DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and ZNF280A

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_542778.2	Gene:	ZNF280A / 129025	HGNCID:	18597	Length:	542	Species:	Homo sapiens

Alignment Length:	232	Identity:	59/232 - (25%)
Similarity:	96/232 - (41%)	Gaps:	28/232 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 FKVEDILNESKINEDEPN--NEDDIDYSEMDYLIYESDTEVDAKQE----LKSDSENPKKRRNRR 187
            |...|...::..|..:|.  :|..:..:::..|..::.| .|.|:|    |.||....:.:.:.:
Human   226 FPWPDANGKAHFNLTDPERASESALAMTDISSLASQNKT-FDPKKENPIVLLSDFYYGQHKGDGQ 289

  Fly   188 NPRDSNRTFFCEECGNHIKDRISFILHCKRHRGVKEF------------GCEFCEDRFCTPAELK 240
            ..:.::.||.|..|...:|: |.|:.|.|.|   .||            .|:.|..:|.||.:|:
Human   290 PEQKTHTTFKCLSCVKVLKN-IKFMNHMKHH---LEFEKQRNDSWEDHTTCQHCHRQFPTPFQLQ 350

  Fly   241 RHIRK-HTGEKPFK-CRHCSRSFSDYSTRLKHERTH--TNERPFVCKECNNAFTTSYILKNHM-L 300
            .||.. |....|.. |:.|..||......|:|.:.|  ..|.|:||:.|:...:....::.|. .
Human   351 CHIDSVHIAMGPSAVCKICELSFETDQVLLQHMKDHHKPGEMPYVCQVCHYRSSVFADVETHFRT 415

  Fly   301 VHTGEKAFRCDLCDKLFSRYTHLTTHYRSNAHRRNMQ 337
            .|...|...|..|.|||........|...::.||.:|
Human   416 CHENTKNLLCLFCLKLFKTAIPYMNHCWRHSRRRVLQ 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871
		C2H2 Zn finger	198..218	CDD:275368	7/19 (37%)
		COG5048	222..>276	CDD:227381	19/69 (28%)
		C2H2 Zn finger	226..246	CDD:275368	8/20 (40%)
		zf-H2C2_2	238..262	CDD:290200	8/25 (32%)
		C2H2 Zn finger	254..274	CDD:275368	6/19 (32%)
		zf-H2C2_2	269..291	CDD:290200	7/23 (30%)
		C2H2 Zn finger	282..302	CDD:275368	3/20 (15%)
		zf-H2C2_2	295..319	CDD:290200	8/24 (33%)
		C2H2 Zn finger	310..328	CDD:275368	6/17 (35%)
ZNF280A	NP_542778.2	DUF4195	47..217	CDD:316361
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	105..185
		C2H2 Zn finger	336..357	CDD:275368	8/20 (40%)
		C2H2 Zn finger	366..386	CDD:275368	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	502..542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7951
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860