DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and ZNF677

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_001304927.1	Gene:	ZNF677 / 342926	HGNCID:	28730	Length:	584	Species:	Homo sapiens

Alignment Length:	331	Identity:	80/331 - (24%)
Similarity:	124/331 - (37%)	Gaps:	82/331 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CRTCGKRTNAERSLNIFEKRNQTTLEHIKLLTGAVLKNCSTLPNRLCASCQTCLQQA-ISFRERC 69
            |..|||..|...:|.          .|.::.||.....|:     :|.  :.|.|.: ::..:|
Human   293 CNECGKAFNQCSNLT----------RHQRVHTGEKPYQCN-----ICG--KVCSQNSNLASHQR- 339

  Fly    70 LEVQRELLHSQDDEDFLRICQESPKSVLEQEELELDLAEISIEVERLDDLNEGPIQSSGFKVEDI 134
                   :|:.:..   ..|.|..|:.:::..|.
Human   340 -------MHTGEKP---YKCNECGKAFIQRSHLW------------------------------- 363

  Fly   135 LNESKINEDEPNNEDDIDYSEMDYLIYESDTEVDAKQELKSDSENPKKRRNRRNPRDSNRTFFCE 199
                        ..:.|...|..|...|.|         |:.:|.....:::| .....:.:.|.
Human   364 ------------GHERIHTGEKPYKCNECD---------KAFAERSSLTQHKR-IHTGEKPYICN 406

  Fly   200 ECGNHIKDRISFILHCKRHRGVKEFGCEFCEDRFCTPAELKRHIRKHTGEKPFKCRHCSRSFSDY 264
            |||...|.......|...|.|.|...|..|...|...:.|..|.|.||||||:||..|.::|...
Human   407 ECGKAFKQCSHLTRHQNIHPGEKPHKCNVCGRAFIQSSSLVEHQRIHTGEKPYKCNKCDKAFIKR 471

  Fly   265 STRLKHERTHTNERPFVCKECNNAFTTSYILKNHMLVHTGEKAFRCDLCDKLFSRYTHLTTHYRS 329
            |....|:||||.|:|:.|.||..|||....|..|..:|||||.::|..|.|.|:::.:||.|.:.
Human   472 SHLWGHQRTHTGEKPYKCTECGKAFTERSNLTQHKKIHTGEKPYKCTECGKAFTQFANLTRHQKI 536

  Fly   330 NAHRRN 335
            :..:::
Human   537 HIEKKH 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871	14/71 (20%)
		C2H2 Zn finger	198..218	CDD:275368	6/19 (32%)
		COG5048	222..>276	CDD:227381	22/53 (42%)
		C2H2 Zn finger	226..246	CDD:275368	6/19 (32%)
		zf-H2C2_2	238..262	CDD:290200	12/23 (52%)
		C2H2 Zn finger	254..274	CDD:275368	6/19 (32%)
		zf-H2C2_2	269..291	CDD:290200	12/21 (57%)
		C2H2 Zn finger	282..302	CDD:275368	8/19 (42%)
		zf-H2C2_2	295..319	CDD:290200	11/23 (48%)
		C2H2 Zn finger	310..328	CDD:275368	7/17 (41%)
ZNF677	NP_001304927.1	KRAB	9..59	CDD:214630
		COG5048	194..540	CDD:227381	80/327 (24%)
		C2H2 Zn finger	265..285	CDD:275368
		C2H2 Zn finger	293..313	CDD:275368	7/29 (24%)
		C2H2 Zn finger	321..341	CDD:275368	5/34 (15%)
		C2H2 Zn finger	349..369	CDD:275368	4/62 (6%)
		C2H2 Zn finger	377..397	CDD:275368	5/29 (17%)
		C2H2 Zn finger	405..425	CDD:275368	6/19 (32%)
		C2H2 Zn finger	433..453	CDD:275368	6/19 (32%)
		C2H2 Zn finger	461..481	CDD:275368	6/19 (32%)
		C2H2 Zn finger	489..509	CDD:275368	8/19 (42%)
		C2H2 Zn finger	517..537	CDD:275368	7/19 (37%)
		C2H2 Zn finger	545..563	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910