DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8159 and ZNF341

DIOPT Version :9

Sequence 1:	NP_649823.2	Gene:	CG8159 / 41040	FlyBaseID:	FBgn0037619	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_001269862.1	Gene:	ZNF341 / 84905	HGNCID:	15992	Length:	854	Species:	Homo sapiens

Alignment Length:	240	Identity:	61/240 - (25%)
Similarity:	92/240 - (38%)	Gaps:	55/240 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 KRTRRRGLKKGGKGENRTKVTLPVFFCDQCGNNITGKSSFDRHLRKHSGIRPFQCELCPARFLSS 232
            :|..||.|...|.|..        |.|..|......:.....|...|||.:|::|.:|.:.|...
Human   578 ERYLRRHLPTHGSGGR--------FKCQVCKKFFRREHYLKLHAHIHSGEKPYKCSVCESAFNRK 634

  Fly   233 GELKGHQVMHTGDRKFQCRYCDRTYVNYSGRLRHERTHTNDRPFICAQCGKSFTNSYILKNHMLI 297
            .:||.|.::|...:|::|.:               .|||.        |.|.|.....||.|:|.
Human   635 DKLKRHMLIHEPFKKYKCPF---------------STHTG--------CSKEFNRPDKLKAHILS 676

  Fly   298 HTGERLFRCELCHRSFARPTHLKTHFRSNTHKHNLEKSMADAG----------GVQLSPSQSADQ 352
            |:|.:|.:|.||.:||:|..||..|.|::|..:....:....|          ..:|.|.:..|
Human   677 HSGMKLHKCALCSKSFSRRAHLAEHQRAHTGNYKFRCAGCAKGFSRHKYLKDHRCRLGPQKDKD- 740

  Fly   353 VKFVTEKEPEAEA-------DAFTIEVPLP----AEQEQDESLGL 386
              ..|.:.|:..|       ....:..|||    .|:.:|...||
Human   741 --LQTRRPPQRRAAPRSCGSGGRKVLTPLPDPLGLEELKDTGAGL 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8159	NP_649823.2	zf-AD	5..78	CDD:214871
		C2H2 Zn finger	194..214	CDD:275368	3/19 (16%)
		COG5048	<197..322	CDD:227381	36/124 (29%)
		zf-H2C2_2	206..231	CDD:290200	8/24 (33%)
		C2H2 Zn finger	222..242	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	1/19 (5%)
		zf-H2C2_2	265..287	CDD:290200	6/21 (29%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		zf-H2C2_2	291..315	CDD:290200	12/23 (52%)
		C2H2 Zn finger	306..328	CDD:275368	10/21 (48%)
ZNF341	NP_001269862.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	152..217
		COG5048	323..729	CDD:227381	48/181 (27%)
		C2H2 Zn finger	324..344	CDD:275368
		C2H2 Zn finger	352..372	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..434
		C2H2 Zn finger	447..467	CDD:275368
		C2H2 Zn finger	475..497	CDD:275368
		C2H2 Zn finger	505..525	CDD:275368
		C2H2 Zn finger	542..562	CDD:275370
		C2H2 Zn finger	568..588	CDD:275368	4/9 (44%)
		C2H2 Zn finger	596..616	CDD:275368	3/19 (16%)
		C2H2 Zn finger	624..644	CDD:275368	6/19 (32%)
		C2H2 Zn finger	652..677	CDD:275368	11/47 (23%)
		C2H2 Zn finger	685..705	CDD:275368	10/19 (53%)
		C2H2 Zn finger	713..730	CDD:275368	1/16 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	731..763		6/34 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146335
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930