DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and ZNF850

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_001180481.1	Gene:	ZNF850 / 342892	HGNCID:	27994	Length:	1090	Species:	Homo sapiens

Alignment Length:	403	Identity:	94/403 - (23%)
Similarity:	153/403 - (37%)	Gaps:	102/403 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CRTCGKRTNAERSLNIFEKRNQTTLEHIKLLTGAVLKNCS------TLPNRLCASCQ-------- 56
            |:.|||...:..:|          ::|.::.||....:|.      |:.:.|....|
Human   563 CKECGKSFTSRSAL----------IQHQRIHTGEKPYHCKECGKSFTVGSTLLQHQQIHTGEKPY 617

  Fly    57 TCLQQAISFRERCLEVQRELLHSQDDEDFLRICQESPKSVLEQEELELDLAEISIEVERL---DD 118
            .|.:...:||.|....|.:.:|:.:..   ..|||..|:.:....|        .:..|:   :.
Human   618 DCKECGKAFRLRLRLTQHQQIHTGEKP---YQCQECGKAFVSVSGL--------TQHHRIHTGEK 671

  Fly   119 LNEGPIQSSGFKVEDILNE-----------------------SKINEDEPNNEDDIDYSEMD--- 157
            ..|.|.....|:....||:                       |.:.:.:.|:.|:..|...:
Human   672 PYECPDCGKAFRQRTYLNQHRRIHTGEKPYECKECGKSFTFCSGLIQHQQNHTDEKPYDGKECGK 736

  Fly   158 -----------YLIYESDTEVDAKQELKSDSENPKKRRNRR------------------------ 187
                       ..|:..:...|.|:..||.:.:....::::
Human   737 SFTSHSTLIQHQQIHTGEKPYDCKECGKSFTSHSTLIQHQQIHTGEKLYDCKECGKSFTSHSTLI 801

  Fly   188 --NP-RDSNRTFFCEECGNHIKDRISFILHCKRHRGVKEFGCEFCEDRFCTPAELKRHIRKHTGE 249
              .| ....:.:.|:|||.....|.:.|.|...|.|.|.:.|:.|...|.:.:.|..|.|.||||
Human   802 QHQPLHTGEKPYHCKECGKSFTLRSALIQHRPVHTGEKRYSCKECGKSFTSRSTLIEHQRIHTGE 866

  Fly   250 KPFKCRHCSRSFSDYSTRLKHERTHTNERPFVCKECNNAFTTSYILKNHMLVHTGEKAFRCDLCD 314
            ||:.|:.|.:||:..|..::|.|.||.|:|:.||||..||.....|..|..:|||||.:||..|.
Human   867 KPYHCKECGKSFAFRSAIIQHRRIHTGEKPYDCKECGKAFRRRSKLTQHQRIHTGEKPYRCHECG 931

  Fly   315 KLFSRYTHLTTHY 327
            |.|.|::.||.|:
Human   932 KAFVRFSGLTKHH 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871	17/84 (20%)
		C2H2 Zn finger	198..218	CDD:275368	7/19 (37%)
		COG5048	222..>276	CDD:227381	21/53 (40%)
		C2H2 Zn finger	226..246	CDD:275368	6/19 (32%)
		zf-H2C2_2	238..262	CDD:290200	12/23 (52%)
		C2H2 Zn finger	254..274	CDD:275368	7/19 (37%)
		zf-H2C2_2	269..291	CDD:290200	12/21 (57%)
		C2H2 Zn finger	282..302	CDD:275368	8/19 (42%)
		zf-H2C2_2	295..319	CDD:290200	12/23 (52%)
		C2H2 Zn finger	310..328	CDD:275368	8/18 (44%)
ZNF850	NP_001180481.1	KRAB	7..67	CDD:214630
		KRAB	7..46	CDD:279668
		C2H2 Zn finger	199..219	CDD:275368
		C2H2 Zn finger	227..244	CDD:275368
		COG5048	243..659	CDD:227381	22/108 (20%)
		C2H2 Zn finger	255..275	CDD:275368
		C2H2 Zn finger	283..303	CDD:275368
		zf-H2C2_2	296..319	CDD:290200
		C2H2 Zn finger	311..331	CDD:275368
		zf-H2C2_2	324..348	CDD:290200
		C2H2 Zn finger	339..359	CDD:275368
		zf-H2C2_2	351..375	CDD:290200
		C2H2 Zn finger	367..387	CDD:275368
		zf-H2C2_2	379..403	CDD:290200
		C2H2 Zn finger	395..415	CDD:275368
		C2H2 Zn finger	423..443	CDD:275368
		zf-H2C2_2	436..460	CDD:290200
		C2H2 Zn finger	451..471	CDD:275368
		zf-H2C2_2	463..487	CDD:290200
		C2H2 Zn finger	479..499	CDD:275368
		zf-H2C2_2	493..516	CDD:290200
		C2H2 Zn finger	507..527	CDD:275368
		zf-H2C2_2	519..543	CDD:290200
		COG5048	531..947	CDD:227381	94/403 (23%)
		C2H2 Zn finger	535..555	CDD:275368
		C2H2 Zn finger	563..583	CDD:275368	6/29 (21%)
		zf-H2C2_2	575..599	CDD:290200	5/33 (15%)
		C2H2 Zn finger	591..611	CDD:275368	4/19 (21%)
		C2H2 Zn finger	619..639	CDD:275368	5/19 (26%)
		zf-H2C2_2	632..656	CDD:290200	6/26 (23%)
		C2H2 Zn finger	647..667	CDD:275368	6/27 (22%)
		zf-H2C2_2	660..684	CDD:290200	5/31 (16%)
		C2H2 Zn finger	675..695	CDD:275368	4/19 (21%)
		zf-H2C2_2	687..711	CDD:290200	2/23 (9%)
		C2H2 Zn finger	703..723	CDD:275368	1/19 (5%)
		C2H2 Zn finger	732..751	CDD:275368	0/18 (0%)
		C2H2 Zn finger	759..779	CDD:275368	3/19 (16%)
		C2H2 Zn finger	787..807	CDD:275368	1/19 (5%)
		C2H2 Zn finger	815..835	CDD:275368	7/19 (37%)
		C2H2 Zn finger	843..863	CDD:275368	6/19 (32%)
		zf-H2C2_2	856..879	CDD:290200	12/22 (55%)
		C2H2 Zn finger	871..891	CDD:275368	7/19 (37%)
		C2H2 Zn finger	899..919	CDD:275368	8/19 (42%)
		zf-H2C2_2	912..936	CDD:290200	12/23 (52%)
		C2H2 Zn finger	927..947	CDD:275368	8/18 (44%)
		C2H2 Zn finger	955..975	CDD:275368
		zf-H2C2_2	967..992	CDD:290200
		C2H2 Zn finger	983..1003	CDD:275368
		zf-H2C2_2	995..1020	CDD:290200
		C2H2 Zn finger	1011..1031	CDD:275368
		zf-H2C2_2	1024..1046	CDD:290200
		C2H2 Zn finger	1039..1059	CDD:275368
		zf-H2C2_2	1052..1076	CDD:290200
		C2H2 Zn finger	1067..1087	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000