DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and ZNF664

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_001191227.1	Gene:	ZNF664 / 144348	HGNCID:	25406	Length:	261	Species:	Homo sapiens

Alignment Length:	294	Identity:	87/294 - (29%)
Similarity:	120/294 - (40%)	Gaps:	43/294 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 CQTCLQQAISFRERCLEVQRELLHSQDDEDFLRICQESPKSVLEQEELELDLAEISIE-VERLDD 118
            |..|.:   .|.||......:.:|:.:..   ..|.:..|......||.:...:.:.| |.:.||
Human     5 CPMCRE---FFSERADLFMHQKIHTAEKP---HKCDKCDKGFFHISELHIHWRDHTGEKVYKCDD 63

  Fly   119 LNEGPIQSSGFKVEDILNESKINEDEPNNEDDIDYSEMDYLIYESDTEVDAKQELK-----SDSE 178
            ..           :|....:|:|..:     .|...|..|..||.....:....|:     ...|
Human    64 CG-----------KDFSTTTKLNRHK-----KIHTVEKPYKCYECGKAFNWSSHLQIHMRVHTGE 112

  Fly   179 NPKKRRNRRNPRDSNRTFFCEECGNHIKDRISFILHCKRHRGVKEFGCEFCEDRFCTPAELKRHI 243
            .|               :.|.|||....:..:..:|.:.|.|.|.|.||.|...|...:.|..|.
Human   113 KP---------------YVCSECGRGFSNSSNLCMHQRVHTGEKPFKCEECGKAFRHTSSLCMHQ 162

  Fly   244 RKHTGEKPFKCRHCSRSFSDYSTRLKHERTHTNERPFVCKECNNAFTTSYILKNHMLVHTGEKAF 308
            |.||||||:||..|.::||..|:...|:|.||.|:|:.|..|..||:.|..|..|..||||||.|
Human   163 RVHTGEKPYKCYECGKAFSQSSSLCIHQRVHTGEKPYRCCGCGKAFSQSSSLCIHQRVHTGEKPF 227

  Fly   309 RCDLCDKLFSRYTHLTTHYRSNAHRRNMQKADTI 342
            :||.|.|.||:.|.|..|.|.:...||..|...|
Human   228 KCDECGKAFSQSTSLCIHQRVHTKERNHLKISVI 261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871	5/21 (24%)
		C2H2 Zn finger	198..218	CDD:275368	5/19 (26%)
		COG5048	222..>276	CDD:227381	24/53 (45%)
		C2H2 Zn finger	226..246	CDD:275368	7/19 (37%)
		zf-H2C2_2	238..262	CDD:290200	12/23 (52%)
		C2H2 Zn finger	254..274	CDD:275368	7/19 (37%)
		zf-H2C2_2	269..291	CDD:290200	10/21 (48%)
		C2H2 Zn finger	282..302	CDD:275368	7/19 (37%)
		zf-H2C2_2	295..319	CDD:290200	14/23 (61%)
		C2H2 Zn finger	310..328	CDD:275368	9/17 (53%)
ZNF664	NP_001191227.1	C2H2 Zn finger	5..25	CDD:275368	5/22 (23%)
		C2H2 Zn finger	33..53	CDD:275368	4/19 (21%)
		C2H2 Zn finger	61..81	CDD:275368	5/35 (14%)
		zf-H2C2_2	74..97	CDD:404364	6/27 (22%)
		C2H2 Zn finger	89..109	CDD:275368	3/19 (16%)
		COG5048	<94..256	CDD:227381	63/176 (36%)
		C2H2 Zn finger	117..137	CDD:275368	5/19 (26%)
		C2H2 Zn finger	145..165	CDD:275368	7/19 (37%)
		C2H2 Zn finger	173..193	CDD:275368	7/19 (37%)
		C2H2 Zn finger	201..221	CDD:275368	7/19 (37%)
		C2H2 Zn finger	229..249	CDD:275368	10/19 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910