DRSC/TRiP Functional Genomics Resources

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Protein Alignment ranshi and ZNF449

DIOPT Version :9

Sequence 1:NP_649824.1 Gene:ranshi / 41041 FlyBaseID:FBgn0037620 Length:346 Species:Drosophila melanogaster
Sequence 2:NP_689908.3 Gene:ZNF449 / 203523 HGNCID:21039 Length:518 Species:Homo sapiens


Alignment Length:422 Identity:97/422 - (22%)
Similarity:149/422 - (35%) Gaps:145/422 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 NRLCASCQTCLQQAISFRERCLEVQRELLHSQDDEDFLRI------------CQESPKSVLE--- 98
            |:|...|...|:..:..:|:.||:.  :|     |.||.|            |.|:.:.|:.   
Human    49 NKLWELCCQWLKPKMRSKEQILELL--VL-----EQFLTILPTEIETWVREHCPENRERVVSLIE 106

  Fly    99 --QEELELDLAEISIEVERLDDL-------------------------NEGPIQSS--------- 127
              |.|||:...::.:....|::|                         .|.|:..:         
Human   107 DLQRELEIPEQQVDMHDMLLEELAPVGTAHIPPTMHLESPALQVMGPAQEAPVAEAWIPQAGPPE 171

  Fly   128 ---------------GFKVEDI-LNESKINEDEP--------------------------NNEDD 150
                           |:.:..: :|.|..|.:||                          |.||.
Human   172 LNYGATGECQNFLDPGYPLPKLDMNFSLENREEPWVKELQDSKEMKQLLDSKIGFEIGIENEEDT 236

  Fly   151 IDYSEM----------------------DYLIYESDTEV---DAKQELKS--DSENP-------- 180
            ....:|                      ||:..|:..|.   |.:.:|..  |.:||        
Human   237 SKQKKMETMYPFIVTLEGNALQGPILQKDYVQLENQWETPPEDLQTDLAKLVDQQNPTLGETPEN 301

  Fly   181 --------KKRRNRRNPRDSNRTFFCEECGNHIKDRISFILHCKRHRGVKEFGCEFCEDRFCTPA 237
                    .|...:::|  ..:...|.:||.....:.....|.:.|.|.:...|..|..||...:
Human   302 SNLEEPLNPKPHKKKSP--GEKPHRCPQCGKCFARKSQLTGHQRIHSGEEPHKCPECGKRFLRSS 364

  Fly   238 ELKRHIRKHTGEKPFKCRHCSRSFSDYSTRLKHERTHTNERPFVCKECNNAFTTSYILKNHMLVH 302
            :|.||.|.||||:|::|..|.:.|:..|..:.|:|||:.|..:.|.||..:|.....||.|:..|
Human   365 DLYRHQRLHTGERPYECTVCKKRFTRRSHLIGHQRTHSEEETYKCLECGKSFCHGSSLKRHLKTH 429

  Fly   303 TGEKAFRCDLCDKLFSRYTHLTTHYRSNAHRR 334
            ||||..||..|.|.|||.|.||.|.|::...|
Human   430 TGEKPHRCHNCGKSFSRLTALTLHQRTHTEER 461

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ranshiNP_649824.1 zf-AD 5..77 CDD:214871 7/27 (26%)
C2H2 Zn finger 198..218 CDD:275368 4/19 (21%)
COG5048 222..>276 CDD:227381 21/53 (40%)
C2H2 Zn finger 226..246 CDD:275368 8/19 (42%)
zf-H2C2_2 238..262 CDD:290200 11/23 (48%)
C2H2 Zn finger 254..274 CDD:275368 6/19 (32%)
zf-H2C2_2 269..291 CDD:290200 9/21 (43%)
C2H2 Zn finger 282..302 CDD:275368 7/19 (37%)
zf-H2C2_2 295..319 CDD:290200 13/23 (57%)
C2H2 Zn finger 310..328 CDD:275368 10/17 (59%)
ZNF449NP_689908.3 SCAN 27..134 CDD:322011 21/91 (23%)
SFP1 <235..402 CDD:227516 39/168 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 292..325 4/34 (12%)
COG5048 <321..483 CDD:227381 53/141 (38%)
C2H2 Zn finger 325..345 CDD:275368 4/19 (21%)
C2H2 Zn finger 353..373 CDD:275368 8/19 (42%)
C2H2 Zn finger 381..401 CDD:275368 6/19 (32%)
C2H2 Zn finger 409..429 CDD:275368 7/19 (37%)
C2H2 Zn finger 437..457 CDD:275368 11/19 (58%)
C2H2 Zn finger 465..485 CDD:275368
zf-H2C2_2 477..502 CDD:316026
C2H2 Zn finger 493..513 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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