DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and znf91

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	XP_004914096.2	Gene:	znf91 / 100488674	XenbaseID:	XB-GENE-990036	Length:	746	Species:	Xenopus tropicalis

Alignment Length:	462	Identity:	92/462 - (19%)
Similarity:	155/462 - (33%)	Gaps:	171/462 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VCRTCGKRTNAERSLNIFEKRNQTTLEHIKLLTGAVLKNCSTLPNRLCASCQTCLQQAISFR--E 67
            :|..|||         .|.:::..|: |:::.:|....:||        .|..|..||...|  |
Frog   318 ICAECGK---------TFVRKSDLTV-HLRIHSGERPYSCS--------YCGKCFCQASMLRRHE 364

  Fly    68 RCLEVQRELLHSQDDEDFLRICQESPKSVLEQEELELDLAEISIEVERLDDLNEGPIQ------- 125
            |....::....|:.|:.|.|                    ..|:.:.|:..:.:.|.:
Frog   365 RTHTGEKPYQCSECDKSFAR--------------------STSLLIHRIAHIKDKPFKCKSCAMT 409

  Fly   126 --------------SSGFKVE-DILNESKINEDEPNNEDDIDYSEMDYLIYES----DTEVDAKQ 171
                          .|..||. |:.|.|.......:.......||..:|..:.    ::::..::
Frog   410 FSNTTQLRQHTKTHRSSIKVPCDMCNNSCGQAHTCSLHGSGQLSEDPFLCSDCGRTFNSDLGLQR 474

  Fly   172 ELKSDSENP---------------KKRRNRRNPRDSNRTFFCEECGNHIKDRISFI-LHCKRHRG 220
            .|.:.::.|               .:...|.:|.|  |.|.|..||.:. .|::.: :|...|.|
Frog   475 HLLTHAQQPFPCKICGVVLNSRFDFRIHQRSHPPD--RPFICSHCGKNF-PRLNLLRIHQNTHTG 536

  Fly   221 VKEFGCEFCEDRFCTPAELKR-------------------------------------------- 241
            .:.:.|.||:..|..|:.|::
Frog   537 SRPYECSFCKKTFSDPSTLRQHRQRHQGVKPSLFKDKALPVNQESSNPTIKTHGCPSVCPECGKT 601

  Fly   242 ------------------------------------HIRKHTGEKPFKCRHCSRSFSDYSTRLKH 270
                                                |:|.||||:|:||.:|.:.|...|...:|
Frog   602 FSNPSALQKHQQSHEKESLLCAECGKNFSRKSDLTVHLRIHTGERPYKCSYCGKDFCQASMARRH 666

  Fly   271 ERTHTNERPFVCKECNNAFTTSYILKNHMLVHTGEKAFRCDLCDKLFSR----YTHLTTHYR--S 329
            |||||.|:|:.|.:|...|:.|..|..|...|...|.|:|..|::.||.    :.||.||..  :
Frog   667 ERTHTGEKPYQCSDCEKCFSRSSSLLIHRSKHIDAKPFKCVSCEQTFSNAGQLHVHLKTHEENVN 731

  Fly   330 NAHRRNM 336
            |..:.|:
Frog   732 NPLKNNL 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871	17/73 (23%)
		C2H2 Zn finger	198..218	CDD:275368	5/20 (25%)
		COG5048	222..>276	CDD:227381	23/133 (17%)
		C2H2 Zn finger	226..246	CDD:275368	8/99 (8%)
		zf-H2C2_2	238..262	CDD:290200	11/103 (11%)
		C2H2 Zn finger	254..274	CDD:275368	7/19 (37%)
		zf-H2C2_2	269..291	CDD:290200	11/21 (52%)
		C2H2 Zn finger	282..302	CDD:275368	6/19 (32%)
		zf-H2C2_2	295..319	CDD:290200	8/23 (35%)
		C2H2 Zn finger	310..328	CDD:275368	8/21 (38%)
znf91	XP_004914096.2	C2H2 Zn finger	79..99	CDD:275368
		COG5048	103..531	CDD:227381	44/253 (17%)
		C2H2 Zn finger	107..127	CDD:275368
		C2H2 Zn finger	135..155	CDD:275368
		C2H2 Zn finger	163..182	CDD:275368
		C2H2 Zn finger	189..209	CDD:275370
		C2H2 Zn finger	292..312	CDD:275368
		C2H2 Zn finger	319..339	CDD:275368	7/29 (24%)
		COG5048	343..730	CDD:227381	82/417 (20%)
		C2H2 Zn finger	347..367	CDD:275368	9/27 (33%)
		C2H2 Zn finger	375..395	CDD:275368	6/39 (15%)
		C2H2 Zn finger	403..423	CDD:275368	0/19 (0%)
		C2H2 Zn finger	459..479	CDD:275368	1/19 (5%)
		C2H2 Zn finger	486..506	CDD:275368	1/19 (5%)
		C2H2 Zn finger	514..534	CDD:275368	5/20 (25%)
		C2H2 Zn finger	542..562	CDD:275368	6/19 (32%)
		C2H2 Zn finger	595..615	CDD:275368	0/19 (0%)
		C2H2 Zn finger	622..642	CDD:275368	2/19 (11%)
		C2H2 Zn finger	650..670	CDD:275368	7/19 (37%)
		C2H2 Zn finger	678..698	CDD:275368	6/19 (32%)
		C2H2 Zn finger	706..726	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000724
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000