DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and ZNF793

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_001013681.2	Gene:	ZNF793 / 390927	HGNCID:	33115	Length:	406	Species:	Homo sapiens

Alignment Length:	323	Identity:	93/323 - (28%)
Similarity:	133/323 - (41%)	Gaps:	57/323 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LNIFEKRNQTTLEHIKLLTGAVLKNCSTLPNRLCASCQ-----------TCLQQAISFRERCLEV 72
            :||..||.|..|    |..||.:.. .|||..  .||:           |.|..:|.........
Human    85 VNIQRKRRQDML----LRPGAAISK-KTLPKE--KSCEYNKFGKISLLSTDLFSSIQSPSNWNPC 142

  Fly    73 QRELLHSQDDEDFLRICQESPKSVLEQEELELDLAEISIEVERLDDLNEGPIQSSGFKVEDILNE 137
            .:.|.|:.|...|.|.|.:.........:|             |..:|.|
Human   143 GKNLNHNLDLIGFKRNCAKKQDECYAYGKL-------------LQRINHG--------------- 179

  Fly   138 SKINEDEPNNEDDIDYSEMDYLIYESDTEVDAKQELKSDSENPKKRRNRRNPRDSNRTFFCEECG 202
                 ..||.|.....|..:    ::.|:..|.....:.|::...:|.|..|  :.:...|.|||
Human   180 -----RRPNGEKPRGCSHCE----KAFTQNPALMYKPAVSDSLLYKRKRVPP--TEKPHVCSECG 233

  Fly   203 NHIKDRISFILHCKRHRGVKEFGCEFCEDRFCTPAELKRHIRKHTGEKPFKCRHCSRSFSDYSTR 267
            .....:..||.|.:.|.|.|.:||..|...|...:.|.:|.|.|||.:||:|..|.::|:..|.|
Human   234 KAFCYKSEFIRHQRSHTGEKPYGCTDCGKAFSHKSTLIKHQRIHTGVRPFECFFCGKAFTQKSHR 298

  Fly   268 LKHERTHTNERPFVCKECNNAFTTSYILKNHMLVHTGEKAFRCDLCDKLFSRYTHLTTHYRSN 330
            .:|:||||.||||||.||..:|.....|..|..:||||:.:||..|.|.||:.:.|..|:|::
Human   299 TEHQRTHTGERPFVCSECGKSFGEKSYLNVHRKMHTGERPYRCRECGKSFSQKSCLNKHWRTH 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871	17/68 (25%)
		C2H2 Zn finger	198..218	CDD:275368	7/19 (37%)
		COG5048	222..>276	CDD:227381	22/53 (42%)
		C2H2 Zn finger	226..246	CDD:275368	6/19 (32%)
		zf-H2C2_2	238..262	CDD:290200	10/23 (43%)
		C2H2 Zn finger	254..274	CDD:275368	7/19 (37%)
		zf-H2C2_2	269..291	CDD:290200	14/21 (67%)
		C2H2 Zn finger	282..302	CDD:275368	6/19 (32%)
		zf-H2C2_2	295..319	CDD:290200	11/23 (48%)
		C2H2 Zn finger	310..328	CDD:275368	7/17 (41%)
ZNF793	NP_001013681.2	KRAB	8..68	CDD:214630
		C2H2 Zn finger	190..221	CDD:275368	6/34 (18%)
		COG5048	<225..385	CDD:227381	56/137 (41%)
		C2H2 Zn finger	229..249	CDD:275368	7/19 (37%)
		C2H2 Zn finger	257..277	CDD:275368	6/19 (32%)
		C2H2 Zn finger	285..305	CDD:275368	7/19 (37%)
		C2H2 Zn finger	313..333	CDD:275368	6/19 (32%)
		C2H2 Zn finger	341..361	CDD:275368	8/19 (42%)
		C2H2 Zn finger	369..389	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910