DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and ZNF440

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	XP_005259788.1	Gene:	ZNF440 / 126070	HGNCID:	20874	Length:	598	Species:	Homo sapiens

Alignment Length:	155	Identity:	55/155 - (35%)
Similarity:	83/155 - (53%)	Gaps:	0/155 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 PKKRRNRRNPRDSNRTFFCEECGNHIKDRISFILHCKRHRGVKEFGCEFCEDRFCTPAELKRHIR 244
            |:..|...........:.|::||..:....||..|.:.|.|.:.:.|:.|...||:....:||.:
Human   299 PRYVRIHERTHSRKNLYECKQCGKALSSLTSFQTHVRLHSGERPYECKICGKDFCSVNSFQRHEK 363

  Fly   245 KHTGEKPFKCRHCSRSFSDYSTRLKHERTHTNERPFVCKECNNAFTTSYILKNHMLVHTGEKAFR 309
            .|:||||:||:.|.::|...|:...||||||.|:|:.||:|..||.::..|:.|...|||||.:.
Human   364 IHSGEKPYKCKQCGKAFPHSSSLRYHERTHTGEKPYECKQCGKAFRSASHLRVHGRTHTGEKPYE 428

  Fly   310 CDLCDKLFSRYTHLTTHYRSNAHRR 334
            |..|.|.|....:|.:|.|:..|.|
Human   429 CKECGKAFRYVNNLQSHERTQTHIR 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871
		C2H2 Zn finger	198..218	CDD:275368	6/19 (32%)
		COG5048	222..>276	CDD:227381	21/53 (40%)
		C2H2 Zn finger	226..246	CDD:275368	6/19 (32%)
		zf-H2C2_2	238..262	CDD:290200	10/23 (43%)
		C2H2 Zn finger	254..274	CDD:275368	7/19 (37%)
		zf-H2C2_2	269..291	CDD:290200	13/21 (62%)
		C2H2 Zn finger	282..302	CDD:275368	7/19 (37%)
		zf-H2C2_2	295..319	CDD:290200	11/23 (48%)
		C2H2 Zn finger	310..328	CDD:275368	6/17 (35%)
ZNF440	XP_005259788.1	KRAB	7..>47	CDD:214630
		KRAB	7..46	CDD:279668
		C2H2 Zn finger	149..169	CDD:275368
		C2H2 Zn finger	177..197	CDD:275368
		zf-H2C2_2	189..214	CDD:290200
		COG5048	202..>492	CDD:227381	55/155 (35%)
		C2H2 Zn finger	205..225	CDD:275368
		zf-H2C2_2	221..242	CDD:290200
		C2H2 Zn finger	233..253	CDD:275368
		C2H2 Zn finger	261..281	CDD:275368
		zf-H2C2_2	273..298	CDD:290200
		C2H2 Zn finger	289..309	CDD:275368	2/9 (22%)
		C2H2 Zn finger	317..337	CDD:275368	6/19 (32%)
		C2H2 Zn finger	345..365	CDD:275368	6/19 (32%)
		zf-H2C2_2	357..380	CDD:290200	10/22 (45%)
		C2H2 Zn finger	373..393	CDD:275368	7/19 (37%)
		zf-H2C2_2	385..410	CDD:290200	13/24 (54%)
		C2H2 Zn finger	401..421	CDD:275368	7/19 (37%)
		zf-H2C2_2	413..438	CDD:290200	11/24 (46%)
		C2H2 Zn finger	429..448	CDD:275368	6/18 (33%)
		C2H2 Zn finger	463..483	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	0.118	Domainoid score	I11437
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000