DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and ZNF433

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	XP_011526027.1	Gene:	ZNF433 / 163059	HGNCID:	20811	Length:	684	Species:	Homo sapiens

Alignment Length:	154	Identity:	56/154 - (36%)
Similarity:	80/154 - (51%)	Gaps:	2/154 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 PKKRRNRRNPRDSNRTFFCEECGNHIKDRISFILHCKRHRGVKEFGCEFCEDRFCTPAELKRHIR 244
            |...|.........:.:.|:.||..:....||..|...|.|.....|:.|...|.:|:.|:.|.:
Human   333 PSSVRRHERTHSRKKPYECKHCGKVLSYLTSFQNHLGMHTGEISHKCKICGKAFYSPSSLQTHEK 397

  Fly   245 KHTGEKPFKCRHCSRSFSDYSTRLKHERTHTNERPFVCKECNNAFTTSYILKNHMLVHTGEKAFR 309
            .||||||:||..|.::|:..|:...||||||.|:|:.||:|..||.::.:|:.|...|||||.:.
Human   398 THTGEKPYKCNQCGKAFNSSSSFRYHERTHTGEKPYECKQCGKAFRSASLLQTHGRTHTGEKPYA 462

  Fly   310 CDLCDKLFSRYTHLTTHYRSNAHR 333
            |..|.|.||.::....|.|  .||
Human   463 CKECGKPFSNFSFFQIHER--MHR 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871
		C2H2 Zn finger	198..218	CDD:275368	6/19 (32%)
		COG5048	222..>276	CDD:227381	22/53 (42%)
		C2H2 Zn finger	226..246	CDD:275368	6/19 (32%)
		zf-H2C2_2	238..262	CDD:290200	11/23 (48%)
		C2H2 Zn finger	254..274	CDD:275368	7/19 (37%)
		zf-H2C2_2	269..291	CDD:290200	13/21 (62%)
		C2H2 Zn finger	282..302	CDD:275368	7/19 (37%)
		zf-H2C2_2	295..319	CDD:290200	11/23 (48%)
		C2H2 Zn finger	310..328	CDD:275368	6/17 (35%)
ZNF433	XP_011526027.1	KRAB	18..>60	CDD:214630
		KRAB	18..57	CDD:279668
		C2H2 Zn finger	145..175	CDD:275368
		C2H2 Zn finger	183..203	CDD:275368
		COG5048	208..614	CDD:227381	56/154 (36%)
		C2H2 Zn finger	211..231	CDD:275368
		zf-H2C2_2	227..248	CDD:290200
		C2H2 Zn finger	239..259	CDD:275368
		zf-H2C2_2	251..276	CDD:290200
		C2H2 Zn finger	267..287	CDD:275368
		zf-H2C2_2	283..304	CDD:290200
		C2H2 Zn finger	295..315	CDD:275368
		zf-H2C2_2	307..332	CDD:290200
		C2H2 Zn finger	323..343	CDD:275368	2/9 (22%)
		C2H2 Zn finger	351..371	CDD:275368	6/19 (32%)
		C2H2 Zn finger	379..399	CDD:275368	6/19 (32%)
		zf-H2C2_2	391..416	CDD:290200	12/24 (50%)
		C2H2 Zn finger	407..427	CDD:275368	7/19 (37%)
		zf-H2C2_2	419..444	CDD:290200	13/24 (54%)
		C2H2 Zn finger	435..455	CDD:275368	7/19 (37%)
		C2H2 Zn finger	463..483	CDD:275368	7/21 (33%)
		C2H2 Zn finger	491..511	CDD:275368
		C2H2 Zn finger	519..539	CDD:275368
		C2H2 Zn finger	547..567	CDD:275368
		C2H2 Zn finger	575..595	CDD:275368
		C2H2 Zn finger	603..623	CDD:275368
		C2H2 Zn finger	631..651	CDD:275368
		zf-H2C2_2	643..668	CDD:290200
		C2H2 Zn finger	659..679	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	0.118	Domainoid score	I11437
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000