DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and Zfp945

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_001103724.1	Gene:	Zfp945 / 240041	MGIID:	2445132	Length:	794	Species:	Mus musculus

Alignment Length:	419	Identity:	95/419 - (22%)
Similarity:	142/419 - (33%)	Gaps:	128/419 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CRTCGKRTNAERSLNIFEK------------------RNQTTLEHIKLLTGAVLKNCSTLPNRLC 52
            |:.|||..:....|.|.::                  :......|.|:.||.....||
Mouse   345 CKECGKSLSTSSGLKIHQRIHTGERPYKCGDCDKSFTQKSNLRMHQKIHTGENTYKCS------- 402

  Fly    53 ASCQTCLQQAISFRERCLEVQRELLHSQDDE-------------DFLRI------------CQES 92
             .|..|      |.:|||....:.:||.:..             .:||.            |.:.
Mouse   403 -ECDKC------FTQRCLLRTHQRIHSGEKPYKCSECGKAFAGGSYLRSHQRIHSEKKPYKCSDC 460

  Fly    93 PKSVLEQEELELD-------------------LAEISIEVERLDDLNEGPIQSS----GFKVEDI 134
            .||...::.|.:.                   ..:.|:.:.:.....|.|.:.|    .|..:|.
Mouse   461 DKSFHRKDHLRIHQRIHTGEKPYKCSECDKCFTQKGSVRIHQRIHTGEKPYKCSKCDKSFTKKDC 525

  Fly   135 LNESKINEDEPNNEDDIDYSEMDYLIYESDTEVDAKQELKSDSENPKKRRNRRNPRDSNRTFFCE 199
            |...:|          |...|..|...|.||..:.|..|          |..:......|.:.|.
Mouse   526 LKIHQI----------IHTGEEPYKCSECDTSFNRKDHL----------RTHQRFHTGERIYKCS 570

  Fly   200 ECGNHIKDRISFILHCKRHRGVKEFGCEFCEDRFCTPAELKRHIRKHTGEKP------------- 251
            ||......:|:..:|.|.|.|...:.|..|:..|.....|:.|.|.|.||||
Mouse   571 ECDESFTQKINLRIHQKIHTGDNSYKCSGCDKSFNRRNHLRTHERIHAGEKPYNCREFENSFIQT 635

  Fly   252 ---------------FKCRHCSRSFSDYSTRLKHERTHTNERPFVCKECNNAFTTSYILKNHMLV 301
                           :|||.|.:||:..|....|:|.|:.|:|:.|.||...||:...|:.|..:
Mouse   636 GSLRIHQRLHSRKKLYKCRECDKSFTSSSYVRIHQRIHSGEKPYKCSECGKCFTSGSYLRMHQRI 700

  Fly   302 HTGEKAFRCDLCDKLFSRYTHLTTHYRSN 330
            |||:|.::|..|||.|::...|..|.||:
Mouse   701 HTGDKPYKCSDCDKCFTQKCSLRIHQRSH 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871	18/88 (20%)
		C2H2 Zn finger	198..218	CDD:275368	6/19 (32%)
		COG5048	222..>276	CDD:227381	21/81 (26%)
		C2H2 Zn finger	226..246	CDD:275368	6/19 (32%)
		zf-H2C2_2	238..262	CDD:290200	13/51 (25%)
		C2H2 Zn finger	254..274	CDD:275368	8/19 (42%)
		zf-H2C2_2	269..291	CDD:290200	9/21 (43%)
		C2H2 Zn finger	282..302	CDD:275368	7/19 (37%)
		zf-H2C2_2	295..319	CDD:290200	11/23 (48%)
		C2H2 Zn finger	310..328	CDD:275368	7/17 (41%)
Zfp945	NP_001103724.1	KRAB	34..92	CDD:214630
		KRAB	34..73	CDD:279668
		C2H2 Zn finger	205..225	CDD:275368
		C2H2 Zn finger	233..253	CDD:275368
		C2H2 Zn finger	261..281	CDD:275368
		C2H2 Zn finger	289..309	CDD:275368
		COG5048	340..754	CDD:227381	95/419 (23%)
		C2H2 Zn finger	345..365	CDD:275368	6/19 (32%)
		zf-H2C2_2	358..382	CDD:290200	2/23 (9%)
		C2H2 Zn finger	373..393	CDD:275368	2/19 (11%)
		C2H2 Zn finger	401..421	CDD:275368	8/33 (24%)
		zf-H2C2_2	414..437	CDD:290200	2/22 (9%)
		C2H2 Zn finger	429..449	CDD:275368	2/19 (11%)
		C2H2 Zn finger	457..477	CDD:275368	4/19 (21%)
		zf-H2C2_2	469..494	CDD:290200	1/24 (4%)
		C2H2 Zn finger	485..505	CDD:275368	1/19 (5%)
		zf-H2C2_2	497..521	CDD:290200	4/23 (17%)
		C2H2 Zn finger	513..533	CDD:275368	5/29 (17%)
		C2H2 Zn finger	541..561	CDD:275368	6/29 (21%)
		C2H2 Zn finger	569..589	CDD:275368	6/19 (32%)
		C2H2 Zn finger	597..617	CDD:275368	6/19 (32%)
		C2H2 Zn finger	625..645	CDD:275368	0/19 (0%)
		C2H2 Zn finger	653..673	CDD:275368	8/19 (42%)
		C2H2 Zn finger	681..701	CDD:275368	7/19 (37%)
		zf-H2C2_2	693..718	CDD:290200	11/24 (46%)
		C2H2 Zn finger	709..729	CDD:275368	8/19 (42%)
		zf-H2C2_2	721..746	CDD:290200	4/9 (44%)
		C2H2 Zn finger	737..757	CDD:275368
		zf-H2C2_2	749..774	CDD:290200
		C2H2 Zn finger	765..785	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000