DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8159 and CG14710

DIOPT Version :9

Sequence 1:	NP_649823.2	Gene:	CG8159 / 41040	FlyBaseID:	FBgn0037619	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_650092.4	Gene:	CG14710 / 41393	FlyBaseID:	FBgn0037920	Length:	415	Species:	Drosophila melanogaster

Alignment Length:	407	Identity:	113/407 - (27%)
Similarity:	187/407 - (45%)	Gaps:	86/407 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CRVCASSTDNSKSLKLF-NSGACKVLQQINLLTGVLLQCEPGLPDWMCETCQTDLKSAISFRDRC 69
            ||:|....:.|:.:.|| :.|...:.:::.|...:.::..|.||:..|.:|...::...:||..|
  Fly    10 CRICLGDFEESQMICLFGDKGESDLRKKLELCCRIRVRQSPQLPEKACNSCCEFVQMWFNFRQMC 74

  Fly    70 LRSQKIFE-------ESLVR---------------------NEEDTFRSSVRRSARSQRQR---- 102
            |.||..:|       |:|.:                     |:|....:::......|..:
  Fly    75 LNSQVYWETSSSERPEALAQASDAEYMLYLYENLHLKLGTENQEKEEITAIEEGDEQQEDQSQEV 139

  Fly   103 ------------HEDTAPKTPASPLEVMI----------KLESLSNGDEEDDGIDHLDSCNE--- 142
                        .||..|.| .||.:::|          ::|.|.  |::.:.::.|.:.|.
  Fly   140 LDFNGFIINESIEEDEEPNT-ESPEQILISHMDSYVDDQQMEELI--DDKGELVEELSNANTFYE 201

  Fly   143 ---ADMELAIKAMSS-------STEDDG----TTSPVRLKR----TRRRGLKKGGKGENRTKVTL 189
               .|.||.:.:..|       ..:..|    ..:.::.||    .:.||.:...|.|.:
  Fly   202 VEYGDEELLMSSAPSPHPSFKMDKQKPGRPRKPDAELKFKRKDINAKERGNQPKCKEEEK----- 261

  Fly   190 PVFFCDQCGNNITGKSSFDRHLRKHSGIRPFQCELCPARFLSSGELKGHQVMHTGDRKFQCRYCD 254
              |.|..|||....||.|..|:..||..:|.|||:|...|...|||:.|...|||||.::|.|||
  Fly   262 --FMCILCGNVFYKKSVFTAHMMTHSEYKPHQCEICNKSFRQMGELRAHIRRHTGDRPYKCMYCD 324

  Fly   255 RTYVNYSGRLRHERTHTNDRPFICAQCGKSFTNSYILKNHMLIHTGERLFRCELCHRSFARPTHL 319
            |.:.:.|.|:||||.|||.||:.|.:|||:||::.|||||:|.|:.::.:.|.:|.:||.....|
  Fly   325 RHFYDRSERVRHERVHTNTRPYACQECGKTFTHTAILKNHILSHSAQKNYNCGICCKSFTLLHQL 389

  Fly   320 KTHFRSNTHKHNLEKSM 336
            |.|.::.||::.:|:::
  Fly   390 KAHLQTLTHRNKMEQTI 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8159	NP_649823.2	zf-AD	5..78	CDD:214871	20/79 (25%)
		C2H2 Zn finger	194..214	CDD:275368	8/19 (42%)
		COG5048	<197..322	CDD:227381	59/124 (48%)
		zf-H2C2_2	206..231	CDD:290200	10/24 (42%)
		C2H2 Zn finger	222..242	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	11/19 (58%)
		zf-H2C2_2	265..287	CDD:290200	14/21 (67%)
		C2H2 Zn finger	278..298	CDD:275368	12/19 (63%)
		zf-H2C2_2	291..315	CDD:290200	10/23 (43%)
		C2H2 Zn finger	306..328	CDD:275368	7/21 (33%)
CG14710	NP_650092.4	zf-AD	9..83	CDD:285071	19/72 (26%)
		COG5048	<261..395	CDD:227381	62/140 (44%)
		C2H2 Zn finger	264..284	CDD:275368	8/19 (42%)
		zf-C2H2	290..312	CDD:278523	9/21 (43%)
		C2H2 Zn finger	292..312	CDD:275368	8/19 (42%)
		zf-H2C2_2	304..327	CDD:290200	13/22 (59%)
		C2H2 Zn finger	320..340	CDD:275368	11/19 (58%)
		zf-H2C2_2	335..357	CDD:290200	14/21 (67%)
		C2H2 Zn finger	348..368	CDD:275368	12/19 (63%)
		C2H2 Zn finger	376..395	CDD:275368	7/18 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I2531
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.960