DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and ZNF568

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_940941.2	Gene:	ZNF568 / 374900	HGNCID:	25392	Length:	644	Species:	Homo sapiens

Alignment Length:	360	Identity:	93/360 - (25%)
Similarity:	153/360 - (42%)	Gaps:	66/360 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CRTCGKRTNAERSLNIFEKRNQTTLEHIKLLTGAVLKNCSTLPNRLCA----------------- 53
            |:.|||..:          |.:..:.|.|:.||.....|:.     |.
Human   252 CKECGKAFS----------RKENLITHQKIHTGEKPYKCNE-----CGKAFIQMSNLIRHHRIHT 301

  Fly    54 -----SCQTCLQQAISFRERCLEVQRELLHSQDDEDFLRICQESPKSVLEQEELELDLAEISIEV 113
                 :|:.|.:   :|.::...::.|.:|:.:..   ..|:|..||..:::.|        ||.
Human   302 GEKPYACKDCWK---AFSQKSNLIEHERIHTGEKP---YECKECGKSFSQKQNL--------IEH 352

  Fly   114 ERLDDLNEGPIQSS----GF-KVEDILNESKINEDEPN---NEDDIDYSEMDYLIYESDTEVDAK 170
            |:: ...|.|...:    .| ::..:....:.:..|..   |:....:|:....|....:....|
Human   353 EKI-HTGEKPYACNECGRAFSRMSSVTLHMRSHTGEKPYKCNKCGKAFSQCSVFIIHMRSHTGEK 416

  Fly   171 QEL-----KSDSENPKKRRNRRNPRDSNRTFFCEECGNHIKDRISFILHCKRHRGVKEFGCEFCE 230
            ..:     |:.|::.....:.|| ..:.:.:.|:|||.....:.:.|.|.|.|.|.|.:.|..|.
Human   417 PYVCSECGKAFSQSSSLTVHMRN-HTAEKPYECKECGKAFSRKENLITHQKIHTGEKPYECSECG 480

  Fly   231 DRFCTPAELKRHIRKHTGEKPFKCRHCSRSFSDYSTRLKHERTHTNERPFVCKECNNAFTTSYIL 295
            ..|...:.|.||.|.||||||:.|..|.::||..|...:||:.||.|:|:.|.:|..||:....|
Human   481 KAFIQMSNLIRHQRIHTGEKPYACTVCGKAFSQKSNLTEHEKIHTGEKPYHCNQCGKAFSQRQNL 545

  Fly   296 KNHMLVHTGEKAFRCDLCDKLFSRYTHLTTHYRSN 330
            ..|..:|||||.|:|:.|.|.|||.:.||.|.||:
Human   546 LEHEKIHTGEKPFKCNECGKAFSRISSLTLHVRSH 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871	15/92 (16%)
		C2H2 Zn finger	198..218	CDD:275368	7/19 (37%)
		COG5048	222..>276	CDD:227381	22/53 (42%)
		C2H2 Zn finger	226..246	CDD:275368	7/19 (37%)
		zf-H2C2_2	238..262	CDD:290200	12/23 (52%)
		C2H2 Zn finger	254..274	CDD:275368	7/19 (37%)
		zf-H2C2_2	269..291	CDD:290200	10/21 (48%)
		C2H2 Zn finger	282..302	CDD:275368	6/19 (32%)
		zf-H2C2_2	295..319	CDD:290200	12/23 (52%)
		C2H2 Zn finger	310..328	CDD:275368	9/17 (53%)
ZNF568	NP_940941.2	KRAB	48..102	CDD:214630
		KRAB	48..87	CDD:279668
		C2H2 Zn finger	224..244	CDD:275368
		zf-H2C2_2	236..261	CDD:290200	4/18 (22%)
		COG5048	248..634	CDD:227381	93/360 (26%)
		C2H2 Zn finger	252..272	CDD:275368	7/29 (24%)
		zf-H2C2_2	264..289	CDD:290200	6/29 (21%)
		C2H2 Zn finger	280..300	CDD:275368	2/24 (8%)
		zf-H2C2_2	292..317	CDD:290200	3/27 (11%)
		C2H2 Zn finger	308..328	CDD:275368	4/22 (18%)
		zf-H2C2_2	320..345	CDD:290200	6/27 (22%)
		C2H2 Zn finger	336..356	CDD:275368	8/28 (29%)
		zf-H2C2_2	348..373	CDD:290200	7/33 (21%)
		C2H2 Zn finger	364..384	CDD:275368	1/19 (5%)
		zf-H2C2_2	380..401	CDD:290200	2/20 (10%)
		C2H2 Zn finger	392..412	CDD:275368	3/19 (16%)
		zf-H2C2_2	408..429	CDD:290200	2/20 (10%)
		C2H2 Zn finger	420..440	CDD:275368	4/20 (20%)
		zf-H2C2_2	432..457	CDD:290200	6/25 (24%)
		C2H2 Zn finger	448..468	CDD:275368	7/19 (37%)
		zf-H2C2_2	460..485	CDD:290200	9/24 (38%)
		C2H2 Zn finger	476..496	CDD:275368	7/19 (37%)
		zf-H2C2_2	488..513	CDD:290200	13/24 (54%)
		C2H2 Zn finger	504..524	CDD:275368	7/19 (37%)
		zf-H2C2_2	516..541	CDD:290200	10/24 (42%)
		C2H2 Zn finger	532..552	CDD:275368	6/19 (32%)
		zf-H2C2_2	544..569	CDD:290200	12/24 (50%)
		C2H2 Zn finger	560..580	CDD:275368	10/19 (53%)
		zf-H2C2_2	572..597	CDD:290200	5/9 (56%)
		C2H2 Zn finger	588..608	CDD:275368
		zf-H2C2_2	601..625	CDD:290200
		C2H2 Zn finger	616..636	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910