DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ranshi and Zfp945

DIOPT Version :9

Sequence 1:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	XP_006228161.2	Gene:	Zfp945 / 100362641	RGDID:	2324317	Length:	901	Species:	Rattus norvegicus

Alignment Length:	427	Identity:	96/427 - (22%)
Similarity:	144/427 - (33%)	Gaps:	144/427 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CRTCGKRTNAERSLNIFEKRNQTTLEHIKLLTGAVLKNCS------TLPNRL------------- 51
            |:.|||..:....|.|          |.::.||.....|:      |..:.|
  Rat   442 CKECGKTLSTSSGLKI----------HHRIHTGEKPYKCTECDKSFTQKSNLRMHQKIHTGENTF 496

  Fly    52 -CASCQTCLQQAISFRERCLEVQRELLHSQD--------DEDFL---------RI--------CQ 90
             |:.|..|      |.::||....:..||.:        |:.|.         ||        |.
  Rat   497 KCSDCNKC------FTQKCLLRIHQRTHSGEKPYKCNECDKAFAGSSYLRSHQRIHSGKKPYKCS 555

  Fly    91 ESPKSVLEQEELELD-------------------LAEISIEVERLDDLNEGPIQSS--------- 127
            |..||...::.|.:.                   ..:.|:.:.:.....|.|.:.|
  Rat   556 ECDKSFNRKDHLRIHQRVHTGEKPYKCSECDKCFTQKGSVRIHQRIHTGEKPYKCSKCDKSFTKK 620

  Fly   128 -GFKVEDILNESKINEDEPNNEDDIDYSEMDYLIYESDTEVDAKQELKSDSENPKKRRNRRNPRD 191
             |..:..|::..    :||            |...|.|...:.|..|          |..:....
  Rat   621 DGLVIHQIIHTG----EEP------------YKCSECDKSFNRKDHL----------RTHQRFHT 659

  Fly   192 SNRTFFCEECGNHIKDRISFILHCKRHRGVKEFGCEFCEDRFCTPAELKRHIRKHTGEKP----- 251
            ..|.:.|.||..:...:.|..:|.|.|.|.|.:.|..|...|.....|:.|.|.|.||||
  Rat   660 GERIYKCSECDEYFTQKSSLRIHQKIHTGDKTYKCSVCGKSFNRRNHLRTHERIHAGEKPYDCTE 724

  Fly   252 -----------------------FKCRHCSRSFSDYSTRLKHERTHTNERPFVCKECNNAFTTSY 293
                                   :||..|.:||:..|....|:|.|:.|:|:.|.|||..||:..
  Rat   725 FENSFTHNGSLRIHHRLHSRKKVYKCSECDKSFTSSSYVRIHQRIHSGEKPYKCSECNKCFTSGS 789

  Fly   294 ILKNHMLVHTGEKAFRCDLCDKLFSRYTHLTTHYRSN 330
            .|:.|..:|||:|.::|..|||.|::...|..|.||:
  Rat   790 YLRMHQRIHTGDKPYKCGECDKCFTQKCSLRIHQRSH 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871	18/90 (20%)
		C2H2 Zn finger	198..218	CDD:275368	6/19 (32%)
		COG5048	222..>276	CDD:227381	21/81 (26%)
		C2H2 Zn finger	226..246	CDD:275368	6/19 (32%)
		zf-H2C2_2	238..262	CDD:290200	12/51 (24%)
		C2H2 Zn finger	254..274	CDD:275368	7/19 (37%)
		zf-H2C2_2	269..291	CDD:290200	10/21 (48%)
		C2H2 Zn finger	282..302	CDD:275368	8/19 (42%)
		zf-H2C2_2	295..319	CDD:290200	11/23 (48%)
		C2H2 Zn finger	310..328	CDD:275368	7/17 (41%)
Zfp945	XP_006228161.2	KRAB	131..171	CDD:396083
		C2H2 Zn finger	302..322	CDD:275368
		C2H2 Zn finger	330..350	CDD:275368
		C2H2 Zn finger	358..378	CDD:275368
		C2H2 Zn finger	386..406	CDD:275368
		SUF4-like	<436..>458	CDD:411020	6/25 (24%)
		C2H2 Zn finger	442..462	CDD:275368	7/29 (24%)
		zf-H2C2_2	455..479	CDD:404364	6/33 (18%)
		C2H2 Zn finger	470..490	CDD:275368	3/19 (16%)
		C2H2 Zn finger	498..518	CDD:275368	6/25 (24%)
		COG5048	522..872	CDD:227381	76/331 (23%)
		C2H2 Zn finger	526..546	CDD:275368	3/19 (16%)
		C2H2 Zn finger	554..574	CDD:275368	5/19 (26%)
		C2H2 Zn finger	582..602	CDD:275368	1/19 (5%)
		C2H2 Zn finger	610..630	CDD:275368	3/19 (16%)
		C2H2 Zn finger	638..658	CDD:275368	5/29 (17%)
		C2H2 Zn finger	666..686	CDD:275368	6/19 (32%)
		C2H2 Zn finger	694..714	CDD:275368	6/19 (32%)
		C2H2 Zn finger	722..742	CDD:275368	0/19 (0%)
		C2H2 Zn finger	750..770	CDD:275368	7/19 (37%)
		C2H2 Zn finger	778..798	CDD:275368	8/19 (42%)
		C2H2 Zn finger	806..826	CDD:275368	8/19 (42%)
		C2H2 Zn finger	834..854	CDD:275368
		C2H2 Zn finger	862..882	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11351
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000