DRSC/TRiP Functional Genomics Resources

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Protein Alignment ranshi and ZNF280B

DIOPT Version :9

Sequence 1:NP_649824.1 Gene:ranshi / 41041 FlyBaseID:FBgn0037620 Length:346 Species:Drosophila melanogaster
Sequence 2:NP_542942.2 Gene:ZNF280B / 140883 HGNCID:23022 Length:543 Species:Homo sapiens


Alignment Length:316 Identity:77/316 - (24%)
Similarity:119/316 - (37%) Gaps:94/316 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    91 ESPKSVLEQEELELDLAEISIEVERL---DDLNEGPIQSSGFKVEDILNESKINEDEPNN----- 147
            |||:...:....|::    ||..:|.   |.:.||  .||.....|..:.....:..|:|     
Human   167 ESPRVSKQLSTFEVN----SINPKRAKLRDGIIEG--NSSASFPSDTFHTMNTQQSTPSNNVHTS 225

  Fly   148 ---------------EDDIDYSEMDYLIYESDTEVDAKQEL-KSD-----SEN----PKKRRNRR 187
                           :|:|.:..:       :|.:|...|| |:|     |:|    |||    .
Human   226 LSHVQNGAPFPAAFPKDNIHFKPI-------NTNLDRANELAKTDILSLTSQNKTFDPKK----E 279

  Fly   188 NP-------------------RDSNRTFFCEECGNHIKDRISFILHCKRHRGVKEF--------- 224
            ||                   :.::.||.|..|...:|: :.|:.|.|.|   .||         
Human   280 NPIVLLSDFYYGQHKGEGQPEQKTHTTFKCLSCVKVLKN-VKFMNHVKHH---LEFEKQRNDSWE 340

  Fly   225 ---GCEFCEDRFCTPAELKRHIRK-HTGEKPFK-CRHCSRSFSDYSTRLKHERTH--TNERPFVC 282
               .|:.|..:|.||.:|:.||.. ||.::|.. |:.|..||......|:|.:.|  ..|.|:||
Human   341 NHTTCQHCHRQFPTPFQLQCHIENVHTAQEPSTVCKICELSFETDQVLLQHMKDHHKPGEMPYVC 405

  Fly   283 KECNNAFTTSYILKNHM-LVHTGEKAFRCDLCDKLFSRYTHLTTHYR----SNAHR 333
            :.|:...:....::.|. ..|...|...|..|.|:|...|....|||    .:||:
Human   406 QVCHYRSSVFADVETHFRTCHENTKNLLCPFCLKIFKTATPYMCHYRGHWGKSAHQ 461

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ranshiNP_649824.1 zf-AD 5..77 CDD:214871
C2H2 Zn finger 198..218 CDD:275368 6/19 (32%)
COG5048 222..>276 CDD:227381 20/69 (29%)
C2H2 Zn finger 226..246 CDD:275368 8/20 (40%)
zf-H2C2_2 238..262 CDD:290200 9/25 (36%)
C2H2 Zn finger 254..274 CDD:275368 6/19 (32%)
zf-H2C2_2 269..291 CDD:290200 7/23 (30%)
C2H2 Zn finger 282..302 CDD:275368 3/20 (15%)
zf-H2C2_2 295..319 CDD:290200 7/24 (29%)
C2H2 Zn finger 310..328 CDD:275368 6/17 (35%)
ZNF280BNP_542942.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
DUF4195 45..225 CDD:290548 15/63 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 105..138
C2H2 Zn finger 345..366 CDD:275368 8/20 (40%)
C2H2 Zn finger 375..395 CDD:275368 6/19 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 518..543
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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