DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8159 and ZNF646

DIOPT Version :9

Sequence 1:	NP_649823.2	Gene:	CG8159 / 41040	FlyBaseID:	FBgn0037619	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_055514.3	Gene:	ZNF646 / 9726	HGNCID:	29004	Length:	1832	Species:	Homo sapiens

Alignment Length:	450	Identity:	93/450 - (20%)
Similarity:	148/450 - (32%)	Gaps:	137/450 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CRVCASSTDNSKSL----KLFNSGACKVLQQINLLTGVLLQCEPGLPDWMCETCQTDLKSAISFR 66
            |..|..:..:..||    |:..:|                       |::|..|.....:..::|
Human  1054 CNQCGKTYRHGGSLVNHRKIHQTG-----------------------DFLCPVCSRCYPNLAAYR 1095

  Fly    67 D------RCLRS-----------------------------QKIFEESLVRNEEDTFRSSVR--- 93
            :      ||..|                             |.:.||...:.|.:..:..::
Human  1096 NHLRNHPRCKGSEPQVGPIPEAAGSSELQVGPIPEGGSNKPQHMAEEGPGQAEVEKLQEELKVEP 1160

  Fly    94 --RSARSQRQRHEDTAPKTPASPLEVMIKLESLSNGDEEDDGIDHLDSCNEADMELAIKAMSSST 156
              ..||.:.:..|:|..|..    |:..:||:...|.:.:...:...||         :....|.
Human  1161 LEEVARVKEEVWEETTVKGE----EIEPRLETAEKGCQTEASSERPFSC---------EVCGRSY 1212

  Fly   157 EDDGTTSPVRLKRTRRRGLKKGGKGENRTKVTLPVFFCDQCGNNITGKSSFDRHLRKHSGIRPFQ 221
            :..|  |.:..:::.:.|                .|.|..|....:...|...|.|.|:..|.|:
Human  1213 KHAG--SLINHRQSHQTG----------------HFGCQACSKGFSNLMSLKNHRRIHADPRRFR 1259

  Fly   222 CELCPARFLSSGELKGHQVMH-------------TGDRKFQCRYCDRTYVNYSGRLRHERTHTND 273
            |..|...|....:|..||.:|             ..||.|:|..|.|||.:....|.|.|:|...
Human  1260 CSECGKAFRLRKQLASHQRVHMERRGGGGTRKATREDRPFRCGQCGRTYRHAGSLLNHRRSHETG 1324

  Fly   274 RPFICAQCGKSFTNSYILKNHMLIHTGER----------LFRCELCHRSFARPTHLKTHFRSNTH 328
            : :.|..|.|:::|...||:|..:|:..|          ..||.||.|||.....|:.|.|.  |
Human  1325 Q-YSCPTCPKTYSNRMALKDHQRLHSENRRRRAGRSRRTAVRCALCGRSFPGRGSLERHLRE--H 1386

  Fly   329 KHNLEKSMADAGGV--------QLSPSQSADQVKFVTEKEPEAEADAFTIEVPLPAEQEQ 380
            :....:.....||:        .|:.||..:......|..|..|..     ||.|.|:.|
Human  1387 EETEREPANGQGGLDGTAASEANLTGSQGLETQLGGAEPVPHLEDG-----VPRPGERSQ 1441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8159	NP_649823.2	zf-AD	5..78	CDD:214871	14/110 (13%)
		C2H2 Zn finger	194..214	CDD:275368	5/19 (26%)
		COG5048	<197..322	CDD:227381	43/147 (29%)
		zf-H2C2_2	206..231	CDD:290200	9/24 (38%)
		C2H2 Zn finger	222..242	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		zf-H2C2_2	265..287	CDD:290200	6/21 (29%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		zf-H2C2_2	291..315	CDD:290200	12/33 (36%)
		C2H2 Zn finger	306..328	CDD:275368	9/21 (43%)
ZNF646	NP_055514.3	C2H2 Zn finger	10..31	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..47
		C2H2 Zn finger	50..70	CDD:275368
		zf-C2H2	75..97	CDD:333835
		C2H2 Zn finger	77..97	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..200
		C2H2 Zn finger	241..261	CDD:275368
		C2H2 Zn finger	268..288	CDD:275368
		C2H2 Zn finger	296..316	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..346
		C2H2 Zn finger	376..396	CDD:275368
		C2H2 Zn finger	403..423	CDD:275368
		C2H2 Zn finger	467..487	CDD:275368
		C2H2 Zn finger	494..514	CDD:275368
		C2H2 Zn finger	577..597	CDD:275368
		C2H2 Zn finger	619..639	CDD:275368
		C2H2 Zn finger	646..663	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	660..810
		C2H2 Zn finger	823..843	CDD:275368
		C2H2 Zn finger	850..870	CDD:275368
		C2H2 Zn finger	883..901	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	901..931
		C2H2 Zn finger	1054..1074	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1081..1101	CDD:275368	3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1103..1148		6/44 (14%)
		C2H2 Zn finger	1205..1225	CDD:275368	4/30 (13%)
		C2H2 Zn finger	1232..1252	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1260..1280	CDD:275368	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1274..1294		3/19 (16%)
		C2H2 Zn finger	1301..1321	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1328..1348	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1366..1386	CDD:275368	9/21 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1377..1481		16/71 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1509..1529
		C2H2 Zn finger	1533..1552	CDD:275368
		C2H2 Zn finger	1559..1579	CDD:275368
		C2H2 Zn finger	1587..1611	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1606..1672
		C2H2 Zn finger	1679..1699	CDD:275368
		C2H2 Zn finger	1706..1726	CDD:275368
		zf-H2C2_2	1718..1743	CDD:372612
		C2H2 Zn finger	1734..1754	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1781..1832
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910