DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and ZNF554

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_001096121.1	Gene:	ZNF554 / 115196	HGNCID:	26629	Length:	538	Species:	Homo sapiens

Alignment Length:	147	Identity:	59/147 - (40%)
Similarity:	83/147 - (56%)	Gaps:	0/147 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 RTFFCEECGNHIKDRISFILHCKRHRGVKEFGCEFCEDRFCTPAELKRHIRKHTGEKPFKCRHCS 258
            :.:.|.|||.......|...|.:.|.|.|.:.||.|...||..:.|..|.|.||||||::|..|.
Human   378 KPYGCGECGKAFNRISSLTQHQRIHTGEKPYKCEDCGKSFCQSSYLILHKRTHTGEKPYECSECG 442

  Fly   259 RSFSDYSTRLKHERTHTNERPFVCKECNNAFTTSYILKNHMLVHTGEKAFRCDLCDKLFSRYTHL 323
            ::|||.|:..:||||||.|.|:.||:|..||:....|..|...|||||.:||..|.|.||:.:.|
Human   443 KAFSDRSSLNQHERTHTGENPYECKQCGRAFSQRSSLVRHERTHTGEKPYRCQECGKAFSQSSSL 507

  Fly   324 TTHYRSNAHRRNMQKAD 340
            .||.::::.::..:..|
Human   508 VTHQKTHSSQKTYKIID 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871
		C2H2 Zn finger	198..218	CDD:275368	6/19 (32%)
		COG5048	222..>276	CDD:227381	26/53 (49%)
		C2H2 Zn finger	226..246	CDD:275368	8/19 (42%)
		zf-H2C2_2	238..262	CDD:290200	11/23 (48%)
		C2H2 Zn finger	254..274	CDD:275368	9/19 (47%)
		zf-H2C2_2	269..291	CDD:290200	13/21 (62%)
		C2H2 Zn finger	282..302	CDD:275368	7/19 (37%)
		zf-H2C2_2	295..319	CDD:290200	12/23 (52%)
		C2H2 Zn finger	310..328	CDD:275368	8/17 (47%)
ZNF554	NP_001096121.1	KRAB	44..84	CDD:307490
		COG5048	<225..417	CDD:227381	12/38 (32%)
		C2H2 Zn finger	276..291	CDD:275368
		C2H2 Zn finger	293..318	CDD:275368
		zf-C2H2	324..346	CDD:306579
		C2H2 Zn finger	326..346	CDD:275368
		COG5048	<350..532	CDD:227381	59/147 (40%)
		C2H2 Zn finger	354..374	CDD:275368
		C2H2 Zn finger	382..402	CDD:275368	6/19 (32%)
		C2H2 Zn finger	410..430	CDD:275368	8/19 (42%)
		C2H2 Zn finger	438..458	CDD:275368	9/19 (47%)
		C2H2 Zn finger	466..486	CDD:275368	7/19 (37%)
		C2H2 Zn finger	494..514	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910