Protein Alignment ranshi and Plag1

DIOPT Version :10

• Sequence 1: NP_649824.1
• Gene: ranshi / 41041
• FlyBaseID: FBgn0037620
• Length: 346
• Species: Drosophila melanogaster
• Sequence 2: NP_001008317.1
• Gene: Plag1 / 297804
• RGDID: 1305286
• Length: 499
• Species: Rattus norvegicus
• Alignment Length: 239
• Identity: 54/239 - (22%)
• Similarity: 87/239 - (36%)
• Gaps: 73/239 - (30%)

  Fly   172 ELKSDSENP--KKRRNRRNPRDSNRTFFCEECGNHIKDRISFILHCKRHRGVKEFGC--EFCEDR 232
            |::...:.|  |::|....||   :.|.|:.|...........:|...|.|.:.:.|  :.|...
  Rat    11 EVRDTQKAPSGKRKRGESKPR---KNFPCQLCDKAFNSVEKLKVHSFSHTGERPYKCTHQDCTKA 72

  Fly   233 FCTPAELKRHIRKHTGEKPFKCRHCSRSF--------------------------SDYSTR---- 267
            |.:..:|:||:..|:.||..||.:|.:.|                          ..|:|:
  Rat    73 FVSKYKLQRHMATHSPEKTHKCNYCEKMFHRKDHLKNHLHTHDPNKETFKCEECGKSYNTKLGFK 137

  Fly   268 ----------------------------LKHERTH-------TNERPFVCKECNNAFTTSYILKN 297
                                        |:|.::|       ..|:...|:.|...|.|...::.
  Rat   138 RHLALHAATSGDLTCKVCLQTFESTGVLLEHLKSHAGKSSGGVKEKKHQCEHCERRFYTRKDVRR 202

  Fly   298 HMLVHTGEKAFRCDLCDKLFSRYTHLTTHYRSNAHRRNMQKADT 341
            ||:||||.|.|.|..|.:.|.|..|||.|.: .:|.:.:.|..|
  Rat   203 HMVVHTGRKDFLCQYCAQRFGRKDHLTRHMK-KSHNQELLKVKT 245

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..76	CDD:462262
		C2H2 Zn finger	198..218	CDD:275368	3/19 (16%)
		COG5048	222..>276	CDD:227381	18/120 (15%)
		C2H2 Zn finger	226..246	CDD:275368	6/21 (29%)
		zf-H2C2_2	238..262	CDD:463886	10/49 (20%)
		C2H2 Zn finger	254..274	CDD:275368	7/77 (9%)
		C2H2 Zn finger	282..302	CDD:275368	6/19 (32%)
		zf-H2C2_2	295..319	CDD:463886	11/23 (48%)
		C2H2 Zn finger	310..328	CDD:275368	8/17 (47%)
Plag1	NP_001008317.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33		6/24 (25%)
		Interaction with KPNA2. /evidence=ECO:0000250	2..84		18/75 (24%)
		Nuclear localization signal. /evidence=ECO:0000250	22..25		1/2 (50%)
		C2H2 Zn finger	36..56	CDD:275368	3/19 (16%)
		Decreased nuclear import with localization in the nucleus but also in the cytoplasm. /evidence=ECO:0000250	41..242		43/201 (21%)
		SFP1	<58..139	CDD:227516	16/80 (20%)
		C2H2 Zn finger	64..86	CDD:275368	6/21 (29%)
		zf-H2C2_2	79..101	CDD:463886	9/21 (43%)
		C2H2 Zn finger	94..114	CDD:275368	3/19 (16%)
		C2H2 Zn finger	123..143	CDD:275368	2/19 (11%)
		C2H2 Zn finger	152..172	CDD:275368	2/19 (11%)
		C2H2 Zn finger	187..207	CDD:275368	6/19 (32%)
		C2H2 Zn finger	215..233	CDD:275368	8/17 (47%)
		Activates transcription, Inhibition of nuclear import due to lack of NLS and KPNA2 interaction. /evidence=ECO:0000250	243..499		1/3 (33%)
		Repression domain, contains 3 sumoylation motifs and massively decrease transcription activity. /evidence=ECO:0000250	243..383		1/3 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	364..400
		Massively activates transcription. /evidence=ECO:0000250	384..499