DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and ZNF480

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_653285.2	Gene:	ZNF480 / 147657	HGNCID:	23305	Length:	535	Species:	Homo sapiens

Alignment Length:	327	Identity:	93/327 - (28%)
Similarity:	124/327 - (37%)	Gaps:	64/327 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CRTCGKRTNAERSLNIFEKRNQTTLEHIKLLTGAVLKNCSTLPNRLCASCQTCLQQAISFRERCL 70
            |.:|||         :| .||....||.::.||.....|:........:......|.|..||:..
Human   233 CNSCGK---------VF-SRNSHLAEHCRIHTGEKPYKCNVCGKVFSYNSNFARHQRIHTREKPY 287

  Fly    71 EVQRELLHSQDDEDFLRICQE-----SPKSVLEQEELELDLAEISIEVERLDDLNEGPIQSSGFK 130
            |                 |.|     |..|.|.:.:      .|..| |:....||   ...||.
Human   288 E-----------------CNECGKVFSNNSYLARHQ------RIHAE-EKPYKCNE---CGKGFS 325

  Fly   131 VEDIL-NESKINEDEPNNEDDIDYSEMDYLIYESDTEVDAKQELKSDSENPKKRRNRRNPRDSNR 194
            .:..| |..:|...|...:.|    |.....|.....|  :.:.....|.|.|
Human   326 HKSSLANHWRIYTGEKPYKCD----ECGKAFYRIALLV--RHQKIHTGEKPYK------------ 372

  Fly   195 TFFCEECGNHIKDRISFILHCKRHRGVKEFGCEFCEDRFCTPAELKRHIRKHTGEKPFKCRHCSR 259
               |.|||...........|.:.|.|.|.:.|..|...|...:.|.||.|.||||||:||..|.:
Human   373 ---CNECGKVFIQNSHLAQHWRIHTGEKPYKCNECGKVFNQLSNLARHRRIHTGEKPYKCNECGK 434

  Fly   260 SFSDYSTRLKHERTHTNERPFVCKECNNAFTTSYILKNHMLVHTGEKAFRCDLCDKLFSRYTHLT 324
            :||:||....|...||.|:|:.|.||..||.....|.||..:||||:.::|:.|.|:|:|..||.
Human   435 AFSEYSGLSAHLVIHTGEKPYKCSECGKAFRHKLSLTNHQRIHTGERPYKCNECGKVFNRIAHLA 499

  Fly   325 TH 326
            .|
Human   500 RH 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871	17/70 (24%)
		C2H2 Zn finger	198..218	CDD:275368	5/19 (26%)
		COG5048	222..>276	CDD:227381	23/53 (43%)
		C2H2 Zn finger	226..246	CDD:275368	7/19 (37%)
		zf-H2C2_2	238..262	CDD:290200	13/23 (57%)
		C2H2 Zn finger	254..274	CDD:275368	7/19 (37%)
		zf-H2C2_2	269..291	CDD:290200	10/21 (48%)
		C2H2 Zn finger	282..302	CDD:275368	8/19 (42%)
		zf-H2C2_2	295..319	CDD:290200	11/23 (48%)
		C2H2 Zn finger	310..328	CDD:275368	8/17 (47%)
ZNF480	NP_653285.2	KRAB	27..87	CDD:214630
		KRAB	27..66	CDD:279668
		COG5048	<158..501	CDD:227381	92/325 (28%)
		C2H2 Zn finger	205..225	CDD:275368
		zf-H2C2_2	217..242	CDD:290200	5/18 (28%)
		C2H2 Zn finger	233..253	CDD:275368	9/29 (31%)
		zf-H2C2_2	245..270	CDD:290200	5/24 (21%)
		C2H2 Zn finger	261..281	CDD:275368	2/19 (11%)
		zf-H2C2_2	273..298	CDD:290200	7/41 (17%)
		C2H2 Zn finger	289..309	CDD:275368	5/25 (20%)
		zf-H2C2_2	301..326	CDD:290200	8/34 (24%)
		C2H2 Zn finger	317..336	CDD:275368	6/21 (29%)
		C2H2 Zn finger	345..365	CDD:275368	4/25 (16%)
		zf-H2C2_2	358..382	CDD:290200	8/40 (20%)
		C2H2 Zn finger	373..393	CDD:275368	5/19 (26%)
		zf-H2C2_2	385..410	CDD:290200	7/24 (29%)
		zf-C2H2	399..421	CDD:278523	7/21 (33%)
		C2H2 Zn finger	401..421	CDD:275368	7/19 (37%)
		zf-H2C2_2	413..437	CDD:290200	13/23 (57%)
		C2H2 Zn finger	429..449	CDD:275368	7/19 (37%)
		zf-H2C2_2	442..466	CDD:290200	10/23 (43%)
		C2H2 Zn finger	457..477	CDD:275368	8/19 (42%)
		zf-H2C2_2	469..494	CDD:290200	11/24 (46%)
		COG5048	481..>529	CDD:227381	8/21 (38%)
		C2H2 Zn finger	485..505	CDD:275368	8/17 (47%)
		zf-H2C2_2	497..522	CDD:290200	3/5 (60%)
		C2H2 Zn finger	513..533	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910