DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and ZNF721

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_597731.2	Gene:	ZNF721 / 170960	HGNCID:	29425	Length:	923	Species:	Homo sapiens

Alignment Length:	343	Identity:	88/343 - (25%)
Similarity:	134/343 - (39%)	Gaps:	68/343 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CRTCGKRTNAERSLNIFEKRNQTTLEHIKLLTGAVLKNCSTLPNRLCASCQTCLQQAISFRERCL 70
            |..|||.......||          :|.|:.||..|           ..|:.|.:..:.:.:  |
Human   587 CEECGKAFGRYTDLN----------QHKKIHTGEKL-----------YKCEECGKDFVWYTD--L 628

  Fly    71 EVQRELLHSQDDEDFLRICQESPKSVLEQEEL----ELDLAEISIEVERLDDLNEGPIQSSGFKV 131
            ..|:::...:....    |:|..|:.....:|    ::...|.|.:.|...       ::.|:.:
Human   629 NQQKKIYTGEKPYK----CEECGKAFAPSTDLNQHTKILTGEQSYKCEECG-------KAFGWSI 682

  Fly   132 EDILNESKINEDEPNNEDDIDYSEMDYLIYESDTEVDAKQELKS-----DSENPKKRRNR----- 186
              .||:.|          .|...|..|...|........:.|.:     ..|.|.|..:|
Human   683 --ALNQHK----------KIHTGEKPYKCEECGKAFSRSRNLTTHRRVHTREKPYKCEDRGRSFG 735

  Fly   187 --------RNPRDSNRTFFCEECGNHIKDRISFILHCKRHRGVKEFGCEFCEDRFCTPAELKRHI 243
                    :.....::.:.|:|||...|.......|.|.|.|.|.:.|:.|.....:.:...:|.
Human   736 WSTNLNEYKKIHTGDKLYKCKECGKVFKQSSHLNRHEKIHTGKKPYKCKECGKVITSSSSFAKHK 800

  Fly   244 RKHTGEKPFKCRHCSRSFSDYSTRLKHERTHTNERPFVCKECNNAFTTSYILKNHMLVHTGEKAF 308
            |.|||||||||..|.::|:..:|..||.|.||.|:|:.|:||..||..|.||..|..:|||||.:
Human   801 RIHTGEKPFKCLECGKAFTSSTTLTKHRRIHTGEKPYTCEECGKAFRQSAILYVHRRIHTGEKPY 865

  Fly   309 RCDLCDKLFSRYTHLTTH 326
            .|..|.|.|.:..:|..|
Human   866 TCGECGKTFRQSANLYAH 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871	15/70 (21%)
		C2H2 Zn finger	198..218	CDD:275368	7/19 (37%)
		COG5048	222..>276	CDD:227381	21/53 (40%)
		C2H2 Zn finger	226..246	CDD:275368	4/19 (21%)
		zf-H2C2_2	238..262	CDD:290200	12/23 (52%)
		C2H2 Zn finger	254..274	CDD:275368	7/19 (37%)
		zf-H2C2_2	269..291	CDD:290200	12/21 (57%)
		C2H2 Zn finger	282..302	CDD:275368	9/19 (47%)
		zf-H2C2_2	295..319	CDD:290200	11/23 (48%)
		C2H2 Zn finger	310..328	CDD:275368	6/17 (35%)
ZNF721	NP_597731.2	C2H2 Zn finger	83..103	CDD:275368
		COG5048	93..492	CDD:227381
		C2H2 Zn finger	111..131	CDD:275368
		C2H2 Zn finger	139..159	CDD:275368
		zf-H2C2_2	151..176	CDD:290200
		C2H2 Zn finger	167..187	CDD:275368
		C2H2 Zn finger	223..243	CDD:275368
		zf-H2C2_2	235..257	CDD:290200
		C2H2 Zn finger	251..271	CDD:275368
		C2H2 Zn finger	279..299	CDD:275368
		zf-H2C2_2	292..316	CDD:290200
		C2H2 Zn finger	307..327	CDD:275368
		zf-H2C2_2	319..344	CDD:290200
		C2H2 Zn finger	335..355	CDD:275368
		zf-H2C2_2	347..372	CDD:290200
		C2H2 Zn finger	363..383	CDD:275368
		zf-H2C2_2	375..400	CDD:290200
		C2H2 Zn finger	391..411	CDD:275368
		COG5048	442..885	CDD:227381	88/343 (26%)
		C2H2 Zn finger	447..467	CDD:275368
		C2H2 Zn finger	475..495	CDD:275368
		zf-H2C2_2	487..512	CDD:290200
		C2H2 Zn finger	503..523	CDD:275368
		zf-H2C2_2	516..540	CDD:290200
		C2H2 Zn finger	531..551	CDD:275368
		zf-H2C2_2	544..568	CDD:290200
		C2H2 Zn finger	559..579	CDD:275368
		zf-H2C2_2	571..596	CDD:290200	4/8 (50%)
		C2H2 Zn finger	587..607	CDD:275368	8/29 (28%)
		C2H2 Zn finger	615..634	CDD:275368	4/20 (20%)
		C2H2 Zn finger	643..663	CDD:275368	4/19 (21%)
		C2H2 Zn finger	671..691	CDD:275368	5/38 (13%)
		zf-H2C2_2	683..708	CDD:290200	7/34 (21%)
		C2H2 Zn finger	699..719	CDD:275368	2/19 (11%)
		C2H2 Zn finger	755..775	CDD:275368	7/19 (37%)
		zf-H2C2_2	767..789	CDD:290200	7/21 (33%)
		C2H2 Zn finger	783..803	CDD:275368	4/19 (21%)
		zf-H2C2_2	795..820	CDD:290200	13/24 (54%)
		C2H2 Zn finger	811..831	CDD:275368	7/19 (37%)
		zf-H2C2_2	824..848	CDD:290200	12/23 (52%)
		C2H2 Zn finger	839..859	CDD:275368	9/19 (47%)
		zf-H2C2_2	852..876	CDD:290200	11/23 (48%)
		C2H2 Zn finger	867..887	CDD:275368	6/17 (35%)
		C2H2 Zn finger	895..915	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000