DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8159 and CRZ1

DIOPT Version :9

Sequence 1:	NP_649823.2	Gene:	CG8159 / 41040	FlyBaseID:	FBgn0037619	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_014371.1	Gene:	CRZ1 / 855704	SGDID:	S000004972	Length:	678	Species:	Saccharomyces cerevisiae

Alignment Length:	359	Identity:	82/359 - (22%)
Similarity:	137/359 - (38%)	Gaps:	96/359 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 DNSKSLKLFNSGACKVLQQINLLTGVLLQCEPGLPDWMCETCQTDLKSAISFRDRCLRSQKIFEE 78
            |.:..||:.::.:.......|||       .|...|:..|.. :|:..  ||.| .:..:|:..:
Yeast   350 DGTLQLKVRDNESYSATNNNNLL-------RPDDNDYNNEAL-SDIDR--SFED-IINGRKLKLK 403

  Fly    79 SLVRNEEDTFRSSV--RRSARSQRQRHEDTAPKTPASPLEVMIKLESLSNGDEEDDGIDHLDSCN 141
            ...|....|..:|.  |||:|| |....|...|:.::..|.::::..|....|.|:..:..|:
Yeast   404 KSRRRSSQTSNNSFTSRRSSRS-RSISPDEKAKSISANREKLLEMADLLPSSENDNNRERYDN-- 465

  Fly   142 EADMELAIKAMSSS--TEDDG-----TTSP------VRLKR---------------------TRR 172
              |.:.:...::||  .||:.     |:.|      |.:|.                     .::
Yeast   466 --DSKTSYNTINSSNFNEDNNNNNLLTSKPKIESGIVNIKNELDDTSKDLGILLDIDSLGQFEQK 528

  Fly   173 RGLKKGGKGENRTKVTLPVFFCDQCGNNITGKSSFDRHLRKHSGIRPFQCELCPARFLSSGELKG 237
            .|.|.....||....|..|    :..:|:....|...:.:..:.   |.|::|..:|.....||.
Yeast   529 VGFKNDDNHENNDNGTFSV----KKNDNLEKLDSVTNNRKNPAN---FACDVCGKKFTRPYNLKS 586

  Fly   238 HQVMHTGDRKFQCRYCDRTYVNYSGRLRHERTHTNDRPFICAQCGKSFTNSYILKNHMLIHTGER 302
            |.                            |||||:|||||:.|||:|...:..|.|..:|||::
Yeast   587 HL----------------------------RTHTNERPFICSICGKAFARQHDRKRHEDLHTGKK 623

  Fly   303 LFRC--EL-------CHRSFARPTHLKTHFRSNT 327
            .:.|  :|       |.:.|||...|..||::.:
Yeast   624 RYVCGGKLKDGKPWGCGKKFARSDALGRHFKTES 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8159	NP_649823.2	zf-AD	5..78	CDD:214871	14/63 (22%)
		C2H2 Zn finger	194..214	CDD:275368	2/19 (11%)
		COG5048	<197..322	CDD:227381	35/133 (26%)
		zf-H2C2_2	206..231	CDD:290200	5/24 (21%)
		C2H2 Zn finger	222..242	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	1/19 (5%)
		zf-H2C2_2	265..287	CDD:290200	14/21 (67%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		zf-H2C2_2	291..315	CDD:290200	9/32 (28%)
		C2H2 Zn finger	306..328	CDD:275368	9/31 (29%)
CRZ1	NP_014371.1	COG5048	139..617	CDD:227381	70/317 (22%)
		C2H2 Zn finger	571..591	CDD:275368	7/47 (15%)
		C2H2 Zn finger	599..619	CDD:275368	7/19 (37%)
		C2H2 Zn finger	627..655	CDD:275368	9/27 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100