DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and ZNF709

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_689814.1	Gene:	ZNF709 / 163051	HGNCID:	20629	Length:	641	Species:	Homo sapiens

Alignment Length:	354	Identity:	93/354 - (26%)
Similarity:	147/354 - (41%)	Gaps:	54/354 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CRTCGKRTNAERSLNIFEKRNQTTLEHIKLLTGAVLKNCSTLPNRLCASCQTCLQQAISFRERCL 70
            |:.|||.....::..|.|:.:          ||.....|......|  ||.|      |||
Human   254 CKQCGKAFRYYQTFQIHERTH----------TGEKPYQCKQCGKAL--SCPT------SFR---- 296

  Fly    71 EVQRELLHSQDDEDFLRICQES---PKSVLEQEEL----------ELDLAEISIEVER---LDDL 119
              ..|.:|:.:.....:.|.::   |.|..:.|.:          |...|.||:...|   :...
Human   297 --SHERIHTGEKPYKCKKCGKAFSFPSSFRKHERIHTGEKPYDCKECGKAFISLPSYRRHMIMHT 359

  Fly   120 NEGPIQSSGF-KVEDILNESKINEDEPNNEDDIDYSE------------MDYLIYESDTEVDAKQ 171
            ..||.:.... |..|..:..:|:|.....|...:..:            |....:..:...:.||
Human   360 GNGPYKCKECGKAFDCPSSFQIHERTHTGEKPYECKQCGKAFSCSSSFRMHERTHTGEKPHECKQ 424

  Fly   172 ELKSDSENPKKRRNRRNPRDSNRTFFCEECGNHIKDRISFILHCKRHRGVKEFGCEFCEDRFCTP 236
            ..|:.|.:...|.:.|. ....:.:.|::||.......||.:|.:.|.|.|.:.|:.|...|...
Human   425 CGKAFSCSSSVRIHERT-HTGEKPYECKQCGKAFSCSSSFRMHERIHTGEKPYECKQCGKAFSFS 488

  Fly   237 AELKRHIRKHTGEKPFKCRHCSRSFSDYSTRLKHERTHTNERPFVCKECNNAFTTSYILKNHMLV 301
            :..:.|.|.||||||::|:.|.::||..|:...||||||.|:|:.||:|..||:.|..::.|...
Human   489 SSFRMHERTHTGEKPYECKQCGKAFSCSSSFRMHERTHTGEKPYECKQCGKAFSCSSSIRIHERT 553

  Fly   302 HTGEKAFRCDLCDKLFSRYTHLTTHYRSN 330
            |||||.:.|..|.|.||..:.:..|.|::
Human   554 HTGEKPYECKQCGKAFSCSSSVRMHERTH 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871	17/70 (24%)
		C2H2 Zn finger	198..218	CDD:275368	6/19 (32%)
		COG5048	222..>276	CDD:227381	22/53 (42%)
		C2H2 Zn finger	226..246	CDD:275368	5/19 (26%)
		zf-H2C2_2	238..262	CDD:290200	10/23 (43%)
		C2H2 Zn finger	254..274	CDD:275368	8/19 (42%)
		zf-H2C2_2	269..291	CDD:290200	13/21 (62%)
		C2H2 Zn finger	282..302	CDD:275368	7/19 (37%)
		zf-H2C2_2	295..319	CDD:290200	10/23 (43%)
		C2H2 Zn finger	310..328	CDD:275368	6/17 (35%)
ZNF709	NP_689814.1	KRAB	3..44	CDD:396083
		COG5048	77..551	CDD:227381	80/321 (25%)
		C2H2 Zn finger	104..124	CDD:275368
		C2H2 Zn finger	142..162	CDD:275368
		C2H2 Zn finger	170..190	CDD:275368
		C2H2 Zn finger	198..218	CDD:275368
		C2H2 Zn finger	226..246	CDD:275368
		C2H2 Zn finger	254..274	CDD:275368	6/19 (32%)
		C2H2 Zn finger	282..302	CDD:275368	9/33 (27%)
		C2H2 Zn finger	310..330	CDD:275368	4/19 (21%)
		C2H2 Zn finger	338..358	CDD:275368	5/19 (26%)
		C2H2 Zn finger	366..386	CDD:275368	4/19 (21%)
		C2H2 Zn finger	394..414	CDD:275368	1/19 (5%)
		C2H2 Zn finger	422..442	CDD:275368	6/20 (30%)
		C2H2 Zn finger	450..470	CDD:275368	6/19 (32%)
		C2H2 Zn finger	478..498	CDD:275368	5/19 (26%)
		C2H2 Zn finger	506..526	CDD:275368	8/19 (42%)
		C2H2 Zn finger	534..554	CDD:275368	7/19 (37%)
		zf-H2C2_2	550..571	CDD:404364	10/20 (50%)
		C2H2 Zn finger	562..582	CDD:275368	7/19 (37%)
		zf-H2C2_2	574..599	CDD:404364	2/9 (22%)
		C2H2 Zn finger	590..610	CDD:275368
		C2H2 Zn finger	618..638	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	0.118	Domainoid score	I11437
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910