DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and ZNF281

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_001268222.1	Gene:	ZNF281 / 23528	HGNCID:	13075	Length:	895	Species:	Homo sapiens

Alignment Length:	196	Identity:	57/196 - (29%)
Similarity:	90/196 - (45%)	Gaps:	25/196 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 ILNESKINEDEPNNEDDIDYSEMDYLIYESDTEVDAKQELKSDSENPKKRRNRRNPRDSNRTFFC 198
            :|:.|...:|....|:.           :.||.|...:..|.:|:..|.   :|.|..|::.
Human   196 LLSSSSRTDDHHGTEEP-----------KQDTNVKKAKRPKPESQGIKA---KRKPSASSKP--- 243

  Fly   199 EECGNHIKDRISFILHCKRHRGVKEFGCEFCEDRFCTPAELKRHIRKHTGEKPFKCRHCSRSFSD 263
                :.:.|....||...:    |...|:.|...|.:...|:||:..||||:||:|..||..|..
Human   244 ----SLVGDGEGAILSPSQ----KPHICDHCSAAFRSSYHLRRHVLIHTGERPFQCSQCSMGFIQ 300

  Fly   264 YSTRLKHERTHTNERPFVCKECNNAFTTSYILKNHMLVHTGEKAFRCDLCDKLFSRYTHLTTHYR 328
            .....:||:.|:.|:||.|.:|:..|...|.::.|...|:|||.::||.|.:.|||...|..|.|
Human   301 KYLLQRHEKIHSREKPFGCDQCSMKFIQKYHMERHKRTHSGEKPYKCDTCQQYFSRTDRLLKHRR 365

  Fly   329 S 329
            :
Human   366 T 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871
		C2H2 Zn finger	198..218	CDD:275368	3/19 (16%)
		COG5048	222..>276	CDD:227381	20/53 (38%)
		C2H2 Zn finger	226..246	CDD:275368	6/19 (32%)
		zf-H2C2_2	238..262	CDD:290200	12/23 (52%)
		C2H2 Zn finger	254..274	CDD:275368	6/19 (32%)
		zf-H2C2_2	269..291	CDD:290200	9/21 (43%)
		C2H2 Zn finger	282..302	CDD:275368	5/19 (26%)
		zf-H2C2_2	295..319	CDD:290200	9/23 (39%)
		C2H2 Zn finger	310..328	CDD:275368	8/17 (47%)
ZNF281	NP_001268222.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..113
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	130..149
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	183..253		14/77 (18%)
		C2H2 Zn finger	263..283	CDD:275368	6/19 (32%)
		zf-H2C2_2	275..300	CDD:316026	13/24 (54%)
		C2H2 Zn finger	291..311	CDD:275368	6/19 (32%)
		zf-H2C2_2	304..328	CDD:316026	9/23 (39%)
		C2H2 Zn finger	319..339	CDD:275368	5/19 (26%)
		zf-H2C2_2	331..356	CDD:316026	9/24 (38%)
		C2H2 Zn finger	347..366	CDD:275368	8/18 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..427
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	638..660
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	778..817
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910