DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and ZNF675

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_612203.2	Gene:	ZNF675 / 171392	HGNCID:	30768	Length:	568	Species:	Homo sapiens

Alignment Length:	343	Identity:	87/343 - (25%)
Similarity:	132/343 - (38%)	Gaps:	68/343 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CRTCGKRTNAERSLNIFEKRNQTTLEHIKLLTGAVLKNCSTLPNRLCASCQTCLQQAISFRERCL 70
            |..|||..|....|        ||  |..:.||       ..|.: |..|.....|..:.
Human   258 CEECGKAFNQSSHL--------TT--HKIIHTG-------EKPYK-CEECGKAFNQFSNL----- 299

  Fly    71 EVQRELLHSQDDEDFLRICQESPKSVLEQEELELDLAEISIEVERLDDLNEGPIQSSGFKVED-- 133
             ...:.:|:.:..   .||:|..|:..:..         ::...:.....|.|     :|.|:
Human   300 -TTHKKIHTGEQP---YICEECGKAFTQSS---------TLTTHKRIHTGEKP-----YKCEECG 346

  Fly   134 --ILNESKINEDEPNNEDDIDYSEMDYLIYESDTEVDAKQELKS-----DSENPKKRR------- 184
              ....||:.|.:     :|...|..|...|.....:....|..     ..|.|.|.:
Human   347 KAFNRSSKLTEHK-----NIHTGEQPYKCEECGKAFNRSSNLTEHRKIHTEEKPYKCKECGKAFK 406

  Fly   185 ------NRRNPRDSNRTFFCEECGNHIKDRISFILHCKRHRGVKEFGCEFCEDRFCTPAELKRHI 243
                  ..:......:.:.|||||...........|.|.|.|.|.:.||.|...|...::|..|.
Human   407 HSSALTTHKRIHTGEKPYKCEECGKAFNRSSKLTEHKKLHTGKKPYKCEECGKAFIQSSKLTEHK 471

  Fly   244 RKHTGEKPFKCRHCSRSFSDYSTRLKHERTHTNERPFVCKECNNAFTTSYILKNHMLVHTGEKAF 308
            :.|:||.|:||..|.::|...|:...|:|.||.|:|:.|:||..||:.|..|..|.::|||||.:
Human   472 KIHSGEIPYKCEECGKAFKHSSSLTTHKRIHTGEKPYKCEECGKAFSRSSKLTEHKIIHTGEKPY 536

  Fly   309 RCDLCDKLFSRYTHLTTH 326
            :|:.|||.|::..:||.|
Human   537 KCERCDKAFNQSANLTKH 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871	15/70 (21%)
		C2H2 Zn finger	198..218	CDD:275368	7/19 (37%)
		COG5048	222..>276	CDD:227381	19/53 (36%)
		C2H2 Zn finger	226..246	CDD:275368	6/19 (32%)
		zf-H2C2_2	238..262	CDD:290200	9/23 (39%)
		C2H2 Zn finger	254..274	CDD:275368	6/19 (32%)
		zf-H2C2_2	269..291	CDD:290200	11/21 (52%)
		C2H2 Zn finger	282..302	CDD:275368	8/19 (42%)
		zf-H2C2_2	295..319	CDD:290200	12/23 (52%)
		C2H2 Zn finger	310..328	CDD:275368	8/17 (47%)
ZNF675	NP_612203.2	KRAB	4..62	CDD:214630
		KRAB	4..43	CDD:279668
		COG5048	169..556	CDD:227381	87/343 (25%)
		C2H2 Zn finger	174..194	CDD:275370
		C2H2 Zn finger	202..222	CDD:275368
		C2H2 Zn finger	230..250	CDD:275368
		C2H2 Zn finger	258..278	CDD:275368	9/29 (31%)
		zf-H2C2_2	270..295	CDD:290200	9/42 (21%)
		C2H2 Zn finger	286..306	CDD:275368	3/25 (12%)
		C2H2 Zn finger	314..334	CDD:275368	3/28 (11%)
		zf-H2C2_2	327..351	CDD:290200	4/28 (14%)
		C2H2 Zn finger	342..362	CDD:275368	4/24 (17%)
		C2H2 Zn finger	370..390	CDD:275368	2/19 (11%)
		zf-H2C2_2	382..407	CDD:290200	4/24 (17%)
		C2H2 Zn finger	398..418	CDD:275368	0/19 (0%)
		zf-H2C2_2	410..435	CDD:290200	5/24 (21%)
		C2H2 Zn finger	426..446	CDD:275368	7/19 (37%)
		C2H2 Zn finger	454..474	CDD:275368	6/19 (32%)
		C2H2 Zn finger	482..502	CDD:275368	6/19 (32%)
		zf-H2C2_2	494..519	CDD:290200	11/24 (46%)
		C2H2 Zn finger	510..530	CDD:275368	8/19 (42%)
		C2H2 Zn finger	538..558	CDD:275368	8/17 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910