763
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050