DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and ZNF765-ZNF761

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_001337425.1	Gene:	ZNF765-ZNF761 / 110116772	-ID:	-	Length:	746	Species:	Homo sapiens

Alignment Length:	408	Identity:	103/408 - (25%)
Similarity:	154/408 - (37%)	Gaps:	110/408 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CRTCGKRTNAERSLNIFEKRNQTTLEHIKLLTGAVLKNCS------------TLPNRLCA----- 53
            |..|||         .|..::..|..| :|.||.....|:            |...||..
Human   356 CNECGK---------TFSHKSSLTCHH-RLHTGEKPYKCNECGKTFSHKSSLTCHRRLHTGEKPY 410

  Fly    54 SCQTCLQQAISFRERCLEVQRELLHSQDDEDFLRICQESPKSVLEQEELELDLAEISIEVERLDD 118
            .|:.| .:|.|||.. .|:.|: :|::|:   ...|.|..|:.....         |:...|...
Human   411 KCEEC-DKAYSFRSN-FEIHRK-IHTEDN---AYKCNECGKTFSRTS---------SLTCHRRRH 460

  Fly   119 LNEGPIQ----SSGFKVEDIL-NESKINEDEPN---NEDDIDYSEMDYL---------------- 159
            ..|.|.:    ...|:.:..| ...:|:..|..   ||....:|...||
Human   461 TGEQPYKCEECDKAFRFKSNLERHRRIHTGEKPYKCNECGKTFSRKSYLTCHHRLHTGEKAYKCN 525

  Fly   160 -----------------IYESDTEVDAKQELKSDSENPKKRRNRR-----NP---RDSNRTFF-- 197
                             ::..:.....|:..|:.::....:|:||     ||   .||::.:.
Human   526 ECGKTFSWKSSLTCHRRLHSGEKPYKCKECGKTFNQQLTLKRHRRLHSGENPYKCEDSDKAYSFK 590

  Fly   198 -----------------CEECGNHIKDRISFILHCKRHRGVKEFGCEFCEDRFCTPAELKRHIRK 245
                             |.|||.......|...|.:.|.|.|.:.||.|:..|...:.|:.|.|.
Human   591 SNLEIHQKIHTEENPYKCNECGKTFSRTSSLTCHRRLHTGEKPYKCEECDKAFRVKSNLEGHRRI 655

  Fly   246 HTGEKPFKCRHCSRSFSDYSTRLKHERTHTNERPFVCKECNNAFTTSYILKNHMLVHTGEKAFRC 310
            ||||||:||..|.::||..|..:.|.|.||.|:|:.|.||...|:....|..|..:|||||.::|
Human   656 HTGEKPYKCNECGKTFSRKSYFICHHRLHTGEKPYKCNECGKNFSQKSSLICHHRLHTGEKPYKC 720

  Fly   311 DLCDKLFSRYTHLTTHYR 328
            :.|.|.||:.::||.|.|
Human   721 NECGKTFSQKSNLTCHRR 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871	22/87 (25%)
		C2H2 Zn finger	198..218	CDD:275368	6/19 (32%)
		COG5048	222..>276	CDD:227381	23/53 (43%)
		C2H2 Zn finger	226..246	CDD:275368	7/19 (37%)
		zf-H2C2_2	238..262	CDD:290200	12/23 (52%)
		C2H2 Zn finger	254..274	CDD:275368	7/19 (37%)
		zf-H2C2_2	269..291	CDD:290200	10/21 (48%)
		C2H2 Zn finger	282..302	CDD:275368	6/19 (32%)
		zf-H2C2_2	295..319	CDD:290200	11/23 (48%)
		C2H2 Zn finger	310..328	CDD:275368	8/17 (47%)
ZNF765-ZNF761	NP_001337425.1	KRAB	7..48	CDD:307490
		C2H2 Zn finger	217..237	CDD:275368
		COG5048	242..617	CDD:227381	53/285 (19%)
		C2H2 Zn finger	244..264	CDD:275368
		C2H2 Zn finger	272..292	CDD:275368
		C2H2 Zn finger	300..320	CDD:275368
		C2H2 Zn finger	328..348	CDD:275368
		C2H2 Zn finger	356..376	CDD:275368	7/29 (24%)
		C2H2 Zn finger	384..404	CDD:275368	3/19 (16%)
		C2H2 Zn finger	412..432	CDD:275368	8/22 (36%)
		C2H2 Zn finger	440..460	CDD:275368	5/28 (18%)
		C2H2 Zn finger	468..488	CDD:275368	2/19 (11%)
		C2H2 Zn finger	496..516	CDD:275368	5/19 (26%)
		C2H2 Zn finger	524..544	CDD:275368	0/19 (0%)
		C2H2 Zn finger	552..572	CDD:275368	5/19 (26%)
		C2H2 Zn finger	580..600	CDD:275368	2/19 (11%)
		C2H2 Zn finger	608..628	CDD:275368	6/19 (32%)
		C2H2 Zn finger	636..656	CDD:275368	7/19 (37%)
		SFP1	<651..737	CDD:227516	38/85 (45%)
		C2H2 Zn finger	664..684	CDD:275368	7/19 (37%)
		C2H2 Zn finger	692..712	CDD:275368	6/19 (32%)
		C2H2 Zn finger	720..740	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000