DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ranshi and ZNF684

DIOPT Version :9

Sequence 1:NP_649824.1 Gene:ranshi / 41041 FlyBaseID:FBgn0037620 Length:346 Species:Drosophila melanogaster
Sequence 2:NP_689586.3 Gene:ZNF684 / 127396 HGNCID:28418 Length:378 Species:Homo sapiens


Alignment Length:260 Identity:79/260 - (30%)
Similarity:114/260 - (43%) Gaps:41/260 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    78 HSQDDEDFLRICQESPKSVLEQEELELDLAEISIEVERLDDLNE----GPIQSSGFK-VEDILNE 137
            |.:..::||       ||||      |...:| :.:||:...|.    .|::...:| .|..|  
Human    92 HRESKDNFL-------KSVL------LTFNKI-LTMERIHHYNMSTSLNPMRKKSYKSFEKCL-- 140

  Fly   138 SKINEDEPNNEDDIDYSEMDYLIYESDTEVDAKQELKSDSENPKKR----RNRRNPRDSNRTFFC 198
                  .||         :|.|.|.....|:...|.....:..||:    |:.:| ....:.|.|
Human   141 ------PPN---------LDLLKYNRSYTVENAYECSECGKAFKKKFHFIRHEKN-HTRKKPFEC 189

  Fly   199 EECGNHIKDRISFILHCKRHRGVKEFGCEFCEDRFCTPAELKRHIRKHTGEKPFKCRHCSRSFSD 263
            .:||.....:.....|.|.|.|.:.|.|..|...|...|:|..|.|.||||||::|..|.::|:.
Human   190 NDCGKAYSRKAHLATHQKIHNGERPFVCNDCGKAFMHKAQLVVHQRLHTGEKPYECSQCGKTFTW 254

  Fly   264 YSTRLKHERTHTNERPFVCKECNNAFTTSYILKNHMLVHTGEKAFRCDLCDKLFSRYTHLTTHYR 328
            .|:..:|.::||.|:.|.||||...|..|..|..|...|||||.::|.:|.|.|...:.|.||.|
Human   255 NSSFNQHVKSHTLEKSFECKECGKTFRYSSSLYKHSRFHTGEKPYQCIICGKAFGNTSVLVTHQR 319

  Fly   329  328
            Human   320  319

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ranshiNP_649824.1 zf-AD 5..77 CDD:214871
C2H2 Zn finger 198..218 CDD:275368 5/19 (26%)
COG5048 222..>276 CDD:227381 20/53 (38%)
C2H2 Zn finger 226..246 CDD:275368 7/19 (37%)
zf-H2C2_2 238..262 CDD:290200 11/23 (48%)
C2H2 Zn finger 254..274 CDD:275368 5/19 (26%)
zf-H2C2_2 269..291 CDD:290200 10/21 (48%)
C2H2 Zn finger 282..302 CDD:275368 8/19 (42%)
zf-H2C2_2 295..319 CDD:290200 11/23 (48%)
C2H2 Zn finger 310..328 CDD:275368 7/17 (41%)
ZNF684NP_689586.3 KRAB 8..68 CDD:214630
KRAB 8..47 CDD:279668
C2H2 Zn finger 161..181 CDD:275368 4/20 (20%)
zf-H2C2_2 173..198 CDD:290200 6/25 (24%)
COG5048 <185..345 CDD:227381 52/135 (39%)
zf-C2H2 187..209 CDD:278523 6/21 (29%)
C2H2 Zn finger 189..209 CDD:275368 5/19 (26%)
zf-H2C2_2 201..224 CDD:290200 7/22 (32%)
C2H2 Zn finger 217..237 CDD:275368 7/19 (37%)
zf-H2C2_2 230..253 CDD:290200 11/22 (50%)
C2H2 Zn finger 245..265 CDD:275368 5/19 (26%)
C2H2 Zn finger 273..293 CDD:275368 8/19 (42%)
zf-H2C2_2 285..308 CDD:290200 10/22 (45%)
C2H2 Zn finger 301..321 CDD:275368 8/19 (42%)
zf-H2C2_2 314..336 CDD:290200 4/6 (67%)
COG5048 325..>378 CDD:227381
C2H2 Zn finger 329..349 CDD:275368
zf-H2C2_2 341..366 CDD:290200
C2H2 Zn finger 357..377 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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